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Gene

SCARB2

scavenger receptor class B member 2

Summary

Cytogenetic location
4q21.1
Coordinates
Chromosome 4: 76,158,737–76,213,824 (GRCh38)
Exons
12 exons across 55.1 kb
Protein
478 amino acids
Also known as
HLGP85, LIMPII, SR-BII, LIMP-2
Previous symbols
CD36L2
MANE Select transcript
ENST00000264896.8NM_005506.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • ClinGen rates the link definitive
        • 5 GenCC submitters rate it definitive or strong

    How SCARB2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 4, with a bracket where SCARB2 sits. SCARB2 and 15 genes near it on chromosome 4, from 75,686,281 to 76,686,280.Chromosome 44q21.1p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.275.8 Mb76 Mb76.2 Mb76.4 Mb76.6 MbG3BP2: 75,641,849–75,726,301, reverse strandG3BP2USO1: 75,724,522–75,814,290, forward strandUSO1PPEF2: 75,859,864–75,902,571, reverse strandPPEF2NAAA: 75,910,655–75,941,118, reverse strandNAAASDAD1: 75,940,950–75,990,962, reverse strandSDAD1CXCL9: 76,001,275–76,007,515, reverse strandCXCL9ART3: 76,011,176–76,114,094, forward strandART3CXCL10: 76,021,118–76,023,518, reverse strandCXCL10CXCL11: 76,033,682–76,050,206, reverse strandCXCL11NUP54: 76,107,562–76,148,509, reverse strandNUP54SCARB2: 76,158,737–76,213,824, reverse strandSCARB2FAM47E: 76,214,040–76,284,296, forward strandFAM47EFAM47E-STBD1: 76,251,721–76,311,129, forward strandFAM47E-STBD1STBD1: 76,306,275–76,314,086, forward strandSTBD1CCDC158: 76,312,997–76,421,868, reverse strandCCDC158SHROOM3: 76,435,158–76,783,253, forward strandSHROOM3Diagram of SCARB2: 12 exons on the reverse strand of chromosome 4Exon 11: 5 known disease-causing sitesExon 8: 4 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 3 known disease-causing sitesExon 1: 1 known disease-causing siteExon 12: 76,158,737–76,161,751, 3,015 basesExon 11: 76,163,225–76,163,383, 159 basesExon 10: 76,166,250–76,166,301, 52 basesExon 9: 76,168,403–76,168,476, 74 basesExon 8: 76,169,867–76,169,985, 119 basesExon 7: 76,174,144–76,174,313, 170 basesExon 6: 76,175,791–76,175,910, 120 basesExon 5: 76,176,437–76,176,528, 92 basesExon 4: 76,179,517–76,179,705, 189 basesExon 3: 76,180,954–76,181,101, 148 basesExon 2: 76,195,707–76,195,864, 158 basesExon 1: 76,213,427–76,213,824, 398 bases1210864215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 4.7 kb of the gene's 55.1 kb; 1,437 of those bases code for the protein.

    How a genome test reads SCARB2

    30

    positions in SCARB2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 55.1 kb of SCARB2, introns included, not only the 4.7 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). SCARB2 gene: scavenger receptor class B member 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/scarb2

    Vancouver

    Dante Labs. SCARB2 gene: scavenger receptor class B member 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/scarb2

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