Trait
Increased circulating IgM concentration
An abnormally increased level of immunoglobulin M in blood.
Summary
- Also called
- Increased IgM levels, Increased levels of IgM
Reference genomeGRCh38hg38
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Get my Genome Test35 genes linked to Increased circulating IgM concentration
Changes in these genes cause rare conditions in which Increased circulating IgM concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CD247CD247 molecule | Always | In 1 condition |
| CD40LGCD40 ligand | Always | In 1 condition |
| DMRT2doublesex and mab-3 related transcription factor 2 | Always | In 1 condition |
| NHEJ1non-homologous end joining factor 1 | Always | In 1 condition |
| NSMCE3NSE3 component of SMC5/6 complex | Always | In 1 condition |
| OTULINOTU deubiquitinase with linear linkage specificity | Always | In 1 condition |
| RASGRP1RAS guanyl releasing protein 1 | Always | In 1 condition |
| UNGuracil DNA glycosylase | Always | In 1 condition |
| AICDAactivation induced cytidine deaminase | Very often (80–99%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Very often (80–99%) | In 1 condition |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Very often (80–99%) | In 2 conditions |
| COPZ1coat protein complex I subunit zeta 1 | Often (30–79%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Often (30–79%) | In 2 conditions |
| IL12Ainterleukin 12A | Often (30–79%) | In 1 condition |
| IL12RB1interleukin 12 receptor subunit beta 1 | Often (30–79%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 1 condition |
| MMEL1membrane metalloendopeptidase like 1 | Often (30–79%) | In 1 condition |
| PGM3phosphoglucomutase 3 | Often (30–79%) | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Often (30–79%) | In 1 condition |
| POU2AF1POU class 2 homeobox associating factor 1 | Often (30–79%) | In 1 condition |
| SPIBSpi-B transcription factor | Often (30–79%) | In 1 condition |
| SPPL2Asignal peptide peptidase like 2A | Often (30–79%) | In 1 condition |
| TNFSF15TNF superfamily member 15 | Often (30–79%) | In 1 condition |
| TNPO3transportin 3 | Often (30–79%) | In 1 condition |
| TPP2tripeptidyl peptidase 2 | Often (30–79%) | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Often (30–79%) | In 1 condition |
| NFKBIANFKB inhibitor alpha | Sometimes (5–29%) | In 1 condition |
| CASP10caspase 10 | Not recorded | In 1 condition |
| CD40CD40 molecule | Not recorded | In 1 condition |
| DNMT3BDNA methyltransferase 3 beta | Not recorded | In 1 condition |
| FASFas cell surface death receptor | Not recorded | In 1 condition |
| FASLGFas ligand | Not recorded | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Not recorded | In 1 condition |
| SH2D1ASH2 domain containing 1A | Not recorded | In 1 condition |
| XIAPX-linked inhibitor of apoptosis | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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