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Gene

FASLG

Fas ligand

Summary

Cytogenetic location
1q24.3
Coordinates
Chromosome 1: 172,659,103–172,666,876 (GRCh38)
Exons
4 exons across 7.8 kb
Protein
281 amino acids
Also known as
APTL, CD95L, FasL, CD178
Previous symbols
APT1LG1, TNFSF6
MANE Select transcript
ENST00000367721.3NM_000639.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Autoimmune Disease

    • A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis).

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

  • Autoimmune Lymphoproliferative Syndrome (ALPS)

    • Autoimmune lymphoproliferative syndrome

      Chronic lymph node and spleen enlargement, autoimmune cytopenias and raised double-negative T cells caused by changes in FAS, FASLG, CASP10 and related apoptosis genes.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Diagnosis allows sirolimus or other immunosuppression for cytopenias, avoidance of unnecessary splenectomy, lymphoma vigilance and family testing.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

How FASLG is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 1, with a bracket where FASLG sits. FASLG and 6 genes near it on chromosome 1, from 172,162,990 to 173,162,989.Chromosome 11q24.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44172.2 Mb172.4 Mb172.6 Mb172.8 Mb173 MbDNM3: 171,817,887–172,418,466, forward strandDNM3PIGC: 172,370,189–172,444,148, reverse strandPIGCC1orf105: 172,420,675–172,469,120, forward strandC1orf105SUCO: 172,532,349–172,613,183, forward strandSUCOFASLG: 172,659,103–172,666,876, forward strandFASLGTNFSF18: 173,039,202–173,050,941, reverse strandTNFSF18TNFSF4: 173,162,645–173,477,583, reverse strandTNFSF4Diagram of FASLG: 4 exons on the forward strand of chromosome 1Exon 1: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 1: 172,659,103–172,659,549, 447 basesExon 2: 172,660,095–172,660,140, 46 basesExon 3: 172,664,334–172,664,390, 57 basesExon 4: 172,665,622–172,666,876, 1,255 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.8 kb of the gene's 7.8 kb; 846 of those bases code for the protein.

How a genome test reads FASLG

5

positions in FASLG where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.8 kb of FASLG, introns included, not only the 1.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FASLG gene: Fas ligand. Retrieved 17 October 2026, from https://dantelabs.com/genes/faslg

Vancouver

Dante Labs. FASLG gene: Fas ligand [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/faslg

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