Trait
Colitis
Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the large intestine (colon, cecum and rectum). Colitides may be acute and self-limited or chronic, and broadly fit into the category of digestive diseases.
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test36 genes linked to Colitis
Changes in these genes cause rare conditions in which Colitis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BCL10BCL10 immune signaling adaptor | Always | In 1 condition |
| IL10RAinterleukin 10 receptor subunit alpha | Always | In 1 condition |
| ITGAVintegrin subunit alpha V | Always | In 1 condition |
| LYNLYN proto-oncogene, Src family tyrosine kinase | Always | In 1 condition |
| NCF4neutrophil cytosolic factor 4 | Always | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Always | In 1 condition |
| PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Always | In 1 condition |
| PSTPIP1proline-serine-threonine phosphatase interacting protein 1 | Always | In 1 condition |
| SKIC2SKI2 subunit of superkiller complex | Always | In 2 conditions |
| STXBP2syntaxin binding protein 2 | Always | In 2 conditions |
| ELF4E74 like ETS transcription factor 4 | Often (30–79%) | In 1 condition |
| FERMT1FERM domain containing kindlin 1 | Often (30–79%) | In 1 condition |
| POLA1DNA polymerase alpha 1, catalytic subunit | Often (30–79%) | In 1 condition |
| SHARPINSHANK associated RH domain interactor | Often (30–79%) | In 1 condition |
| SYKspleen associated tyrosine kinase | Often (30–79%) | In 1 condition |
| ZAP70zeta chain of T cell receptor associated protein kinase 70 | Often (30–79%) | In 2 conditions |
| CARMIL2capping protein regulator and myosin 1 linker 2 | Sometimes (5–29%) | In 1 condition |
| FCHO1FCH and mu domain containing endocytic adaptor 1 | Sometimes (5–29%) | In 1 condition |
| GPIHBP1glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 | Sometimes (5–29%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Sometimes (5–29%) | In 1 condition |
| LRBALPS responsive beige-like anchor protein | Sometimes (5–29%) | In 1 condition |
| PRF1perforin 1 | Sometimes (5–29%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Sometimes (5–29%) | In 1 condition |
| SKIC3SKI3 subunit of superkiller complex | Sometimes (5–29%) | In 1 condition |
| STX11syntaxin 11 | Sometimes (5–29%) | In 1 condition |
| TNFAIP3TNF alpha induced protein 3 | Sometimes (5–29%) | In 1 condition |
| UNC13Dunc-13 homolog D | Sometimes (5–29%) | In 1 condition |
| XIAPX-linked inhibitor of apoptosis | Sometimes (5–29%) | In 2 conditions |
| CASP10caspase 10 | Rarely (1–4%) | In 1 condition |
| FASFas cell surface death receptor | Rarely (1–4%) | In 1 condition |
| FASLGFas ligand | Rarely (1–4%) | In 1 condition |
| FOXP3forkhead box P3 | Rarely (1–4%) | In 1 condition |
| BACH2BACH transcriptional regulator 2 | Not recorded | In 1 condition |
| CIITAclass II major histocompatibility complex transactivator | Not recorded | In 1 condition |
| HPS1HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 | Not recorded | In 1 condition |
| IVNS1ABPinfluenza virus NS1A binding protein | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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