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Gene

CASP10

caspase 10

Summary

Cytogenetic location
2q33.1
Coordinates
Chromosome 2: 201,183,141–201,221,665 (GRCh38)
Exons
10 exons across 38.5 kb
Protein
522 amino acids
Also known as
MCH4, FLICE-2
MANE Select transcript
ENST00000286186.11NM_032977.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Autoimmune Disease

    • A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis).

      • 1 GenCC submitter rates it definitive or strong

  • Autoimmune Lymphoproliferative Syndrome (ALPS)

    • Autoimmune lymphoproliferative syndrome

      Chronic lymph node and spleen enlargement, autoimmune cytopenias and raised double-negative T cells caused by changes in FAS, FASLG, CASP10 and related apoptosis genes.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Diagnosis allows sirolimus or other immunosuppression for cytopenias, avoidance of unnecessary splenectomy, lymphoma vigilance and family testing.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • 1 GenCC submitter rates it definitive or strong

How CASP10 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where CASP10 sits. CASP10 and 16 genes near it on chromosome 2, from 200,702,403 to 201,702,402.Chromosome 22q33.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3200.8 Mb201 Mb201.2 Mb201.4 Mb201.6 MbBZW1: 200,810,594–200,827,921, forward strandBZW1CLK1: 200,853,009–200,864,728, reverse strandCLK1PPIL3: 200,870,907–200,889,358, reverse strandPPIL3NIF3L1: 200,888,992–200,905,579, forward strandNIF3L1ORC2: 200,908,684–200,963,704, reverse strandORC2HYCC2: 200,966,317–201,071,700, reverse strandHYCC2NDUFB3: 201,071,433–201,085,757, forward strandNDUFB3CFLAR: 201,116,005–201,176,687, forward strandCFLARCASP10: 201,183,141–201,221,665, forward strandCASP10CASP8: 201,233,443–201,361,836, forward strandCASP8FLACC1: 201,287,397–201,357,398, reverse strandFLACC1TRAK2: 201,377,207–201,453,449, reverse strandTRAK2STRADB: 201,387,858–201,502,687, forward strandSTRADBCATSPERT: 201,487,421–201,619,179, reverse strandCATSPERTTMEM237: 201,620,184–201,643,570, reverse strandTMEM237MPP4: 201,644,870–201,698,713, reverse strandMPP4ALS2: 201,700,267–201,782,112, reverse strandALS2Diagram of CASP10: 10 exons on the forward strand of chromosome 2Exon 10: 1 known disease-causing siteExon 1: 201,183,141–201,183,308, 168 basesExon 2: 201,185,771–201,186,124, 354 basesExon 3: 201,187,706–201,187,799, 94 basesExon 4: 201,192,984–201,193,119, 136 basesExon 5: 201,195,842–201,195,948, 107 basesExon 6: 201,203,730–201,203,766, 37 basesExon 7: 201,205,882–201,205,973, 92 basesExon 8: 201,208,075–201,208,183, 109 basesExon 9: 201,209,070–201,209,562, 493 basesExon 10: 201,217,588–201,221,665, 4,078 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.7 kb of the gene's 38.5 kb; 1,569 of those bases code for the protein.

How a genome test reads CASP10

1

position in CASP10 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 38.5 kb of CASP10, introns included, not only the 5.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CASP10 gene: caspase 10. Retrieved 16 October 2026, from https://dantelabs.com/genes/casp10

Vancouver

Dante Labs. CASP10 gene: caspase 10 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/casp10

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