Trait
Retinal detachment
Separation of the inner layers of the retina (neural retina) from the pigment epithelium.
Summary
- Also called
- Detached retina
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test110 genes linked to Retinal detachment
Changes in these genes cause rare conditions in which Retinal detachment is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| COL9A2collagen type IX alpha 2 chain | Always | In 2 conditions |
| ESAMendothelial cell adhesion molecule | Always | In 1 condition |
| HYAL2hyaluronidase 2 | Always | In 1 condition |
| LRP5LDL receptor related protein 5 | Always | In 3 conditions |
| NDPnorrin cystine knot growth factor NDP | Always | In 4 conditions |
| NHEJ1non-homologous end joining factor 1 | Always | In 1 condition |
| OTX2orthodenticle homeobox 2 | Always | In 2 conditions |
| PAK2p21 (RAC1) activated kinase 2 | Always | In 2 conditions |
| TUBTUB bipartite transcription factor | Always | In 1 condition |
| UBAP1Lubiquitin associated protein 1 like | Always | In 1 condition |
| B3GALNT2beta-1,3-N-acetylgalactosaminyltransferase 2 | Very often (80–99%) | In 2 conditions |
| B4GAT1beta-1,4-glucuronyltransferase 1 | Very often (80–99%) | In 1 condition |
| BMP4bone morphogenetic protein 4 | Very often (80–99%) | In 1 condition |
| COL11A1collagen type XI alpha 1 chain | Very often (80–99%) | In 4 conditions |
| COL18A1collagen type XVIII alpha 1 chain | Very often (80–99%) | In 2 conditions |
| COL2A1collagen type II alpha 1 chain | Very often (80–99%) | In 8 conditions |
| COL4A1collagen type IV alpha 1 chain | Very often (80–99%) | In 1 condition |
| CRPPACDP-L-ribitol pyrophosphorylase A | Very often (80–99%) | In 2 conditions |
| DAG1dystroglycan 1 | Very often (80–99%) | In 1 condition |
| FKRPfukutin related protein | Very often (80–99%) | In 4 conditions |
| FKTNfukutin | Very often (80–99%) | In 3 conditions |
| LARGE1LARGE xylosyl- and glucuronyltransferase 1 | Very often (80–99%) | In 2 conditions |
| POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Very often (80–99%) | In 2 conditions |
| POMGNT2protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) | Very often (80–99%) | In 1 condition |
| POMKprotein O-mannose kinase | Very often (80–99%) | In 2 conditions |
| POMT1protein O-mannosyltransferase 1 | Very often (80–99%) | In 3 conditions |
| POMT2protein O-mannosyltransferase 2 | Very often (80–99%) | In 3 conditions |
| RXYLT1ribitol xylosyltransferase 1 | Very often (80–99%) | In 1 condition |
| XYLT2xylosyltransferase 2 | Very often (80–99%) | In 2 conditions |
| ADAMTSL1ADAMTS like 1 | Often (30–79%) | In 1 condition |
| ALDH1A3aldehyde dehydrogenase 1 family member A3 | Often (30–79%) | In 1 condition |
| ARL6IP6ARF like GTPase 6 interacting protein 6 | Often (30–79%) | In 1 condition |
| CBScystathionine beta-synthase | Often (30–79%) | In 2 conditions |
| CHST14carbohydrate sulfotransferase 14 | Often (30–79%) | In 2 conditions |
| DSEdermatan sulfate epimerase | Often (30–79%) | In 1 condition |
| FASFas cell surface death receptor | Often (30–79%) | In 1 condition |
| FOXE3forkhead box E3 | Often (30–79%) | In 1 condition |
| FZD4frizzled class receptor 4 | Often (30–79%) | In 1 condition |
| GNA11G protein subunit alpha 11 | Often (30–79%) | In 1 condition |
| GZF1GDNF inducible zinc finger protein 1 | Often (30–79%) | In 1 condition |
Show 70 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 1 condition |
| HMX1H6 family homeobox 1 | Often (30–79%) | In 1 condition |
| LAMB2laminin subunit beta 2 | Often (30–79%) | In 2 conditions |
| LOXL3lysyl oxidase like 3 | Often (30–79%) | In 2 conditions |
| LRP2LDL receptor related protein 2 | Often (30–79%) | In 2 conditions |
| NSMCE2NSE2 SUMO ligase component of SMC5/6 complex | Often (30–79%) | In 2 conditions |
| P3H2prolyl 3-hydroxylase 2 | Often (30–79%) | In 1 condition |
| PTENphosphatase and tensin homolog | Often (30–79%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Often (30–79%) | In 1 condition |
| RS1retinoschisin 1 | Often (30–79%) | In 2 conditions |
| SETD2SET domain containing 2, histone lysine methyltransferase | Often (30–79%) | In 1 condition |
| SIX6SIX homeobox 6 | Often (30–79%) | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Often (30–79%) | In 1 condition |
| VCANversican | Often (30–79%) | In 1 condition |
| ZNF408zinc finger protein 408 | Often (30–79%) | In 1 condition |
| ADAMTSL4ADAMTS like 4 | Sometimes (5–29%) | In 1 condition |
| ALG12ALG12 alpha-1,6-mannosyltransferase | Sometimes (5–29%) | In 2 conditions |
| ALMS1ALMS1 centrosome and basal body associated protein | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 2 conditions |
| CABP4calcium binding protein 4 | Sometimes (5–29%) | In 1 condition |
| CACNA1Fcalcium voltage-gated channel subunit alpha1 F | Sometimes (5–29%) | In 1 condition |
| CHRDL1chordin like 1 | Sometimes (5–29%) | In 1 condition |
| COL9A1collagen type IX alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL9A3collagen type IX alpha 3 chain | Sometimes (5–29%) | In 1 condition |
| DNMT3BDNA methyltransferase 3 beta | Sometimes (5–29%) | In 1 condition |
| DUX4double homeobox 4 | Sometimes (5–29%) | In 1 condition |
| DUX4L1double homeobox 4 like 1 (pseudogene) | Sometimes (5–29%) | In 1 condition |
| FBN1fibrillin 1 | Sometimes (5–29%) | In 3 conditions |
| FRG1FSHD region gene 1 | Sometimes (5–29%) | In 1 condition |
| FZD5frizzled class receptor 5 | Sometimes (5–29%) | In 1 condition |
| GNAQG protein subunit alpha q | Sometimes (5–29%) | In 1 condition |
| HLA-Amajor histocompatibility complex, class I, A | Sometimes (5–29%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Sometimes (5–29%) | In 2 conditions |
| IPO8importin 8 | Sometimes (5–29%) | In 1 condition |
| KCNJ13potassium inwardly rectifying channel subfamily J member 13 | Sometimes (5–29%) | In 2 conditions |
| KIF11kinesin family member 11 | Sometimes (5–29%) | In 2 conditions |
| LCA5lebercilin LCA5 | Sometimes (5–29%) | In 1 condition |
| LRATlecithin retinol acyltransferase | Sometimes (5–29%) | In 1 condition |
| MAFMAF bZIP transcription factor | Sometimes (5–29%) | In 1 condition |
| MFRPmembrane frizzled-related protein | Sometimes (5–29%) | In 1 condition |
| NHSNHS actin remodeling regulator | Sometimes (5–29%) | In 1 condition |
| NRCAMneuronal cell adhesion molecule | Sometimes (5–29%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PAX2paired box 2 | Sometimes (5–29%) | In 1 condition |
| PAX6paired box 6 | Sometimes (5–29%) | In 2 conditions |
| PLOD1procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Sometimes (5–29%) | In 2 conditions |
| PRDM5PR/SET domain 5 | Sometimes (5–29%) | In 1 condition |
| PRPH2peripherin 2 | Sometimes (5–29%) | In 1 condition |
| RAI1retinoic acid induced 1 | Sometimes (5–29%) | In 2 conditions |
| RPE65retinoid isomerohydrolase RPE65 | Sometimes (5–29%) | In 1 condition |
| SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1 | Sometimes (5–29%) | In 1 condition |
| SPATA7spermatogenesis associated 7 | Sometimes (5–29%) | In 1 condition |
| TRPM3transient receptor potential cation channel subfamily M member 3 | Sometimes (5–29%) | In 1 condition |
| XRCC4X-ray repair cross complementing 4 | Sometimes (5–29%) | In 1 condition |
| YAP1Yes1 associated transcriptional regulator | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| ZNF469zinc finger protein 469 | Sometimes (5–29%) | In 1 condition |
| CCND1cyclin D1 | Rarely (1–4%) | In 1 condition |
| DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A | Rarely (1–4%) | In 2 conditions |
| GMPPBGDP-mannose pyrophosphorylase B | Rarely (1–4%) | In 1 condition |
| PTBP1polypyrimidine tract binding protein 1 | Rarely (1–4%) | In 1 condition |
| VHLvon Hippel-Lindau tumor suppressor | Rarely (1–4%) | In 1 condition |
| BEST1bestrophin 1 | Not recorded | In 2 conditions |
| CAPN5calpain 5 | Not recorded | In 1 condition |
| COL11A2collagen type XI alpha 2 chain | Not recorded | In 1 condition |
| CTNNB1catenin beta 1 | Not recorded | In 1 condition |
| LRP6LDL receptor related protein 6 | Not recorded | In 1 condition |
| TENM3teneurin transmembrane protein 3 | Not recorded | In 1 condition |
| TRAPPC2trafficking protein particle complex subunit 2 | Not recorded | In 1 condition |
| TUBGCP6tubulin gamma complex component 6 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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