Trait
Increased circulating IgG concentration
An abnormally increased level of immunoglobulin G in blood.
Summary
- Also called
- Increased circulating IgG level, Increased IgG level, Increased levels of IgG, Increased total IgG in blood
Reference genomeGRCh38hg38
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Get my Genome Test29 genes linked to Increased circulating IgG concentration
Changes in these genes cause rare conditions in which Increased circulating IgG concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CARD10caspase recruitment domain family member 10 | Always | In 1 condition |
| CD247CD247 molecule | Always | In 1 condition |
| DMRT2doublesex and mab-3 related transcription factor 2 | Always | In 1 condition |
| IL2RBinterleukin 2 receptor subunit beta | Always | In 1 condition |
| IPO8importin 8 | Always | In 1 condition |
| PDCD1programmed cell death 1 | Always | In 1 condition |
| POMPproteasome maturation protein | Always | In 1 condition |
| PSMB8proteasome 20S subunit beta 8 | Always | In 1 condition |
| RASGRP1RAS guanyl releasing protein 1 | Always | In 1 condition |
| STING1stimulator of interferon response cGAMP interactor 1 | Always | In 1 condition |
| TPP2tripeptidyl peptidase 2 | Always | In 1 condition |
| CASP10caspase 10 | Often (30–79%) | In 2 conditions |
| CCND1cyclin D1 | Often (30–79%) | In 1 condition |
| COPZ1coat protein complex I subunit zeta 1 | Often (30–79%) | In 1 condition |
| DOCK8dedicator of cytokinesis 8 | Often (30–79%) | In 1 condition |
| FASFas cell surface death receptor | Often (30–79%) | In 2 conditions |
| FASLGFas ligand | Often (30–79%) | In 2 conditions |
| ITGAVintegrin subunit alpha V | Often (30–79%) | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Often (30–79%) | In 1 condition |
| NCKAP1LNCK associated protein 1 like | Often (30–79%) | In 1 condition |
| NLRP1NLR family pyrin domain containing 1 | Often (30–79%) | In 1 condition |
| PGM3phosphoglucomutase 3 | Often (30–79%) | In 2 conditions |
| TGFB1transforming growth factor beta 1 | Often (30–79%) | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Often (30–79%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Sometimes (5–29%) | In 1 condition |
| IL7Rinterleukin 7 receptor | Sometimes (5–29%) | In 1 condition |
| NFKBIANFKB inhibitor alpha | Sometimes (5–29%) | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Rarely (1–4%) | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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