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Trait
Decreased circulating IgM concentration
An abnormally decreased level of immunoglobulin M (IgM) in blood.
Summary
- Also called
- Decreased IgM, Decreased IgM level, IgM deficiency, Reduced IgM levels
Decreased circulating IgM concentrationHP:0002850
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Read the genes linked to Decreased circulating IgM concentration, and the rest of your genome, with one test.
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Get my Genome Test85 genes linked to Decreased circulating IgM concentration
Changes in these genes cause rare conditions in which Decreased circulating IgM concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADA2adenosine deaminase 2 | Always | In 1 condition |
| ALG12ALG12 alpha-1,6-mannosyltransferase | Always | In 1 condition |
| BLNKB cell linker | Always | In 1 condition |
| BTKBruton tyrosine kinase | Always | In 1 condition |
| CD79BCD79b molecule | Always | In 1 condition |
| DOCK8dedicator of cytokinesis 8 | Always | In 1 condition |
| EXTL3exostosin like glycosyltransferase 3 | Always | In 2 conditions |
| IGLL1immunoglobulin lambda like polypeptide 1 | Always | In 1 condition |
| IL6Rinterleukin 6 receptor | Always | In 1 condition |
| IRF2BP2interferon regulatory factor 2 binding protein 2 | Always | In 1 condition |
| IRF4interferon regulatory factor 4 | Always | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| LCKLCK proto-oncogene, Src family tyrosine kinase | Always | In 1 condition |
| LIG1DNA ligase 1 | Always | In 1 condition |
| MAP3K14mitogen-activated protein kinase kinase kinase 14 | Always | In 1 condition |
| NBNnibrin | Always | In 1 condition |
| NFKB2nuclear factor kappa B subunit 2 | Always | In 1 condition |
| PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Always | In 1 condition |
| PLCG2phospholipase C gamma 2 | Always | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Always | In 1 condition |
| PTPRCprotein tyrosine phosphatase receptor type C | Always | In 1 condition |
| RAC2Rac family small GTPase 2 | Always | In 1 condition |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| SH3KBP1SH3 domain containing kinase binding protein 1 | Always | In 1 condition |
| SIK3SIK family kinase 3 | Always | In 1 condition |
| SPI1Spi-1 proto-oncogene | Always | In 1 condition |
| TCF3transcription factor 3 | Always | In 1 condition |
| TNFRSF13CTNF receptor superfamily member 13C | Always | In 1 condition |
| TOM1target of myb1 membrane trafficking protein | Always | In 1 condition |
| LRBALPS responsive beige-like anchor protein | Very often (80–99%) | In 1 condition |
| RAG1recombination activating 1 | Very often (80–99%) | In 1 condition |
| RAG2recombination activating 2 | Very often (80–99%) | In 1 condition |
| RFX5regulatory factor X5 | Very often (80–99%) | In 2 conditions |
| SASH3SAM and SH3 domain containing 3 | Very often (80–99%) | In 1 condition |
| TOP2BDNA topoisomerase II beta | Very often (80–99%) | In 1 condition |
| ZBTB24zinc finger and BTB domain containing 24 | Very often (80–99%) | In 1 condition |
| AK2adenylate kinase 2 | Often (30–79%) | In 1 condition |
| ARHGEF1Rho guanine nucleotide exchange factor 1 | Often (30–79%) | In 1 condition |
| ATP6AP1ATPase H+ transporting accessory protein 1 | Often (30–79%) | In 1 condition |
| BACH2BACH transcriptional regulator 2 | Often (30–79%) | In 1 condition |
Show 45 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| BLMBLM RecQ like helicase | Often (30–79%) | In 2 conditions |
| CARD11caspase recruitment domain family member 11 | Often (30–79%) | In 2 conditions |
| CASP8caspase 8 | Often (30–79%) | In 1 condition |
| CBLBCbl proto-oncogene B | Often (30–79%) | In 1 condition |
| CD19CD19 molecule | Often (30–79%) | In 1 condition |
| CD3ECD3 epsilon subunit of T-cell receptor complex | Often (30–79%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Often (30–79%) | In 2 conditions |
| FNIP1folliculin interacting protein 1 | Often (30–79%) | In 1 condition |
| ICOSinducible T cell costimulator | Often (30–79%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Often (30–79%) | In 3 conditions |
| IKZF2IKAROS family zinc finger 2 | Often (30–79%) | In 1 condition |
| IVNS1ABPinfluenza virus NS1A binding protein | Often (30–79%) | In 1 condition |
| KNSTRNkinetochore localized astrin (SPAG5) binding protein | Often (30–79%) | In 1 condition |
| LYNLYN proto-oncogene, Src family tyrosine kinase | Often (30–79%) | In 1 condition |
| MOGSmannosyl-oligosaccharide glucosidase | Often (30–79%) | In 1 condition |
| NHEJ1non-homologous end joining factor 1 | Often (30–79%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Often (30–79%) | In 2 conditions |
| POLD1DNA polymerase delta 1, catalytic subunit | Often (30–79%) | In 1 condition |
| RFXAPregulatory factor X associated protein | Often (30–79%) | In 1 condition |
| SEC61A1SEC61 translocon subunit alpha 1 | Often (30–79%) | In 1 condition |
| STAT2signal transducer and activator of transcription 2 | Often (30–79%) | In 1 condition |
| STIM1stromal interaction molecule 1 | Often (30–79%) | In 1 condition |
| SYKspleen associated tyrosine kinase | Often (30–79%) | In 1 condition |
| TCN2transcobalamin 2 | Often (30–79%) | In 2 conditions |
| TNFRSF11ATNF receptor superfamily member 11a | Often (30–79%) | In 1 condition |
| CASP10caspase 10 | Sometimes (5–29%) | In 1 condition |
| DOCK11dedicator of cytokinesis 11 | Sometimes (5–29%) | In 1 condition |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 1 condition |
| FASLGFas ligand | Sometimes (5–29%) | In 1 condition |
| IGHG2immunoglobulin heavy constant gamma 2 (G2m marker) | Sometimes (5–29%) | In 1 condition |
| IGKCimmunoglobulin kappa constant | Sometimes (5–29%) | In 1 condition |
| IL6STinterleukin 6 cytokine family signal transducer | Sometimes (5–29%) | In 1 condition |
| JAK3Janus kinase 3 | Sometimes (5–29%) | In 1 condition |
| NAE1NEDD8 activating enzyme E1 subunit 1 | Sometimes (5–29%) | In 1 condition |
| NFKBIANFKB inhibitor alpha | Sometimes (5–29%) | In 1 condition |
| ORAI1ORAI calcium release-activated calcium modulator 1 | Sometimes (5–29%) | In 1 condition |
| PIGTphosphatidylinositol glycan anchor biosynthesis class T | Sometimes (5–29%) | In 1 condition |
| PRIM1DNA primase subunit 1 | Sometimes (5–29%) | In 1 condition |
| RNF168ring finger protein 168 | Sometimes (5–29%) | In 1 condition |
| TYMSthymidylate synthetase | Sometimes (5–29%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Sometimes (5–29%) | In 1 condition |
| ADAadenosine deaminase | Not recorded | In 1 condition |
| CNBPCCHC-type zinc finger nucleic acid binding protein | Not recorded | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Not recorded | In 1 condition |
| LAMTOR2late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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