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Gene

CD55

CD55 molecule (Cromer blood group)

Summary

Cytogenetic location
1q32.2
Coordinates
Chromosome 1: 207,321,678–207,360,966 (GRCh38)
Exons
10 exons across 39.3 kb
Protein
381 amino acids
Inheritance
Autosomal recessive
Also known as
CR, TC, CROM
Previous symbols
DAF
MANE Select transcript
ENST00000367064.9NM_000574.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • CHAPLE Disease (CD55 Deficiency)

    • CHAPLE disease (CD55-deficient protein-losing enteropathy)Autosomal recessive

      Complement hyperactivation, angiopathic thrombosis and protein-losing enteropathy caused by loss of CD55.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Complement-blocking treatment, including pozelimab, which the FDA approved for this condition in 2023, can control the disease.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How CD55 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where CD55 sits. CD55 and 15 genes near it on chromosome 1, from 206,841,322 to 207,841,321.Chromosome 11q32.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44207 Mb207.2 Mb207.4 Mb207.6 Mb207.8 MbIL19: 206,770,764–206,842,981, forward strandIL19IL20: 206,865,621–206,869,223, forward strandIL20IL24: 206,897,443–206,904,139, forward strandIL24FCMR: 206,903,267–206,923,247, reverse strandFCMRPIGR: 206,928,522–206,949,367, reverse strandPIGRFCAMR: 206,957,965–206,970,625, reverse strandFCAMRC1orf116: 207,018,050–207,032,821, reverse strandC1orf116PFKFB2: 207,034,366–207,081,243, forward strandPFKFB2YOD1: 207,043,849–207,052,980, reverse strandYOD1C4BPB: 207,088,802–207,100,001, forward strandC4BPBC4BPA: 207,102,319–207,145,047, forward strandC4BPACD55: 207,321,678–207,360,966, forward strandCD55CR2: 207,453,024–207,489,895, forward strandCR2CR1: 207,496,147–207,641,776, forward strandCR1CR1L: 207,645,113–207,738,416, forward strandCR1LCD46: 207,752,037–207,795,516, forward strandCD46Diagram of CD55: 10 exons on the forward strand of chromosome 1Exon 1: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 1: 207,321,678–207,321,865, 188 basesExon 2: 207,322,382–207,322,567, 186 basesExon 3: 207,324,559–207,324,750, 192 basesExon 4: 207,325,622–207,325,721, 100 basesExon 5: 207,326,752–207,326,837, 86 basesExon 6: 207,331,108–207,331,296, 189 basesExon 7: 207,336,693–207,336,818, 126 basesExon 8: 207,337,329–207,337,409, 81 basesExon 9: 207,339,397–207,339,417, 21 basesExon 10: 207,359,546–207,360,966, 1,421 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.6 kb of the gene's 39.3 kb; 1,146 of those bases code for the protein.

How a genome test reads CD55

6

positions in CD55 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 39.3 kb of CD55, introns included, not only the 2.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CD55 gene: CD55 molecule (Cromer blood group). Retrieved 17 October 2026, from https://dantelabs.com/genes/cd55

Vancouver

Dante Labs. CD55 gene: CD55 molecule (Cromer blood group) [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cd55

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