Trait
Bone marrow failure
Clinical name: Bone marrow hypocellularity
A reduced number of hematopoietic cells present in the bone marrow relative to marrow fat.
Summary
- Also called
- Bone marrow hypoplasia, Hypoplastic bone marrow, Myeloid hypoplasia
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Bone marrow failure, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test75 genes linked to Bone marrow failure
Changes in these genes cause rare conditions in which Bone marrow failure is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AK2adenylate kinase 2 | Always | In 1 condition |
| COPZ1coat protein complex I subunit zeta 1 | Always | In 1 condition |
| DCLRE1BDNA cross-link repair 1B | Always | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Always | In 1 condition |
| ERCC6L2ERCC excision repair 6 like 2 | Always | In 1 condition |
| EXOC3L2exocyst complex component 3 like 2 | Always | In 1 condition |
| FANCCFA complementation group C | Always | In 1 condition |
| FANCFFA complementation group F | Always | In 1 condition |
| FANCIFA complementation group I | Always | In 1 condition |
| FLT3LGfms related receptor tyrosine kinase 3 ligand | Always | In 1 condition |
| MAD2L2mitotic arrest deficient 2 like 2 | Always | In 1 condition |
| MDM4MDM4 regulator of p53 | Always | In 1 condition |
| NHEJ1non-homologous end joining factor 1 | Always | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Always | In 3 conditions |
| PARNpoly(A)-specific ribonuclease | Always | In 3 conditions |
| PDCD1programmed cell death 1 | Always | In 1 condition |
| RPL17ribosomal protein L17 | Always | In 1 condition |
| RPL26ribosomal protein L26 | Always | In 1 condition |
| SLC30A7solute carrier family 30 member 7 | Always | In 1 condition |
| STN1STN1 subunit of CST complex | Always | In 1 condition |
| TBXAS1thromboxane A synthase 1 | Always | In 1 condition |
| THPOthrombopoietin | Always | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Always | In 6 conditions |
| WASWASP actin nucleation promoting factor | Always | In 1 condition |
| WRAP53WD repeat containing antisense to TP53 | Always | In 2 conditions |
| DNAJC21DnaJ heat shock protein family (Hsp40) member C21 | Very often (80–99%) | In 2 conditions |
| FANCD2FA complementation group D2 | Very often (80–99%) | In 1 condition |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Very often (80–99%) | In 1 condition |
| GATA2GATA binding protein 2 | Very often (80–99%) | In 1 condition |
| IFNGinterferon gamma | Very often (80–99%) | In 2 conditions |
| MYSM1Myb like, SWIRM and MPN domains 1 | Very often (80–99%) | In 2 conditions |
| PRF1perforin 1 | Very often (80–99%) | In 2 conditions |
| SBDSSBDS ribosome maturation factor | Very often (80–99%) | In 3 conditions |
| TERCtelomerase RNA component | Very often (80–99%) | In 5 conditions |
| TERTtelomerase reverse transcriptase | Very often (80–99%) | In 7 conditions |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Often (30–79%) | In 3 conditions |
| CLPBClpB family mitochondrial disaggregase | Often (30–79%) | In 1 condition |
| CTC1CST telomere replication complex component 1 | Often (30–79%) | In 2 conditions |
| DKC1dyskerin pseudouridine synthase 1 | Often (30–79%) | In 4 conditions |
| GATA1GATA binding protein 1 | Often (30–79%) | In 1 condition |
Show 35 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NOP10NOP10 ribonucleoprotein | Often (30–79%) | In 2 conditions |
| NPM1nucleophosmin 1 | Often (30–79%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Often (30–79%) | In 3 conditions |
| SRP72signal recognition particle 72 | Often (30–79%) | In 1 condition |
| TLR8toll like receptor 8 | Often (30–79%) | In 1 condition |
| TYMSthymidylate synthetase | Often (30–79%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Often (30–79%) | In 2 conditions |
| WDR19WD repeat domain 19 | Often (30–79%) | In 1 condition |
| ADA2adenosine deaminase 2 | Sometimes (5–29%) | In 1 condition |
| CA2carbonic anhydrase 2 | Sometimes (5–29%) | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Sometimes (5–29%) | In 1 condition |
| EFL1elongation factor like GTPase 1 | Sometimes (5–29%) | In 1 condition |
| FANCLFA complementation group L | Sometimes (5–29%) | In 1 condition |
| PGM3phosphoglucomutase 3 | Sometimes (5–29%) | In 1 condition |
| RPA1replication protein A1 | Sometimes (5–29%) | In 1 condition |
| RPS14ribosomal protein S14 | Sometimes (5–29%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Sometimes (5–29%) | In 2 conditions |
| CASP10caspase 10 | Rarely (1–4%) | In 1 condition |
| FASFas cell surface death receptor | Rarely (1–4%) | In 1 condition |
| FASLGFas ligand | Rarely (1–4%) | In 1 condition |
| GNASGNAS complex locus | Rarely (1–4%) | In 1 condition |
| SF3B1splicing factor 3b subunit 1 | Rarely (1–4%) | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Rarely (1–4%) | In 1 condition |
| ADH5alcohol dehydrogenase 5 (class III), chi polypeptide | Not recorded | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Not recorded | In 1 condition |
| BRIP1BRCA1 interacting DNA helicase 1 | Not recorded | In 1 condition |
| DDX41DEAD-box helicase 41 | Not recorded | In 1 condition |
| IVDisovaleryl-CoA dehydrogenase | Not recorded | In 1 condition |
| LBRlamin B receptor | Not recorded | In 1 condition |
| NBNnibrin | Not recorded | In 1 condition |
| SAMD9sterile alpha motif domain containing 9 | Not recorded | In 1 condition |
| TGFB1transforming growth factor beta 1 | Not recorded | In 1 condition |
| UBE2Tubiquitin conjugating enzyme E2 T | Not recorded | In 1 condition |
| ZCCHC8zinc finger CCHC-type containing 8 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks