Trait
Fluid retention
Clinical name: Edema
An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.
Summary
- Also called
- Water retention, Dropsy, Hydrops, Oedema
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Fluid retention, and the rest of your genome, with one test.
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Get my Genome Test227 genes linked to Fluid retention
Changes in these genes cause rare conditions in which Fluid retention is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALBalbumin | Always | In 2 conditions |
| ALG8ALG8 alpha-1,3-glucosyltransferase | Always | In 2 conditions |
| ATP7BATPase copper transporting beta | Always | In 1 condition |
| CCDC88Acoiled-coil and HOOK domain protein 88A | Always | In 1 condition |
| DCLRE1CDNA cross-link repair 1C | Always | In 2 conditions |
| IFT140intraflagellar transport 140 | Always | In 1 condition |
| MRPS16mitochondrial ribosomal protein S16 | Always | In 1 condition |
| MYO1Emyosin IE | Always | In 2 conditions |
| OTULINOTU deubiquitinase with linear linkage specificity | Always | In 1 condition |
| PDSS2decaprenyl diphosphate synthase subunit 2 | Always | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Always | In 1 condition |
| PSMG2proteasome assembly chaperone 2 | Always | In 1 condition |
| PTPROprotein tyrosine phosphatase receptor type O | Always | In 2 conditions |
| RAG1recombination activating 1 | Always | In 2 conditions |
| RAG2recombination activating 2 | Always | In 2 conditions |
| SCARB2scavenger receptor class B member 2 | Always | In 1 condition |
| SPOUT1SPOUT domain containing methyltransferase 1 | Always | In 1 condition |
| VPS51VPS51 subunit of GARP complex | Always | In 1 condition |
| ACTN4actinin alpha 4 | Very often (80–99%) | In 2 conditions |
| AGBL1AGBL carboxypeptidase 1 | Very often (80–99%) | In 1 condition |
| ANKFY1ankyrin repeat and FYVE domain containing 1 | Very often (80–99%) | In 1 condition |
| ANLNanillin, actin binding protein | Very often (80–99%) | In 1 condition |
| APOL1apolipoprotein L1 | Very often (80–99%) | In 1 condition |
| ARHGAP24Rho GTPase activating protein 24 | Very often (80–99%) | In 1 condition |
| ARHGDIARho GDP dissociation inhibitor alpha | Very often (80–99%) | In 2 conditions |
| AVILadvillin | Very often (80–99%) | In 1 condition |
| CD2APCD2 associated protein | Very often (80–99%) | In 1 condition |
| CD55CD55 molecule (Cromer blood group) | Very often (80–99%) | In 1 condition |
| COL4A3collagen type IV alpha 3 chain | Very often (80–99%) | In 1 condition |
| COL8A2collagen type VIII alpha 2 chain | Very often (80–99%) | In 1 condition |
| COQ8Bcoenzyme Q8B | Very often (80–99%) | In 2 conditions |
| CRB2crumbs cell polarity complex component 2 | Very often (80–99%) | In 1 condition |
| DAAM2dishevelled associated activator of morphogenesis 2 | Very often (80–99%) | In 1 condition |
| EMP2epithelial membrane protein 2 | Very often (80–99%) | In 1 condition |
| GAPVD1GTPase activating protein and VPS9 domains 1 | Very often (80–99%) | In 1 condition |
| INF2inverted formin 2 | Very often (80–99%) | In 1 condition |
| KANK2KN motif and ankyrin repeat domains 2 | Very often (80–99%) | In 1 condition |
| KRT2keratin 2 | Very often (80–99%) | In 1 condition |
| LAMA5laminin subunit alpha 5 | Very often (80–99%) | In 1 condition |
| MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 | Very often (80–99%) | In 1 condition |
Show 187 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MAPRE2microtubule associated protein RP/EB family member 2 | Very often (80–99%) | In 1 condition |
| NPHS1NPHS1 adhesion molecule, nephrin | Very often (80–99%) | In 2 conditions |
| NPHS2NPHS2 stomatin family member, podocin | Very often (80–99%) | In 2 conditions |
| NUP107nucleoporin 107 | Very often (80–99%) | In 2 conditions |
| NUP133nucleoporin 133 | Very often (80–99%) | In 1 condition |
| NUP160nucleoporin 160 | Very often (80–99%) | In 1 condition |
| NUP205nucleoporin 205 | Very often (80–99%) | In 1 condition |
| NUP37nucleoporin 37 | Very often (80–99%) | In 1 condition |
| NUP85nucleoporin 85 | Very often (80–99%) | In 1 condition |
| NUP93nucleoporin 93 | Very often (80–99%) | In 1 condition |
| PAX2paired box 2 | Very often (80–99%) | In 3 conditions |
| PLCE1phospholipase C epsilon 1 | Very often (80–99%) | In 2 conditions |
| SLC4A11solute carrier family 4 member 11 | Very often (80–99%) | In 1 condition |
| TBC1D8BTBC1 domain family member 8B | Very often (80–99%) | In 1 condition |
| TCF4transcription factor 4 | Very often (80–99%) | In 1 condition |
| TRPC6transient receptor potential cation channel subfamily C member 6 | Very often (80–99%) | In 1 condition |
| TUBBtubulin beta class I | Very often (80–99%) | In 1 condition |
| WT1WT1 transcription factor | Very often (80–99%) | In 1 condition |
| ZEB1zinc finger E-box binding homeobox 1 | Very often (80–99%) | In 1 condition |
| ABCC9ATP binding cassette subfamily C member 9 | Often (30–79%) | In 1 condition |
| ACTC1actin alpha cardiac muscle 1 | Often (30–79%) | In 1 condition |
| ACTN2actinin alpha 2 | Often (30–79%) | In 1 condition |
| ADAadenosine deaminase | Often (30–79%) | In 1 condition |
| ANKRD1ankyrin repeat domain 1 | Often (30–79%) | In 1 condition |
| BAG3BAG cochaperone 3 | Often (30–79%) | In 1 condition |
| BAG5BAG cochaperone 5 | Often (30–79%) | In 1 condition |
| CAP2cyclase associated actin cytoskeleton regulatory protein 2 | Often (30–79%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Often (30–79%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Often (30–79%) | In 2 conditions |
| CRYABcrystallin alpha B | Often (30–79%) | In 1 condition |
| CSRP3cysteine and glycine rich protein 3 | Often (30–79%) | In 1 condition |
| DESdesmin | Often (30–79%) | In 1 condition |
| DGKEdiacylglycerol kinase epsilon | Often (30–79%) | In 1 condition |
| DMDdystrophin | Often (30–79%) | In 1 condition |
| DOLKdolichol kinase | Often (30–79%) | In 1 condition |
| DSG2desmoglein 2 | Often (30–79%) | In 1 condition |
| DSPdesmoplakin | Often (30–79%) | In 2 conditions |
| FHL2four and a half LIM domains 2 | Often (30–79%) | In 1 condition |
| FKTNfukutin | Often (30–79%) | In 1 condition |
| FLNCfilamin C | Often (30–79%) | In 1 condition |
| GATAD1GATA zinc finger domain containing 1 | Often (30–79%) | In 1 condition |
| GET3guided entry of tail-anchored proteins factor 3, ATPase | Often (30–79%) | In 1 condition |
| GNA14G protein subunit alpha 14 | Often (30–79%) | In 1 condition |
| GSNgelsolin | Often (30–79%) | In 1 condition |
| HAND2heart and neural crest derivatives expressed 2 | Often (30–79%) | In 1 condition |
| HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Often (30–79%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Often (30–79%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Often (30–79%) | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Often (30–79%) | In 1 condition |
| IL7Rinterleukin 7 receptor | Often (30–79%) | In 1 condition |
| IRAK1interleukin 1 receptor associated kinase 1 | Often (30–79%) | In 1 condition |
| JPH2junctophilin 2 | Often (30–79%) | In 1 condition |
| KIF11kinesin family member 11 | Often (30–79%) | In 1 condition |
| LAMA4laminin subunit alpha 4 | Often (30–79%) | In 1 condition |
| LDB3LIM domain binding 3 | Often (30–79%) | In 1 condition |
| LMNAlamin A/C | Often (30–79%) | In 1 condition |
| LMOD2leiomodin 2 | Often (30–79%) | In 1 condition |
| LPIN2lipin 2 | Often (30–79%) | In 1 condition |
| MAGEL2MAGE family member L2 | Often (30–79%) | In 1 condition |
| MKRN3makorin ring finger protein 3 | Often (30–79%) | In 1 condition |
| MPImannose phosphate isomerase | Often (30–79%) | In 2 conditions |
| MVKmevalonate kinase | Often (30–79%) | In 1 condition |
| MYBPC3myosin binding protein C3 | Often (30–79%) | In 1 condition |
| MYH6myosin heavy chain 6 | Often (30–79%) | In 1 condition |
| MYH7myosin heavy chain 7 | Often (30–79%) | In 1 condition |
| MYPNmyopalladin | Often (30–79%) | In 1 condition |
| NEU1neuraminidase 1 | Often (30–79%) | In 1 condition |
| NEXNnexilin F-actin binding protein | Often (30–79%) | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Often (30–79%) | In 1 condition |
| NPAP1nuclear pore associated protein 1 | Often (30–79%) | In 1 condition |
| NRAPnebulin related anchoring protein | Often (30–79%) | In 1 condition |
| NUDCD3NudC domain containing 3 | Often (30–79%) | In 1 condition |
| PLNphospholamban | Often (30–79%) | In 1 condition |
| PPCSphosphopantothenoylcysteine synthetase | Often (30–79%) | In 1 condition |
| PRDM16PR/SET domain 16 | Often (30–79%) | In 1 condition |
| PRF1perforin 1 | Often (30–79%) | In 1 condition |
| PSAT1phosphoserine aminotransferase 1 | Often (30–79%) | In 1 condition |
| PSEN1presenilin 1 | Often (30–79%) | In 1 condition |
| PSEN2presenilin 2 | Often (30–79%) | In 1 condition |
| PSMB10proteasome 20S subunit beta 10 | Often (30–79%) | In 1 condition |
| PWAR1Prader Willi/Angelman region RNA 1 | Often (30–79%) | In 1 condition |
| PWRN1Prader-Willi region non-protein coding RNA 1 | Often (30–79%) | In 1 condition |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| RBM20RNA binding motif protein 20 | Often (30–79%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Often (30–79%) | In 1 condition |
| RPL3Lribosomal protein L3 like | Often (30–79%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Often (30–79%) | In 1 condition |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Often (30–79%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Often (30–79%) | In 1 condition |
| SGCDsarcoglycan delta | Often (30–79%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Often (30–79%) | In 1 condition |
| SNORD115-1small nucleolar RNA, C/D box 115-1 | Often (30–79%) | In 1 condition |
| SNORD116-1small nucleolar RNA, C/D box 116-1 | Often (30–79%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Often (30–79%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Often (30–79%) | In 1 condition |
| STX11syntaxin 11 | Often (30–79%) | In 1 condition |
| TAF1ATATA-box binding protein associated factor, RNA polymerase I subunit A | Often (30–79%) | In 1 condition |
| TAFAZZINtafazzin, phospholipid-lysophospholipid transacylase | Often (30–79%) | In 1 condition |
| TALDO1transaldolase 1 | Often (30–79%) | In 1 condition |
| TCAPtitin-cap | Often (30–79%) | In 1 condition |
| TMPOthymopoietin | Often (30–79%) | In 1 condition |
| TNNC1troponin C1, slow skeletal and cardiac type | Often (30–79%) | In 1 condition |
| TNNI3troponin I3, cardiac type | Often (30–79%) | In 1 condition |
| TNNT2troponin T2, cardiac type | Often (30–79%) | In 1 condition |
| TPM1tropomyosin 1 | Often (30–79%) | In 1 condition |
| TPRKBTP53RK binding protein | Often (30–79%) | In 1 condition |
| TTNtitin | Often (30–79%) | In 1 condition |
| TXNRD2thioredoxin reductase 2 | Often (30–79%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| VCLvinculin | Often (30–79%) | In 1 condition |
| VEZF1vascular endothelial zinc finger 1 | Often (30–79%) | In 1 condition |
| ABCC6ATP binding cassette subfamily C member 6 | Sometimes (5–29%) | In 1 condition |
| ACAT1acetyl-CoA acetyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| AGGF1angiogenic factor with G-patch and FHA domains 1 | Sometimes (5–29%) | In 1 condition |
| B4GALT1beta-1,4-galactosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Sometimes (5–29%) | In 1 condition |
| CD28CD28 molecule | Sometimes (5–29%) | In 2 conditions |
| CFTRCF transmembrane conductance regulator | Sometimes (5–29%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Sometimes (5–29%) | In 2 conditions |
| ENGendoglin | Sometimes (5–29%) | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Sometimes (5–29%) | In 1 condition |
| FECHferrochelatase | Sometimes (5–29%) | In 2 conditions |
| GNAQG protein subunit alpha q | Sometimes (5–29%) | In 1 condition |
| HMGCL3-hydroxy-3-methylglutaryl-CoA lyase | Sometimes (5–29%) | In 1 condition |
| JAG1jagged canonical Notch ligand 1 | Sometimes (5–29%) | In 1 condition |
| KCNN4potassium calcium-activated channel subfamily N member 4 | Sometimes (5–29%) | In 1 condition |
| LAMA3laminin subunit alpha 3 | Sometimes (5–29%) | In 1 condition |
| LAMB3laminin subunit beta 3 | Sometimes (5–29%) | In 1 condition |
| LAMC2laminin subunit gamma 2 | Sometimes (5–29%) | In 1 condition |
| LYSTlysosomal trafficking regulator | Sometimes (5–29%) | In 1 condition |
| MOGSmannosyl-oligosaccharide glucosidase | Sometimes (5–29%) | In 1 condition |
| PBX1PBX homeobox 1 | Sometimes (5–29%) | In 1 condition |
| PIEZO1piezo type mechanosensitive ion channel component 1 (Er blood group) | Sometimes (5–29%) | In 2 conditions |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| PMM2phosphomannomutase 2 | Sometimes (5–29%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| SLC4A1solute carrier family 4 member 1 (Diego blood group) | Sometimes (5–29%) | In 1 condition |
| SMAD4SMAD family member 4 | Sometimes (5–29%) | In 1 condition |
| TNFRSF1BTNF receptor superfamily member 1B | Sometimes (5–29%) | In 2 conditions |
| UBR1ubiquitin protein ligase E3 component n-recognin 1 | Sometimes (5–29%) | In 1 condition |
| ZNFX1zinc finger NFX1-type containing 1 | Sometimes (5–29%) | In 1 condition |
| ACBD6acyl-CoA binding domain containing 6 | Rarely (1–4%) | In 1 condition |
| ALG12ALG12 alpha-1,6-mannosyltransferase | Rarely (1–4%) | In 2 conditions |
| DUOX2dual oxidase 2 | Rarely (1–4%) | In 1 condition |
| GATA1GATA binding protein 1 | Rarely (1–4%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Rarely (1–4%) | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Rarely (1–4%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Rarely (1–4%) | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Rarely (1–4%) | In 1 condition |
| TSHRthyroid stimulating hormone receptor | Rarely (1–4%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Rarely (1–4%) | In 1 condition |
| URODuroporphyrinogen decarboxylase | Rarely (1–4%) | In 1 condition |
| UROSuroporphyrinogen III synthase | Rarely (1–4%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Not recorded | In 1 condition |
| BLTP1bridge-like lipid transfer protein family member 1 | Not recorded | In 1 condition |
| BPTFbromodomain PHD finger transcription factor | Not recorded | In 1 condition |
| BSNDbarttin CLCNK type accessory subunit beta | Not recorded | In 1 condition |
| CHRNA1cholinergic receptor nicotinic alpha 1 subunit | Not recorded | In 1 condition |
| CHRNDcholinergic receptor nicotinic delta subunit | Not recorded | In 1 condition |
| CHRNGcholinergic receptor nicotinic gamma subunit | Not recorded | In 1 condition |
| CLCNKAchloride voltage-gated channel Ka | Not recorded | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Not recorded | In 1 condition |
| DIS3L2DIS3 like 3'-5' exoribonuclease 2 | Not recorded | In 1 condition |
| EBPEBP cholestenol delta-isomerase | Not recorded | In 1 condition |
| EPHB4EPH receptor B4 | Not recorded | In 1 condition |
| ERBB3erb-b2 receptor tyrosine kinase 3 | Not recorded | In 1 condition |
| ERCC5ERCC excision repair 5, endonuclease | Not recorded | In 1 condition |
| FGAfibrinogen alpha chain | Not recorded | In 1 condition |
| GBE11,4-alpha-glucan branching enzyme 1 | Not recorded | In 1 condition |
| GLE1GLE1 RNA export mediator | Not recorded | In 1 condition |
| IL6interleukin 6 | Not recorded | In 1 condition |
| INPPL1inositol polyphosphate phosphatase like 1 | Not recorded | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Not recorded | In 1 condition |
| KRT13keratin 13 | Not recorded | In 1 condition |
| LAMB2laminin subunit beta 2 | Not recorded | In 1 condition |
| MKKSMKKS centrosomal shuttling protein | Not recorded | In 1 condition |
| MRPS22mitochondrial ribosomal protein S22 | Not recorded | In 1 condition |
| NR2E3nuclear receptor subfamily 2 group E member 3 | Not recorded | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Not recorded | In 1 condition |
| OSGEPO-sialoglycoprotein endopeptidase | Not recorded | In 1 condition |
| PLD1phospholipase D1 | Not recorded | In 1 condition |
| SGPL1sphingosine-1-phosphate lyase 1 | Not recorded | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Not recorded | In 1 condition |
| TREX1three prime repair exonuclease 1 | Not recorded | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Not recorded | In 1 condition |
| ZNHIT3zinc finger HIT-type containing 3 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Fluid around lungs86 genes
- Swelling caused by excess lymph fluid under skin75 genes
- Hydrops fetalis71 genes
- Increased nuchal translucency66 genes
- Fluid accumulation in lower limbs53 genes
- Joint swelling53 genes
- Facial puffiness35 genes
- Brain swelling32 genes
- Excess fluid in lungs30 genes
- Generalized edema18 genes
- Edema of the dorsum of hands16 genes
- Angioedema13 genes
- Corneal stromal edema13 genes
- Peripheral edema11 genes
- Laryngeal edema5 genes
- Fetal skin edema4 genes
- Genital edema4 genes
- Peau d'orange4 genes
- Throat swelling3 genes
- Intestinal edema2 genes
- Tongue edema2 genes
- Hyperkeratosis over edematous areas1 gene
- Hypoproteinemic edema1 gene
- Muscular edema1 gene
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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