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Gene

PTPRO

protein tyrosine phosphatase receptor type O

Summary

Cytogenetic location
12p12.3
Coordinates
Chromosome 12: 15,322,508–15,598,331 (GRCh38)
Exons
27 exons across 275.8 kb
Protein
1,216 amino acids
Also known as
PTPU2, GLEPP1, PTP-U2, PTP-oc, NPHS6
MANE Select transcript
ENST00000281171.9NM_030667.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Nephrotic Syndrome

    • Nephrosis

      Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.

      • 2 GenCC submitters rate it definitive or strong

How PTPRO is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where PTPRO sits. PTPRO and 6 genes near it on chromosome 12, from 14,960,420 to 15,960,419.Chromosome 1212p12.3p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3315 Mb15.2 Mb15.4 Mb15.6 Mb15.8 MbARHGDIB: 14,942,009–14,961,985, reverse strandARHGDIBPDE6H: 14,949,827–14,982,699, forward strandPDE6HRERG: 15,107,783–15,390,485, reverse strandRERGPTPRO: 15,322,508–15,598,331, forward strandPTPROEPS8: 15,617,906–15,882,330, reverse strandEPS8STRAP: 15,882,000–15,904,448, forward strandSTRAPDERA: 15,911,220–16,037,381, forward strandDERADiagram of PTPRO: 27 exons on the forward strand of chromosome 12Exon 9: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 1: 15,322,508–15,322,801, 294 basesExon 2: 15,483,974–15,484,247, 274 basesExon 3: 15,497,245–15,497,403, 159 basesExon 4: 15,499,442–15,499,594, 153 basesExon 5: 15,501,620–15,502,063, 444 basesExon 6: 15,503,908–15,504,069, 162 basesExon 7: 15,508,571–15,508,767, 197 basesExon 8: 15,515,498–15,515,618, 121 basesExon 9: 15,516,763–15,516,956, 194 basesExon 10: 15,520,201–15,520,312, 112 basesExon 11: 15,524,814–15,524,965, 152 basesExon 12: 15,526,142–15,526,262, 121 basesExon 13: 15,546,569–15,546,708, 140 basesExon 14: 15,549,094–15,549,226, 133 basesExon 15: 15,551,551–15,551,671, 121 basesExon 16: 15,557,455–15,557,523, 69 basesExon 17: 15,560,193–15,560,276, 84 basesExon 18: 15,565,593–15,565,628, 36 basesExon 19: 15,569,417–15,569,498, 82 basesExon 20: 15,578,853–15,578,943, 91 basesExon 21: 15,580,039–15,580,115, 77 basesExon 22: 15,580,697–15,580,831, 135 basesExon 23: 15,581,679–15,581,801, 123 basesExon 24: 15,586,897–15,587,051, 155 basesExon 25: 15,589,455–15,589,590, 136 basesExon 26: 15,594,937–15,595,057, 121 basesExon 27: 15,596,090–15,598,331, 2,242 bases1510152025275′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.1 kb of the gene's 275.8 kb; 3,651 of those bases code for the protein.

How a genome test reads PTPRO

3

positions in PTPRO where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 275.8 kb of PTPRO, introns included, not only the 6.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PTPRO gene: protein tyrosine phosphatase receptor type O. Retrieved 16 October 2026, from https://dantelabs.com/genes/ptpro

Vancouver

Dante Labs. PTPRO gene: protein tyrosine phosphatase receptor type O [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ptpro

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