Trait
Increased circulating IgE concentration
An abnormally increased overall level of immunoglobulin E in blood.
Summary
- Also called
- Elevated immunoglobulin E, Elevated serum IgE, High immunoglobulin E, Increased circulating IgE level
Reference genomeGRCh38hg38
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Get my Genome Test51 genes linked to Increased circulating IgE concentration
Changes in these genes cause rare conditions in which Increased circulating IgE concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADAM17ADAM metallopeptidase domain 17 | Always | In 1 condition |
| CARD9caspase recruitment domain family member 9 | Always | In 1 condition |
| CD247CD247 molecule | Always | In 1 condition |
| CDSNcorneodesmosin | Always | In 2 conditions |
| DCLRE1CDNA cross-link repair 1C | Always | In 2 conditions |
| DSG1desmoglein 1 | Always | In 1 condition |
| EGFRepidermal growth factor receptor | Always | In 1 condition |
| IKZF2IKAROS family zinc finger 2 | Always | In 1 condition |
| IL21interleukin 21 | Always | In 1 condition |
| IL2RAinterleukin 2 receptor subunit alpha | Always | In 1 condition |
| IL6Rinterleukin 6 receptor | Always | In 1 condition |
| IL6STinterleukin 6 cytokine family signal transducer | Always | In 2 conditions |
| IPO8importin 8 | Always | In 1 condition |
| MAN2B2mannosidase alpha class 2B member 2 | Always | In 1 condition |
| PGM3phosphoglucomutase 3 | Always | In 2 conditions |
| POLD3DNA polymerase delta 3, accessory subunit | Always | In 1 condition |
| RAG1recombination activating 1 | Always | In 1 condition |
| RAG2recombination activating 2 | Always | In 1 condition |
| DOCK8dedicator of cytokinesis 8 | Very often (80–99%) | In 2 conditions |
| FOXP3forkhead box P3 | Very often (80–99%) | In 2 conditions |
| GPC3glypican 3 | Very often (80–99%) | In 1 condition |
| GPC4glypican 4 | Very often (80–99%) | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Very often (80–99%) | In 2 conditions |
| STAT3signal transducer and activator of transcription 3 | Very often (80–99%) | In 2 conditions |
| STAT5Bsignal transducer and activator of transcription 5B | Very often (80–99%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Very often (80–99%) | In 2 conditions |
| ZNF341zinc finger protein 341 | Very often (80–99%) | In 1 condition |
| ADAadenosine deaminase | Often (30–79%) | In 2 conditions |
| ARPC5actin related protein 2/3 complex subunit 5 | Often (30–79%) | In 1 condition |
| CARD10caspase recruitment domain family member 10 | Often (30–79%) | In 1 condition |
| CARD11caspase recruitment domain family member 11 | Often (30–79%) | In 1 condition |
| COPZ1coat protein complex I subunit zeta 1 | Often (30–79%) | In 1 condition |
| DOCK11dedicator of cytokinesis 11 | Often (30–79%) | In 1 condition |
| IRAK4interleukin 1 receptor associated kinase 4 | Often (30–79%) | In 1 condition |
| NCKAP1LNCK associated protein 1 like | Often (30–79%) | In 1 condition |
| NSMCE3NSE3 component of SMC5/6 complex | Often (30–79%) | In 1 condition |
| SLC19A1solute carrier family 19 member 1 | Often (30–79%) | In 1 condition |
| TGFB1transforming growth factor beta 1 | Often (30–79%) | In 1 condition |
| CASP10caspase 10 | Sometimes (5–29%) | In 1 condition |
| EXTL3exostosin like glycosyltransferase 3 | Sometimes (5–29%) | In 1 condition |
Show 11 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| FASFas cell surface death receptor | Sometimes (5–29%) | In 1 condition |
| FASLGFas ligand | Sometimes (5–29%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Sometimes (5–29%) | In 1 condition |
| IL7Rinterleukin 7 receptor | Sometimes (5–29%) | In 1 condition |
| KRT74keratin 74 | Sometimes (5–29%) | In 1 condition |
| NFKBIANFKB inhibitor alpha | Sometimes (5–29%) | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Sometimes (5–29%) | In 1 condition |
| COL7A1collagen type VII alpha 1 chain | Rarely (1–4%) | In 1 condition |
| KRT9keratin 9 | Not recorded | In 1 condition |
| STAT6signal transducer and activator of transcription 6 | Not recorded | In 1 condition |
| TYK2tyrosine kinase 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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