Trait

Rheumatoid factor positive

The presence in the serum of an autoantibody directed against the Fc portion of IgG.

Body system: Abnormality of the immune system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/rheumatoid-factor-positive.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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18 genes linked to Rheumatoid factor positive

Changes in these genes cause rare conditions in which Rheumatoid factor positive is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
CASP10caspase 10	Always	In 2 conditions
LYNLYN proto-oncogene, Src family tyrosine kinase	Always	In 1 condition
STING1stimulator of interferon response cGAMP interactor 1	Always	In 1 condition
PGM3phosphoglucomutase 3	Very often (80–99%)	In 2 conditions
C1QBcomplement C1q B chain	Often (30–79%)	In 1 condition
CARD10caspase recruitment domain family member 10	Often (30–79%)	In 1 condition
DOCK11dedicator of cytokinesis 11	Often (30–79%)	In 1 condition
CYBC1cytochrome b-245 chaperone 1	Sometimes (5–29%)	In 1 condition
FASFas cell surface death receptor	Sometimes (5–29%)	In 2 conditions
FASLGFas ligand	Sometimes (5–29%)	In 2 conditions
RIPK1receptor interacting serine/threonine kinase 1	Sometimes (5–29%)	In 1 condition
CCN6cellular communication network factor 6	Not recorded	In 1 condition
CD244CD244 molecule	Not recorded	In 1 condition
CIITAclass II major histocompatibility complex transactivator	Not recorded	In 1 condition
IFNGR1interferon gamma receptor 1	Not recorded	In 1 condition
IL10interleukin 10	Not recorded	In 1 condition
NFKBIL1NFKB inhibitor like 1	Not recorded	In 1 condition
SLC22A4solute carrier family 22 member 4	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Autoimmune antibody positivity

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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