Trait
Death of body tissue due to lack of blood flow or infection
Clinical name: Gangrene
A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis).
Summary
- Body system
- Constitutional symptom
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Death of body tissue due to lack of blood flow or infection, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test46 genes linked to Death of body tissue due to lack of blood flow or infection
Changes in these genes cause rare conditions in which Death of body tissue due to lack of blood flow or infection is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| HLA-Bmajor histocompatibility complex, class I, B | Often (30–79%) | In 3 conditions |
| IL12Binterleukin 12B | Often (30–79%) | In 1 condition |
| MLXMAX dimerization protein MLX | Often (30–79%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Sometimes (5–29%) | In 1 condition |
| CATcatalase | Sometimes (5–29%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Sometimes (5–29%) | In 1 condition |
| CD28CD28 molecule | Sometimes (5–29%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Sometimes (5–29%) | In 2 conditions |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Sometimes (5–29%) | In 1 condition |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 1 condition |
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Sometimes (5–29%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Sometimes (5–29%) | In 1 condition |
| IL10interleukin 10 | Sometimes (5–29%) | In 1 condition |
| IL12Ainterleukin 12A | Sometimes (5–29%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Sometimes (5–29%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Sometimes (5–29%) | In 1 condition |
| KIF11kinesin family member 11 | Sometimes (5–29%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PROCprotein C, inactivator of coagulation factors Va and VIIIa | Sometimes (5–29%) | In 1 condition |
| PROS1protein S | Sometimes (5–29%) | In 1 condition |
| PRTN3proteinase 3 | Sometimes (5–29%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 2 conditions |
| STAT4signal transducer and activator of transcription 4 | Sometimes (5–29%) | In 1 condition |
| TLR4toll like receptor 4 | Sometimes (5–29%) | In 1 condition |
| TNFRSF1BTNF receptor superfamily member 1B | Sometimes (5–29%) | In 1 condition |
| UBAC2UBA domain containing 2 | Sometimes (5–29%) | In 1 condition |
| ABCC6ATP binding cassette subfamily C member 6 | Rarely (1–4%) | In 1 condition |
| BCORBCL6 corepressor | Rarely (1–4%) | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Rarely (1–4%) | In 1 condition |
| FIP1L1factor interacting with PAPOLA and CPSF1 | Rarely (1–4%) | In 1 condition |
| IRF2BP2interferon regulatory factor 2 binding protein 2 | Rarely (1–4%) | In 1 condition |
| NABP1nucleic acid binding protein 1 | Rarely (1–4%) | In 1 condition |
| NPM1nucleophosmin 1 | Rarely (1–4%) | In 1 condition |
| NUMA1nuclear mitotic apparatus protein 1 | Rarely (1–4%) | In 1 condition |
| PMLPML nuclear body scaffold | Rarely (1–4%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Rarely (1–4%) | In 1 condition |
Show 6 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| RARAretinoic acid receptor alpha | Rarely (1–4%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Rarely (1–4%) | In 1 condition |
| STAT5Bsignal transducer and activator of transcription 5B | Rarely (1–4%) | In 1 condition |
| TBL1XR1TBL1X/Y related 1 | Rarely (1–4%) | In 1 condition |
| ZBTB16zinc finger and BTB domain containing 16 | Rarely (1–4%) | In 1 condition |
| AGXTalanine--glyoxylate aminotransferase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks