Trait
Hydrops fetalis
The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema.
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test71 genes linked to Hydrops fetalis
Changes in these genes cause rare conditions in which Hydrops fetalis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ESAMendothelial cell adhesion molecule | Always | In 1 condition |
| HYAL2hyaluronidase 2 | Always | In 1 condition |
| NEXNnexilin F-actin binding protein | Always | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Always | In 2 conditions |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Always | In 1 condition |
| SNAPINSNAP associated protein | Always | In 1 condition |
| HBA1hemoglobin subunit alpha 1 | Very often (80–99%) | In 1 condition |
| HBA2hemoglobin subunit alpha 2 | Very often (80–99%) | In 1 condition |
| LBRlamin B receptor | Very often (80–99%) | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Very often (80–99%) | In 2 conditions |
| TRIP11thyroid hormone receptor interactor 11 | Very often (80–99%) | In 2 conditions |
| AHCYadenosylhomocysteinase | Often (30–79%) | In 1 condition |
| ALG8ALG8 alpha-1,3-glucosyltransferase | Often (30–79%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Often (30–79%) | In 2 conditions |
| DYNC2H1dynein cytoplasmic 2 heavy chain 1 | Often (30–79%) | In 1 condition |
| DYNC2I1dynein 2 intermediate chain 1 | Often (30–79%) | In 1 condition |
| DYNC2I2dynein 2 intermediate chain 2 | Often (30–79%) | In 1 condition |
| FLNBfilamin B | Often (30–79%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Often (30–79%) | In 1 condition |
| GUSBglucuronidase beta | Often (30–79%) | In 2 conditions |
| IFT80intraflagellar transport 80 | Often (30–79%) | In 1 condition |
| KIF20Akinesin family member 20A | Often (30–79%) | In 1 condition |
| LYNLYN proto-oncogene, Src family tyrosine kinase | Often (30–79%) | In 1 condition |
| MECOMMDS1 and EVI1 complex locus | Often (30–79%) | In 1 condition |
| NSFN-ethylmaleimide sensitive factor, vesicle fusing ATPase | Often (30–79%) | In 1 condition |
| PKLRpyruvate kinase L/R | Often (30–79%) | In 1 condition |
| TALDO1transaldolase 1 | Often (30–79%) | In 1 condition |
| WDR35WD repeat domain 35 | Often (30–79%) | In 3 conditions |
| ABCC6ATP binding cassette subfamily C member 6 | Sometimes (5–29%) | In 1 condition |
| ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 | Sometimes (5–29%) | In 1 condition |
| AGGF1angiogenic factor with G-patch and FHA domains 1 | Sometimes (5–29%) | In 1 condition |
| ALG9ALG9 alpha-1,2-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| CCBE1collagen and calcium binding EGF domains 1 | Sometimes (5–29%) | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Sometimes (5–29%) | In 1 condition |
| FAT4FAT atypical cadherin 4 | Sometimes (5–29%) | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Sometimes (5–29%) | In 2 conditions |
| GLB1galactosidase beta 1 | Sometimes (5–29%) | In 2 conditions |
| GPIglucose-6-phosphate isomerase | Sometimes (5–29%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Sometimes (5–29%) | In 1 condition |
| KIAA0586KIAA0586 | Sometimes (5–29%) | In 1 condition |
Show 31 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| KLF1KLF transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| MGAT2alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | Sometimes (5–29%) | In 1 condition |
| MMACHCmetabolism of cobalamin associated C | Sometimes (5–29%) | In 1 condition |
| NEK9NIMA related kinase 9 | Sometimes (5–29%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| SOX18SRY-box transcription factor 18 | Sometimes (5–29%) | In 1 condition |
| TAFAZZINtafazzin, phospholipid-lysophospholipid transacylase | Sometimes (5–29%) | In 1 condition |
| VAC14VAC14 component of PIKFYVE complex | Sometimes (5–29%) | In 1 condition |
| WNT7AWnt family member 7A | Sometimes (5–29%) | In 1 condition |
| ASAH1N-acylsphingosine amidohydrolase 1 | Rarely (1–4%) | In 1 condition |
| CASP10caspase 10 | Rarely (1–4%) | In 1 condition |
| EPB41erythrocyte membrane protein band 4.1 | Rarely (1–4%) | In 1 condition |
| FASFas cell surface death receptor | Rarely (1–4%) | In 1 condition |
| FASLGFas ligand | Rarely (1–4%) | In 1 condition |
| GYPCglycophorin C (Gerbich blood group) | Rarely (1–4%) | In 1 condition |
| SPTA1spectrin alpha, erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| SPTBspectrin beta, erythrocytic | Rarely (1–4%) | In 1 condition |
| TRIM37tripartite motif containing 37 | Rarely (1–4%) | In 1 condition |
| BSNDbarttin CLCNK type accessory subunit beta | Not recorded | In 1 condition |
| CDAN1codanin 1 | Not recorded | In 1 condition |
| COL11A1collagen type XI alpha 1 chain | Not recorded | In 1 condition |
| GBE11,4-alpha-glucan branching enzyme 1 | Not recorded | In 1 condition |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Not recorded | In 1 condition |
| NEK1NIMA related kinase 1 | Not recorded | In 1 condition |
| NEU1neuraminidase 1 | Not recorded | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Not recorded | In 1 condition |
| PLD1phospholipase D1 | Not recorded | In 1 condition |
| RHDRh blood group D antigen | Not recorded | In 1 condition |
| RYR1ryanodine receptor 1 | Not recorded | In 1 condition |
| SLC17A5solute carrier family 17 member 5 | Not recorded | In 1 condition |
| TAPT1transmembrane anterior posterior transformation 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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