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Gene

LIPN

lipase family member N

Summary

Cytogenetic location
10q23.31
Coordinates
Chromosome 10: 88,760,020–88,779,626 (GRCh38)
Exons
10 exons across 19.6 kb
Protein
398 amino acids
Inheritance
Autosomal recessive
Also known as
bA186O14.3
Previous symbols
LIPL4
MANE Select transcript
ENST00000404459.2NM_001102469.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Ichthyoses

    • Autosomal recessive congenital ichthyosisAutosomal recessive

      A group of recessive ichthyoses, including harlequin ichthyosis and lamellar ichthyosis, usually present at birth, often with a collodion membrane.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Early diagnosis guides neonatal care, emollient and keratolytic regimens, and heat-intolerance precautions.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How LIPN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 10, with a bracket where LIPN sits. LIPN and 11 genes near it on chromosome 10, from 88,269,823 to 89,269,822.Chromosome 1010q23.31p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.388.4 Mb88.6 Mb88.8 Mb89 Mb89.2 MbRNLS: 88,273,551–88,584,530, reverse strandRNLSLIPJ: 88,586,753–88,607,880, forward strandLIPJLIPF: 88,664,441–88,678,814, forward strandLIPFLIPK: 88,706,249–88,752,776, forward strandLIPKLIPN: 88,760,020–88,779,626, forward strandLIPNLIPM: 88,802,730–88,820,546, forward strandLIPMANKRD22: 88,819,896–88,851,940, reverse strandANKRD22STAMBPL1: 88,879,363–88,975,153, forward strandSTAMBPL1ACTA2: 88,934,815–88,991,339, reverse strandACTA2FAS: 88,953,813–89,029,605, forward strandFASCH25H: 89,205,629–89,207,317, reverse strandCH25HLIPA: 89,212,830–89,415,367, reverse strandLIPADiagram of LIPN: 10 exons on the forward strand of chromosome 10Exon 4: 1 known disease-causing siteExon 1: 88,760,020–88,760,106, 87 basesExon 2: 88,761,398–88,761,513, 116 basesExon 3: 88,762,188–88,762,305, 118 basesExon 4: 88,764,410–88,764,608, 199 basesExon 5: 88,766,269–88,766,378, 110 basesExon 6: 88,768,792–88,768,928, 137 basesExon 7: 88,770,845–88,770,991, 147 basesExon 8: 88,774,473–88,774,544, 72 basesExon 9: 88,775,092–88,775,163, 72 basesExon 10: 88,778,009–88,779,626, 1,618 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 19.6 kb; 1,197 of those bases code for the protein.

How a genome test reads LIPN

1

position in LIPN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 19.6 kb of LIPN, introns included, not only the 2.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LIPN gene: lipase family member N. Retrieved 16 October 2026, from https://dantelabs.com/genes/lipn

Vancouver

Dante Labs. LIPN gene: lipase family member N [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/lipn

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