Trait

Increased inflammatory response

A abnormal increase in the inflammatory response to injury or infection.

HPO HP:0012649

Body system: Abnormality of the immune system

Reference genomeGRCh38hg38

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26 genes linked to Increased inflammatory response

Changes in these genes cause rare conditions in which Increased inflammatory response is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
C4Acomplement C4A (Chido/Rodgers blood group)	Often (30–79%)	In 1 condition
CCR1C-C motif chemokine receptor 1	Often (30–79%)	In 1 condition
CTLA4cytotoxic T-lymphocyte associated protein 4	Often (30–79%)	In 1 condition
ERAP1endoplasmic reticulum aminopeptidase 1	Often (30–79%)	In 1 condition
FASFas cell surface death receptor	Often (30–79%)	In 1 condition
HLA-Bmajor histocompatibility complex, class I, B	Often (30–79%)	In 2 conditions
HLA-DPA1major histocompatibility complex, class II, DP alpha 1	Often (30–79%)	In 1 condition
HLA-DPB1major histocompatibility complex, class II, DP beta 1	Often (30–79%)	In 1 condition
IFNGR1interferon gamma receptor 1	Often (30–79%)	In 2 conditions
IL10interleukin 10	Often (30–79%)	In 1 condition
IL12Ainterleukin 12A	Often (30–79%)	In 1 condition
IL12A-AS1IL12A antisense RNA 1	Often (30–79%)	In 1 condition
IL12Binterleukin 12B	Often (30–79%)	In 1 condition
IL23Rinterleukin 23 receptor	Often (30–79%)	In 1 condition
KLRC4killer cell lectin like receptor C4	Often (30–79%)	In 1 condition
MEFVMEFV innate immunity regulator, pyrin	Often (30–79%)	In 1 condition
MLXMAX dimerization protein MLX	Often (30–79%)	In 1 condition
PRTN3proteinase 3	Often (30–79%)	In 1 condition
PTPN22protein tyrosine phosphatase non-receptor type 22	Often (30–79%)	In 1 condition
STAT4signal transducer and activator of transcription 4	Often (30–79%)	In 1 condition
TLR4toll like receptor 4	Often (30–79%)	In 1 condition
UBAC2UBA domain containing 2	Often (30–79%)	In 1 condition
ANKHANKH inorganic pyrophosphate transport regulator	Sometimes (5–29%)	In 1 condition
PSTPIP1proline-serine-threonine phosphatase interacting protein 1	Sometimes (5–29%)	In 1 condition
TNFRSF11BTNF receptor superfamily member 11b	Sometimes (5–29%)	In 1 condition
TRAPPC2trafficking protein particle complex subunit 2	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal inflammatory response

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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