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Gene

AICDA

activation induced cytidine deaminase

Summary

Cytogenetic location
12p13.31
Coordinates
Chromosome 12: 8,602,170–8,612,859 (GRCh38)
Exons
5 exons across 10.7 kb
Protein
198 amino acids
Also known as
HIGM2, CDA2, ARP2, AID
MANE Select transcript
ENST00000229335.11NM_020661.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hyper-IgM Syndromes

    • Hyper-IgM syndrome

      Defective antibody class switching caused by changes in CD40LG (X-linked), CD40, AICDA or UNG.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Immunoglobulin replacement is standard; CD40L and CD40 deficiency also need Pneumocystis prophylaxis, safe drinking water to prevent cryptosporidium and consideration of stem cell transplantation.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
    • Immunodeficiency Disease

      One of 170 genes linked to it

      Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

How AICDA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 12, with a bracket where AICDA sits. AICDA and 14 genes near it on chromosome 12, from 8,107,515 to 9,107,514.Chromosome 1212p13.31p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.338.2 Mb8.4 Mb8.6 Mb8.8 Mb9 MbCLEC4A: 8,123,617–8,138,607, forward strandCLEC4A: 8,138,140–8,175,320, forward strandZNF705A: 8,157,015–8,188,537, forward strandZNF705AFAM90A1: 8,221,260–8,227,621, reverse strandFAM90A1CLEC6A: 8,455,950–8,479,779, forward strandCLEC6ACLEC4D: 8,509,475–8,522,641, forward strandCLEC4DCLEC4E: 8,533,273–8,541,079, reverse strandCLEC4EAICDA: 8,602,170–8,612,859, reverse strandAICDAMFAP5: 8,637,346–8,672,519, reverse strandMFAP5RIMKLB: 8,681,483–8,783,095, forward strandRIMKLBA2ML1: 8,822,466–8,887,001, forward strandA2ML1PHC1: 8,913,824–8,944,860, forward strandPHC1M6PR: 8,940,358–8,951,856, reverse strandM6PRKLRG1: 8,950,044–9,165,627, forward strandKLRG1A2M: 9,067,664–9,116,229, reverse strandA2MDiagram of AICDA: 5 exons on the reverse strand of chromosome 12Exon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 17 known disease-causing sitesExon 2: 6 known disease-causing sitesExon 5: 8,602,170–8,604,337, 2,168 basesExon 4: 8,604,807–8,604,922, 116 basesExon 3: 8,605,215–8,605,485, 271 basesExon 2: 8,606,865–8,607,012, 148 basesExon 1: 8,612,760–8,612,859, 100 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 10.7 kb; 597 of those bases code for the protein.

How a genome test reads AICDA

30

positions in AICDA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 10.7 kb of AICDA, introns included, not only the 2.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AICDA gene: activation induced cytidine deaminase. Retrieved 16 October 2026, from https://dantelabs.com/genes/aicda

Vancouver

Dante Labs. AICDA gene: activation induced cytidine deaminase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/aicda

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