Trait
Hypersplenism
A malfunctioning of the spleen in which it prematurely destroys red blood cells.
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Hypersplenism, and the rest of your genome, with one test.
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Get my Genome Test22 genes linked to Hypersplenism
Changes in these genes cause rare conditions in which Hypersplenism is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CILK1ciliogenesis associated kinase 1 | Always | In 1 condition |
| ITCHitchy E3 ubiquitin protein ligase | Always | In 2 conditions |
| KLF1KLF transcription factor 1 | Always | In 1 condition |
| LIPAlipase A, lysosomal acid type | Always | In 1 condition |
| GBA1glucosylceramidase beta 1 | Very often (80–99%) | In 2 conditions |
| SCARB2scavenger receptor class B member 2 | Very often (80–99%) | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Very often (80–99%) | In 2 conditions |
| CASP10caspase 10 | Often (30–79%) | In 1 condition |
| DZIP1LDAZ interacting zinc finger protein 1 like | Often (30–79%) | In 1 condition |
| FASFas cell surface death receptor | Often (30–79%) | In 1 condition |
| FASLGFas ligand | Often (30–79%) | In 1 condition |
| HBBhemoglobin subunit beta | Often (30–79%) | In 2 conditions |
| PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin | Often (30–79%) | In 1 condition |
| PSAPprosaposin | Often (30–79%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Sometimes (5–29%) | In 1 condition |
| CBLCbl proto-oncogene | Sometimes (5–29%) | In 1 condition |
| MED12mediator complex subunit 12 | Sometimes (5–29%) | In 1 condition |
| NOTCH1notch receptor 1 | Sometimes (5–29%) | In 1 condition |
| RUNX1RUNX family transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| SRSF2serine and arginine rich splicing factor 2 | Sometimes (5–29%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Sometimes (5–29%) | In 1 condition |
| TULP3TUB like protein 3 | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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