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Gene

PRKCD

protein kinase C delta

Summary

Cytogenetic location
3p21.1
Coordinates
Chromosome 3: 53,161,209–53,192,717 (GRCh38)
Exons
19 exons across 31.5 kb
Protein
676 amino acids
Also known as
PKCδ
MANE Select transcript
ENST00000330452.8NM_006254.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Autoimmune Disease

    • A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis).

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

  • Autoimmune Lymphoproliferative Syndrome (ALPS)

    • Autoimmune lymphoproliferative syndrome

      Chronic lymph node and spleen enlargement, autoimmune cytopenias and raised double-negative T cells caused by changes in FAS, FASLG, CASP10 and related apoptosis genes.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Diagnosis allows sirolimus or other immunosuppression for cytopenias, avoidance of unnecessary splenectomy, lymphoma vigilance and family testing.

  • Systemic Lupus Erythematosus

    • An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Standard SLE: hydroxychloroquine, mycophenolate, belimumab, anifrolumab; Complement-deficient lupus: FFP replacement; Interferonopathy: anifrolumab, JAK inhibitors; All: sun protection, cardiovascular risk management, pregnancy planning

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • 2 GenCC submitters rate it definitive or strong

How PRKCD is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where PRKCD sits. PRKCD and 18 genes near it on chromosome 3, from 52,676,963 to 53,676,962.Chromosome 33p21.1p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2952.8 Mb53 Mb53.2 Mb53.4 Mb53.6 MbPBRM1: 52,544,271–52,685,979, reverse strandGNL3: 52,681,156–52,696,160, forward strandGNL3GLT8D1: 52,691,527–52,706,368, reverse strandGLT8D1SPCS1: 52,704,955–52,711,148, forward strandSPCS1NEK4: 52,708,444–52,770,973, reverse strandNEK4ITIH1: 52,777,559–52,792,068, forward strandITIH3: 52,794,450–52,809,881, forward strandITIH4: 52,812,918–52,831,069, reverse strand: 52,813,282–52,835,729, reverse strandMUSTN1: 52,833,113–52,835,222, reverse strandMUSTN1STIMATE-MUSTN1: 52,833,121–52,897,562, reverse strandSTIMATE-MUSTN1STIMATE: 52,836,219–52,897,621, reverse strandSTIMATESFMBT1: 52,903,345–53,046,750, reverse strandSFMBT1: 52,969,119–53,099,453, reverse strandRFT1: 53,048,135–53,130,661, reverse strandRFT1PRKCD: 53,161,209–53,192,717, forward strandPRKCDTKT: 53,223,040–53,256,055, reverse strandTKTDCP1A: 53,283,429–53,347,683, reverse strandDCP1ACACNA1D: 53,328,963–53,813,733, forward strandCACNA1DDiagram of PRKCD: 19 exons on the forward strand of chromosome 3Exon 4: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 14: 3 known disease-causing sitesExon 16: 1 known disease-causing siteExon 1: 53,161,209–53,161,428, 220 basesExon 2: 53,165,104–53,165,215, 112 basesExon 3: 53,178,404–53,178,537, 134 basesExon 4: 53,179,577–53,179,776, 200 basesExon 5: 53,181,207–53,181,267, 61 basesExon 6: 53,181,444–53,181,606, 163 basesExon 7: 53,181,701–53,181,732, 32 basesExon 8: 53,183,121–53,183,206, 86 basesExon 9: 53,183,452–53,183,581, 130 basesExon 10: 53,184,874–53,184,974, 101 basesExon 11: 53,185,604–53,185,700, 97 basesExon 12: 53,185,927–53,186,027, 101 basesExon 13: 53,186,167–53,186,340, 174 basesExon 14: 53,186,604–53,186,695, 92 basesExon 15: 53,187,340–53,187,402, 63 basesExon 16: 53,188,720–53,188,858, 139 basesExon 17: 53,189,058–53,189,246, 189 basesExon 18: 53,189,873–53,190,001, 129 basesExon 19: 53,192,108–53,192,717, 610 bases151015195′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 31.5 kb; 2,031 of those bases code for the protein.

How a genome test reads PRKCD

15

positions in PRKCD where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 31.5 kb of PRKCD, introns included, not only the 2.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PRKCD gene: protein kinase C delta. Retrieved 16 October 2026, from https://dantelabs.com/genes/prkcd

Vancouver

Dante Labs. PRKCD gene: protein kinase C delta [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/prkcd

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