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Gene

VCL

vinculin

Summary

Cytogenetic location
10q22.2
Coordinates
Chromosome 10: 73,998,116–74,120,169 (GRCh38)
Exons
22 exons across 122.1 kb
Protein
1,134 amino acids
Also known as
VINC
MANE Select transcript
ENST00000211998.10NM_014000.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Dilated Cardiomyopathy

    • Enlargement and weakening of the left ventricle not explained by coronary artery or valve disease; inherited forms involve TTN, LMNA, RBM20, FLNC, BAG3, DSP, MYH7, TNNT2, DES, PLN and many other genes, and include Barth syndrome and the Emery-Dreifuss muscular dystrophies.

      • ClinGen rates the link strong
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing a genetic cause supports earlier heart monitoring and family screening, and for genes with a high arrhythmia risk such as LMNA, FLNC and RBM20 it informs decisions about rhythm monitoring and implantable defibrillators.

How VCL is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where VCL sits. VCL and 14 genes near it on chromosome 10, from 73,559,143 to 74,559,142.Chromosome 1010q22.2p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.373.6 Mb73.8 Mb74 Mb74.2 Mb74.4 MbUSP54: 73,497,538–73,626,117, reverse strandUSP54MYOZ1: 73,631,556–73,642,103, reverse strandMYOZ1SYNPO2L: 73,644,881–73,663,803, reverse strandSYNPO2LAGAP5: 73,674,276–73,698,109, reverse strandAGAP5SEC24C: 73,744,348–73,772,173, forward strandSEC24CPOFUT4: 73,772,271–73,780,251, forward strandCHCHD1: 73,782,039–73,783,652, forward strandZSWIM8: 73,785,549–73,801,797, forward strandZSWIM8: 73,796,514–73,811,651, reverse strandNDST2: 73,801,740–73,811,963, reverse strandNDST2CAMK2G: 73,812,501–73,874,641, reverse strandCAMK2GPLAU: 73,909,177–73,917,501, forward strandPLAUVCL: 73,998,116–74,120,169, forward strandVCLAP3M1: 74,120,118–74,151,055, reverse strandAP3M1ADK: 74,151,185–74,709,963, forward strandADKDiagram of VCL: 22 exons on the forward strand of chromosome 10Exon 5: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 1: 73,998,116–73,998,375, 260 basesExon 2: 74,043,083–74,043,153, 71 basesExon 3: 74,070,670–74,070,820, 151 basesExon 4: 74,070,975–74,071,083, 109 basesExon 5: 74,072,730–74,072,852, 123 basesExon 6: 74,074,743–74,074,903, 161 basesExon 7: 74,082,454–74,082,544, 91 basesExon 8: 74,083,366–74,083,513, 148 basesExon 9: 74,089,196–74,089,349, 154 basesExon 10: 74,090,023–74,090,198, 176 basesExon 11: 74,094,271–74,094,461, 191 basesExon 12: 74,095,656–74,095,855, 200 basesExon 13: 74,097,204–74,097,332, 129 basesExon 14: 74,100,948–74,101,097, 150 basesExon 15: 74,103,820–74,103,928, 109 basesExon 16: 74,105,051–74,105,353, 303 basesExon 17: 74,107,230–74,107,354, 125 basesExon 18: 74,108,971–74,109,156, 186 basesExon 19: 74,111,909–74,112,112, 204 basesExon 20: 74,114,184–74,114,387, 204 basesExon 21: 74,114,795–74,114,899, 105 basesExon 22: 74,118,023–74,120,169, 2,147 bases12468101214161820225′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.5 kb of the gene's 122.1 kb; 3,405 of those bases code for the protein.

How a genome test reads VCL

7

positions in VCL where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 122.1 kb of VCL, introns included, not only the 5.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). VCL gene: vinculin. Retrieved 17 October 2026, from https://dantelabs.com/genes/vcl

Vancouver

Dante Labs. VCL gene: vinculin [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/vcl

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