Trait
Episodic fever
Clinical name: Recurrent fever
Periodic (episodic or recurrent) bouts of fever.
Summary
- Also called
- Increased body temperature, episodic, Intermittent fever, Hyperthermia, episodic
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test110 genes linked to Episodic fever
Changes in these genes cause rare conditions in which Episodic fever is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADAadenosine deaminase | Always | In 1 condition |
| ASAH1N-acylsphingosine amidohydrolase 1 | Always | In 2 conditions |
| ATP5F1BATP synthase F1 subunit beta | Always | In 1 condition |
| C3complement C3 | Always | In 1 condition |
| CD70CD70 molecule | Always | In 1 condition |
| CEBPECCAAT enhancer binding protein epsilon | Always | In 1 condition |
| DCLRE1CDNA cross-link repair 1C | Always | In 1 condition |
| DNASE2deoxyribonuclease 2, lysosomal | Always | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Always | In 1 condition |
| ELF4E74 like ETS transcription factor 4 | Always | In 1 condition |
| HEPHL1hephaestin like 1 | Always | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Always | In 1 condition |
| IRF4interferon regulatory factor 4 | Always | In 1 condition |
| ITKIL2 inducible T cell kinase | Always | In 1 condition |
| LPIN2lipin 2 | Always | In 1 condition |
| MAN2B2mannosidase alpha class 2B member 2 | Always | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Always | In 4 conditions |
| MVKmevalonate kinase | Always | In 2 conditions |
| NLRC4NLR family CARD domain containing 4 | Always | In 1 condition |
| NLRP1NLR family pyrin domain containing 1 | Always | In 1 condition |
| NLRP12NLR family pyrin domain containing 12 | Always | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Always | In 3 conditions |
| NTRK1neurotrophic receptor tyrosine kinase 1 | Always | In 2 conditions |
| OFD1OFD1 centriole and centriolar satellite protein | Always | In 1 condition |
| OTULINOTU deubiquitinase with linear linkage specificity | Always | In 1 condition |
| PRF1perforin 1 | Always | In 1 condition |
| PRKCDprotein kinase C delta | Always | In 1 condition |
| PSMB8proteasome 20S subunit beta 8 | Always | In 1 condition |
| PSMG2proteasome assembly chaperone 2 | Always | In 1 condition |
| RAG1recombination activating 1 | Always | In 1 condition |
| RAG2recombination activating 2 | Always | In 1 condition |
| RELREL proto-oncogene, NF-kB subunit | Always | In 1 condition |
| RNF31ring finger protein 31 | Always | In 1 condition |
| SH2D1ASH2 domain containing 1A | Always | In 1 condition |
| SHARPINSHANK associated RH domain interactor | Always | In 1 condition |
| SLC19A1solute carrier family 19 member 1 | Always | In 1 condition |
| SLC41A1solute carrier family 41 member 1 | Always | In 1 condition |
| STX11syntaxin 11 | Always | In 1 condition |
| XIAPX-linked inhibitor of apoptosis | Always | In 3 conditions |
| C2orf69chromosome 2 open reading frame 69 | Very often (80–99%) | In 1 condition |
Show 70 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| COG7component of oligomeric golgi complex 7 | Very often (80–99%) | In 1 condition |
| HMOX1heme oxygenase 1 | Very often (80–99%) | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Very often (80–99%) | In 1 condition |
| LIFRLIF receptor subunit alpha | Very often (80–99%) | In 2 conditions |
| RIPK1receptor interacting serine/threonine kinase 1 | Very often (80–99%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Very often (80–99%) | In 2 conditions |
| UBA1ubiquitin like modifier activating enzyme 1 | Very often (80–99%) | In 1 condition |
| ZFHX2zinc finger homeobox 2 | Very often (80–99%) | In 1 condition |
| ADA2adenosine deaminase 2 | Often (30–79%) | In 1 condition |
| BCAP31B cell receptor associated protein 31 | Often (30–79%) | In 1 condition |
| CBLBCbl proto-oncogene B | Often (30–79%) | In 1 condition |
| COG6component of oligomeric golgi complex 6 | Often (30–79%) | In 1 condition |
| ELANEelastase, neutrophil expressed | Often (30–79%) | In 1 condition |
| MCTS1MCTS1 re-initiation and release factor | Often (30–79%) | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Often (30–79%) | In 1 condition |
| PMP22peripheral myelin protein 22 | Often (30–79%) | In 1 condition |
| RBCK1RANBP2-type and C3HC4-type zinc finger containing 1 | Often (30–79%) | In 1 condition |
| RNF168ring finger protein 168 | Often (30–79%) | In 1 condition |
| SLC35C1solute carrier family 35 member C1 | Often (30–79%) | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Often (30–79%) | In 1 condition |
| STAT2signal transducer and activator of transcription 2 | Often (30–79%) | In 1 condition |
| STING1stimulator of interferon response cGAMP interactor 1 | Often (30–79%) | In 1 condition |
| STK4serine/threonine kinase 4 | Often (30–79%) | In 1 condition |
| SYKspleen associated tyrosine kinase | Often (30–79%) | In 1 condition |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 1 condition |
| TLR7toll like receptor 7 | Often (30–79%) | In 1 condition |
| WDR1WD repeat domain 1 | Often (30–79%) | In 1 condition |
| ALPK1alpha kinase 1 | Sometimes (5–29%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Sometimes (5–29%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Sometimes (5–29%) | In 1 condition |
| DEF6DEF6 guanine nucleotide exchange factor | Sometimes (5–29%) | In 1 condition |
| DOCK2dedicator of cytokinesis 2 | Sometimes (5–29%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Sometimes (5–29%) | In 1 condition |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 1 condition |
| FOCADfocadhesin | Sometimes (5–29%) | In 1 condition |
| H4C5H4 clustered histone 5 | Sometimes (5–29%) | In 1 condition |
| HBBhemoglobin subunit beta | Sometimes (5–29%) | In 2 conditions |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| HNRNPKheterogeneous nuclear ribonucleoprotein K | Sometimes (5–29%) | In 2 conditions |
| IFNGR1interferon gamma receptor 1 | Sometimes (5–29%) | In 1 condition |
| IL10interleukin 10 | Sometimes (5–29%) | In 1 condition |
| IL12Ainterleukin 12A | Sometimes (5–29%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Sometimes (5–29%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Sometimes (5–29%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Sometimes (5–29%) | In 1 condition |
| NAXDNAD(P)HX dehydratase | Sometimes (5–29%) | In 1 condition |
| NGFnerve growth factor | Sometimes (5–29%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Sometimes (5–29%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Sometimes (5–29%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Sometimes (5–29%) | In 1 condition |
| TLR4toll like receptor 4 | Sometimes (5–29%) | In 1 condition |
| TNFAIP3TNF alpha induced protein 3 | Sometimes (5–29%) | In 1 condition |
| UBAC2UBA domain containing 2 | Sometimes (5–29%) | In 1 condition |
| ZNFX1zinc finger NFX1-type containing 1 | Sometimes (5–29%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| CRLF1cytokine receptor like factor 1 | Not recorded | In 1 condition |
| CYP11B2cytochrome P450 family 11 subfamily B member 2 | Not recorded | In 1 condition |
| CYP21A2cytochrome P450 family 21 subfamily A member 2 | Not recorded | In 1 condition |
| ELP1elongator acetyltransferase complex subunit 1 | Not recorded | In 1 condition |
| GALCgalactosylceramidase | Not recorded | In 1 condition |
| GCH1GTP cyclohydrolase 1 | Not recorded | In 1 condition |
| IBA57iron-sulfur cluster assembly factor IBA57 | Not recorded | In 1 condition |
| ORAI1ORAI calcium release-activated calcium modulator 1 | Not recorded | In 1 condition |
| PEX6peroxisomal biogenesis factor 6 | Not recorded | In 1 condition |
| PSMB4proteasome 20S subunit beta 4 | Not recorded | In 1 condition |
| PTS6-pyruvoyltetrahydropterin synthase | Not recorded | In 1 condition |
| QDPRquinoid dihydropteridine reductase | Not recorded | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Not recorded | In 1 condition |
| STIM1stromal interaction molecule 1 | Not recorded | In 1 condition |
| STXBP2syntaxin binding protein 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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