Trait
Recurrent canker sores
Clinical name: Recurrent aphthous stomatitis
Recurrent episodes of ulceration of the oral mucosa, typically presenting as painful, sharply circumscribed fibrin-covered mucosal defects with a hyperemic border.
Summary
- Also called
- Recurrent oral aphthae
Reference genomeGRCh38hg38
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Get my Genome Test49 genes linked to Recurrent canker sores
Changes in these genes cause rare conditions in which Recurrent canker sores is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CEBPECCAAT enhancer binding protein epsilon | Always | In 1 condition |
| HYOU1hypoxia up-regulated 1 | Always | In 1 condition |
| IKZF2IKAROS family zinc finger 2 | Always | In 1 condition |
| MALT1MALT1 paracaspase | Always | In 1 condition |
| NCF4neutrophil cytosolic factor 4 | Always | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Always | In 1 condition |
| SEC61A1SEC61 translocon subunit alpha 1 | Always | In 1 condition |
| TOP2BDNA topoisomerase II beta | Always | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Very often (80–99%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Very often (80–99%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Very often (80–99%) | In 1 condition |
| FASFas cell surface death receptor | Very often (80–99%) | In 2 conditions |
| HLA-Bmajor histocompatibility complex, class I, B | Very often (80–99%) | In 2 conditions |
| IFNGR1interferon gamma receptor 1 | Very often (80–99%) | In 1 condition |
| IL10interleukin 10 | Very often (80–99%) | In 1 condition |
| IL12Ainterleukin 12A | Very often (80–99%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Very often (80–99%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Very often (80–99%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Very often (80–99%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Very often (80–99%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Very often (80–99%) | In 1 condition |
| TLR4toll like receptor 4 | Very often (80–99%) | In 1 condition |
| UBAC2UBA domain containing 2 | Very often (80–99%) | In 1 condition |
| CARMIL2capping protein regulator and myosin 1 linker 2 | Often (30–79%) | In 1 condition |
| CLPBClpB family mitochondrial disaggregase | Often (30–79%) | In 1 condition |
| ELANEelastase, neutrophil expressed | Often (30–79%) | In 1 condition |
| GFI1growth factor independent 1 transcriptional repressor | Often (30–79%) | In 1 condition |
| IL17RCinterleukin 17 receptor C | Often (30–79%) | In 1 condition |
| MVKmevalonate kinase | Often (30–79%) | In 1 condition |
| RIN2Ras and Rab interactor 2 | Often (30–79%) | In 1 condition |
| SRP19signal recognition particle 19 | Often (30–79%) | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Often (30–79%) | In 1 condition |
| TICAM1TIR domain containing adaptor molecule 1 | Often (30–79%) | In 1 condition |
| WDR1WD repeat domain 1 | Often (30–79%) | In 1 condition |
| DCLRE1CDNA cross-link repair 1C | Sometimes (5–29%) | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Sometimes (5–29%) | In 2 conditions |
| RNF125ring finger protein 125 | Sometimes (5–29%) | In 1 condition |
| RORCRAR related orphan receptor C | Sometimes (5–29%) | In 1 condition |
| STK4serine/threonine kinase 4 | Sometimes (5–29%) | In 1 condition |
| TLR8toll like receptor 8 | Sometimes (5–29%) | In 1 condition |
Show 9 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CASP10caspase 10 | Rarely (1–4%) | In 1 condition |
| FASLGFas ligand | Rarely (1–4%) | In 1 condition |
| HLA-DQA1major histocompatibility complex, class II, DQ alpha 1 | Not recorded | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Not recorded | In 1 condition |
| IL6interleukin 6 | Not recorded | In 1 condition |
| NLRP12NLR family pyrin domain containing 12 | Not recorded | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Not recorded | In 1 condition |
| ORAI1ORAI calcium release-activated calcium modulator 1 | Not recorded | In 1 condition |
| PRKDCprotein kinase, DNA-activated, catalytic subunit | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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