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Gene

NUP133

nucleoporin 133

Summary

Cytogenetic location
1q42.13
Coordinates
Chromosome 1: 229,440,259–229,508,341 (GRCh38)
Exons
26 exons across 68.1 kb
Protein
1,156 amino acids
Also known as
FLJ10814
MANE Select transcript
ENST00000261396.6NM_018230.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Nephrotic Syndrome

    • Nephrosis

      Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong

How NUP133 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where NUP133 sits. NUP133 and 6 genes near it on chromosome 1, from 228,974,300 to 229,974,299.Chromosome 11q42.13p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44229 Mb229.2 Mb229.4 Mb229.6 Mb229.8 MbRAB4A: 229,271,062–229,307,213, forward strandRAB4ACCSAP: 229,321,011–229,343,294, reverse strandCCSAPACTA1: 229,430,365–229,434,789, reverse strandACTA1NUP133: 229,440,259–229,508,341, reverse strandNUP133ABCB10: 229,516,582–229,559,034, reverse strandABCB10TAF5L: 229,593,111–229,626,134, reverse strandTAF5LURB2: 229,625,855–229,661,709, forward strandURB2Diagram of NUP133: 26 exons on the reverse strand of chromosome 1Exon 23: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 26: 229,440,259–229,442,040, 1,782 basesExon 25: 229,444,914–229,445,002, 89 basesExon 24: 229,449,126–229,449,190, 65 basesExon 23: 229,450,525–229,450,605, 81 basesExon 22: 229,452,525–229,452,643, 119 basesExon 21: 229,458,161–229,458,296, 136 basesExon 20: 229,460,611–229,460,769, 159 basesExon 19: 229,463,543–229,463,676, 134 basesExon 18: 229,464,624–229,464,875, 252 basesExon 17: 229,465,420–229,465,519, 100 basesExon 16: 229,466,634–229,466,756, 123 basesExon 15: 229,470,580–229,470,804, 225 basesExon 14: 229,475,638–229,475,732, 95 basesExon 13: 229,477,597–229,477,760, 164 basesExon 12: 229,484,054–229,484,145, 92 basesExon 11: 229,486,371–229,486,528, 158 basesExon 10: 229,487,466–229,487,613, 148 basesExon 9: 229,489,955–229,490,102, 148 basesExon 8: 229,495,495–229,495,565, 71 basesExon 7: 229,495,892–229,496,047, 156 basesExon 6: 229,498,136–229,498,306, 171 basesExon 5: 229,499,684–229,499,818, 135 basesExon 4: 229,500,756–229,500,863, 108 basesExon 3: 229,501,999–229,502,102, 104 basesExon 2: 229,506,040–229,506,158, 119 basesExon 1: 229,508,068–229,508,341, 274 bases262422201816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.2 kb of the gene's 68.1 kb; 3,471 of those bases code for the protein.

How a genome test reads NUP133

5

positions in NUP133 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 68.1 kb of NUP133, introns included, not only the 5.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NUP133 gene: nucleoporin 133. Retrieved 17 October 2026, from https://dantelabs.com/genes/nup133

Vancouver

Dante Labs. NUP133 gene: nucleoporin 133 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nup133

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