Trait
Arthritis
Inflammation of a joint.
Summary
- Also called
- Joint inflammation
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Arthritis, and the rest of your genome, with one test.
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Get my Genome Test173 genes linked to Arthritis
Changes in these genes cause rare conditions in which Arthritis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ELF4E74 like ETS transcription factor 4 | Always | In 1 condition |
| IKZF2IKAROS family zinc finger 2 | Always | In 1 condition |
| LYNLYN proto-oncogene, Src family tyrosine kinase | Always | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Always | In 5 conditions |
| PDCD1programmed cell death 1 | Always | In 2 conditions |
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| PSTPIP1proline-serine-threonine phosphatase interacting protein 1 | Always | In 2 conditions |
| TBK1TANK binding kinase 1 | Always | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Always | In 1 condition |
| ANKHANKH inorganic pyrophosphate transport regulator | Very often (80–99%) | In 1 condition |
| ANKRD55ankyrin repeat domain 55 | Very often (80–99%) | In 2 conditions |
| ASAH1N-acylsphingosine amidohydrolase 1 | Very often (80–99%) | In 2 conditions |
| ATP7BATPase copper transporting beta | Very often (80–99%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Very often (80–99%) | In 2 conditions |
| CCR1C-C motif chemokine receptor 1 | Very often (80–99%) | In 1 condition |
| CD247CD247 molecule | Very often (80–99%) | In 2 conditions |
| CD4CD4 molecule | Very often (80–99%) | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Very often (80–99%) | In 1 condition |
| COPAcoat protein complex I subunit alpha | Very often (80–99%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Very often (80–99%) | In 1 condition |
| FASFas cell surface death receptor | Very often (80–99%) | In 2 conditions |
| GLAgalactosidase alpha | Very often (80–99%) | In 1 condition |
| HGDhomogentisate 1,2-dioxygenase | Very often (80–99%) | In 2 conditions |
| HLA-Bmajor histocompatibility complex, class I, B | Very often (80–99%) | In 4 conditions |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Very often (80–99%) | In 6 conditions |
| IFNGR1interferon gamma receptor 1 | Very often (80–99%) | In 1 condition |
| IL10interleukin 10 | Very often (80–99%) | In 2 conditions |
| IL12Ainterleukin 12A | Very often (80–99%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Very often (80–99%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Very often (80–99%) | In 1 condition |
| IL2RAinterleukin 2 receptor subunit alpha | Very often (80–99%) | In 2 conditions |
| IL2RBinterleukin 2 receptor subunit beta | Very often (80–99%) | In 2 conditions |
| IL6interleukin 6 | Very often (80–99%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Very often (80–99%) | In 2 conditions |
| KLRC4killer cell lectin like receptor C4 | Very often (80–99%) | In 1 condition |
| LACC1laccase domain multifunctional purine nucleosidase 1 | Very often (80–99%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Very often (80–99%) | In 3 conditions |
| MIFmacrophage migration inhibitory factor | Very often (80–99%) | In 1 condition |
| MMP14matrix metallopeptidase 14 | Very often (80–99%) | In 1 condition |
| MMP2matrix metallopeptidase 2 | Very often (80–99%) | In 1 condition |
Show 133 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NOD2nucleotide binding oligomerization domain containing 2 | Very often (80–99%) | In 3 conditions |
| PTPN2protein tyrosine phosphatase non-receptor type 2 | Very often (80–99%) | In 2 conditions |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Very often (80–99%) | In 5 conditions |
| STAT4signal transducer and activator of transcription 4 | Very often (80–99%) | In 5 conditions |
| TLR4toll like receptor 4 | Very often (80–99%) | In 1 condition |
| TNFRSF11BTNF receptor superfamily member 11b | Very often (80–99%) | In 1 condition |
| UBAC2UBA domain containing 2 | Very often (80–99%) | In 1 condition |
| AP1S3adaptor related protein complex 1 subunit sigma 3 | Often (30–79%) | In 1 condition |
| BANK1B cell scaffold protein with ankyrin repeats 1 | Often (30–79%) | In 1 condition |
| BLKBLK proto-oncogene, Src family tyrosine kinase | Often (30–79%) | In 1 condition |
| BLNKB cell linker | Often (30–79%) | In 1 condition |
| BTKBruton tyrosine kinase | Often (30–79%) | In 1 condition |
| C1QBcomplement C1q B chain | Often (30–79%) | In 1 condition |
| C2orf69chromosome 2 open reading frame 69 | Often (30–79%) | In 1 condition |
| C4Bcomplement C4B (Chido/Rodgers blood group) | Often (30–79%) | In 1 condition |
| CAV1caveolin 1 | Often (30–79%) | In 1 condition |
| CCN2cellular communication network factor 2 | Often (30–79%) | In 1 condition |
| CCR6C-C motif chemokine receptor 6 | Often (30–79%) | In 1 condition |
| CD79ACD79a molecule | Often (30–79%) | In 1 condition |
| CD79BCD79b molecule | Often (30–79%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Often (30–79%) | In 1 condition |
| CR2complement C3d receptor 2 | Often (30–79%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Often (30–79%) | In 3 conditions |
| DNASE1deoxyribonuclease 1 | Often (30–79%) | In 2 conditions |
| DNASE1L3deoxyribonuclease 1L3 | Often (30–79%) | In 1 condition |
| ETS1ETS proto-oncogene 1, transcription factor | Often (30–79%) | In 1 condition |
| FCGR2BFc gamma receptor IIb | Often (30–79%) | In 2 conditions |
| FCGR3BFc gamma receptor IIIb | Often (30–79%) | In 1 condition |
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Often (30–79%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Often (30–79%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Often (30–79%) | In 3 conditions |
| IGHG1immunoglobulin heavy constant gamma 1 (G1m marker) | Often (30–79%) | In 1 condition |
| IGHMimmunoglobulin heavy constant mu | Often (30–79%) | In 1 condition |
| IGLL1immunoglobulin lambda like polypeptide 1 | Often (30–79%) | In 1 condition |
| IL12Binterleukin 12B | Often (30–79%) | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Often (30–79%) | In 1 condition |
| IRAK1interleukin 1 receptor associated kinase 1 | Often (30–79%) | In 2 conditions |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 2 conditions |
| ITGAMintegrin subunit alpha M | Often (30–79%) | In 1 condition |
| JAZF1JAZF zinc finger 1 | Often (30–79%) | In 1 condition |
| KIAA0319LKIAA0319 like | Often (30–79%) | In 1 condition |
| KNSTRNkinetochore localized astrin (SPAG5) binding protein | Often (30–79%) | In 2 conditions |
| LBRlamin B receptor | Often (30–79%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Often (30–79%) | In 1 condition |
| LRRC8Aleucine rich repeat containing 8 VRAC subunit A | Often (30–79%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Often (30–79%) | In 1 condition |
| MLXMAX dimerization protein MLX | Often (30–79%) | In 1 condition |
| MVKmevalonate kinase | Often (30–79%) | In 2 conditions |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Often (30–79%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Often (30–79%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Often (30–79%) | In 3 conditions |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Often (30–79%) | In 1 condition |
| PRKCDprotein kinase C delta | Often (30–79%) | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Often (30–79%) | In 2 conditions |
| PRTN3proteinase 3 | Often (30–79%) | In 1 condition |
| PXKPX domain containing serine/threonine kinase like | Often (30–79%) | In 1 condition |
| SHARPINSHANK associated RH domain interactor | Often (30–79%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Often (30–79%) | In 1 condition |
| SPI1Spi-1 proto-oncogene | Often (30–79%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Often (30–79%) | In 2 conditions |
| TCF3transcription factor 3 | Often (30–79%) | In 1 condition |
| TLR7toll like receptor 7 | Often (30–79%) | In 1 condition |
| TNFAIP3TNF alpha induced protein 3 | Often (30–79%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Often (30–79%) | In 1 condition |
| TNFSF4TNF superfamily member 4 | Often (30–79%) | In 1 condition |
| TNIP1TNFAIP3 interacting protein 1 | Often (30–79%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Often (30–79%) | In 3 conditions |
| UBE2L3ubiquitin conjugating enzyme E2 L3 | Often (30–79%) | In 1 condition |
| ACP5acid phosphatase 5, tartrate resistant | Sometimes (5–29%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Sometimes (5–29%) | In 1 condition |
| AGAaspartylglucosaminidase | Sometimes (5–29%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Sometimes (5–29%) | In 1 condition |
| BMP6bone morphogenetic protein 6 | Sometimes (5–29%) | In 1 condition |
| BTNL2butyrophilin like 2 | Sometimes (5–29%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Sometimes (5–29%) | In 1 condition |
| EPCAMepithelial cell adhesion molecule | Sometimes (5–29%) | In 2 conditions |
| EXT1exostosin glycosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| EXT2exostosin glycosyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| FOXP3forkhead box P3 | Sometimes (5–29%) | In 1 condition |
| GJB2gap junction protein beta 2 | Sometimes (5–29%) | In 1 condition |
| GJB6gap junction protein beta 6 | Sometimes (5–29%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Sometimes (5–29%) | In 1 condition |
| HFEhomeostatic iron regulator | Sometimes (5–29%) | In 1 condition |
| HIRAhistone cell cycle regulator | Sometimes (5–29%) | In 1 condition |
| HNF1BHNF1 homeobox B | Sometimes (5–29%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Sometimes (5–29%) | In 2 conditions |
| IGHG2immunoglobulin heavy constant gamma 2 (G2m marker) | Sometimes (5–29%) | In 1 condition |
| IGKCimmunoglobulin kappa constant | Sometimes (5–29%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Sometimes (5–29%) | In 1 condition |
| LRBALPS responsive beige-like anchor protein | Sometimes (5–29%) | In 1 condition |
| LSM11LSM11, U7 small nuclear RNA associated | Sometimes (5–29%) | In 1 condition |
| PHEXphosphate regulating endopeptidase X-linked | Sometimes (5–29%) | In 1 condition |
| RNASEH2Aribonuclease H2 subunit A | Sometimes (5–29%) | In 1 condition |
| RNASEH2Bribonuclease H2 subunit B | Sometimes (5–29%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Sometimes (5–29%) | In 1 condition |
| RNF168ring finger protein 168 | Sometimes (5–29%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Sometimes (5–29%) | In 1 condition |
| SYKspleen associated tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| TBX1T-box transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| TFtransferrin | Sometimes (5–29%) | In 1 condition |
| THSD4thrombospondin type 1 domain containing 4 | Sometimes (5–29%) | In 1 condition |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Sometimes (5–29%) | In 1 condition |
| VPS13Avacuolar protein sorting 13 homolog A | Sometimes (5–29%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Sometimes (5–29%) | In 1 condition |
| XIAPX-linked inhibitor of apoptosis | Sometimes (5–29%) | In 1 condition |
| CASP10caspase 10 | Rarely (1–4%) | In 1 condition |
| FASLGFas ligand | Rarely (1–4%) | In 1 condition |
| FGF10fibroblast growth factor 10 | Rarely (1–4%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Rarely (1–4%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Rarely (1–4%) | In 1 condition |
| KRT5keratin 5 | Rarely (1–4%) | In 1 condition |
| MYH14myosin heavy chain 14 | Rarely (1–4%) | In 1 condition |
| POFUT1protein O-fucosyltransferase 1 | Rarely (1–4%) | In 1 condition |
| POGLUT1protein O-glucosyltransferase 1 | Rarely (1–4%) | In 1 condition |
| PSENENpresenilin enhancer, gamma-secretase subunit | Rarely (1–4%) | In 1 condition |
| ABCG2ATP binding cassette subfamily G member 2 (JR blood group) | Not recorded | In 1 condition |
| ABCG8ATP binding cassette subfamily G member 8 | Not recorded | In 1 condition |
| ADA2adenosine deaminase 2 | Not recorded | In 1 condition |
| FCGR2AFc gamma receptor IIa | Not recorded | In 1 condition |
| HJVhemojuvelin BMP co-receptor | Not recorded | In 1 condition |
| HLA-Cmajor histocompatibility complex, class I, C | Not recorded | In 1 condition |
| HOXD10homeobox D10 | Not recorded | In 1 condition |
| NLRP12NLR family pyrin domain containing 12 | Not recorded | In 1 condition |
| PRG4proteoglycan 4 | Not recorded | In 1 condition |
| PSMB4proteasome 20S subunit beta 4 | Not recorded | In 1 condition |
| RAG1recombination activating 1 | Not recorded | In 1 condition |
| RAG2recombination activating 2 | Not recorded | In 1 condition |
| TFR2transferrin receptor 2 | Not recorded | In 1 condition |
| UBA1ubiquitin like modifier activating enzyme 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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