Trait

AA amyloidosis

Extracellular tissue deposition of fibrils that are composed of fragments of and/or intact serum amyloid A protein, a hepatic acute phase reactant.

HPO HP:4000041

Body system: Laboratory abnormality

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16 genes linked to AA amyloidosis

Changes in these genes cause rare conditions in which AA amyloidosis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
C4Acomplement C4A (Chido/Rodgers blood group)	Sometimes (5–29%)	In 1 condition
CCR1C-C motif chemokine receptor 1	Sometimes (5–29%)	In 1 condition
ERAP1endoplasmic reticulum aminopeptidase 1	Sometimes (5–29%)	In 1 condition
FASFas cell surface death receptor	Sometimes (5–29%)	In 1 condition
HLA-Bmajor histocompatibility complex, class I, B	Sometimes (5–29%)	In 1 condition
IFNGR1interferon gamma receptor 1	Sometimes (5–29%)	In 1 condition
IL10interleukin 10	Sometimes (5–29%)	In 1 condition
IL12Ainterleukin 12A	Sometimes (5–29%)	In 1 condition
IL12A-AS1IL12A antisense RNA 1	Sometimes (5–29%)	In 1 condition
IL23Rinterleukin 23 receptor	Sometimes (5–29%)	In 1 condition
KLRC4killer cell lectin like receptor C4	Sometimes (5–29%)	In 1 condition
MEFVMEFV innate immunity regulator, pyrin	Sometimes (5–29%)	In 1 condition
STAT4signal transducer and activator of transcription 4	Sometimes (5–29%)	In 1 condition
TLR4toll like receptor 4	Sometimes (5–29%)	In 1 condition
TNFRSF1ATNF receptor superfamily member 1A	Sometimes (5–29%)	In 1 condition
UBAC2UBA domain containing 2	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Amyloid deposition

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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