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Gene

MAGEL2

MAGE family member L2

Summary

Cytogenetic location
15q11.2
Coordinates
Chromosome 15: 23,643,549–23,647,867 (GRCh38)
Exons
1 exon across 4.3 kb
Protein
1,249 amino acids
Also known as
nM15
Previous symbols
NDNL1
MANE Select transcript
ENST00000650528.1NM_019066.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

  • Imprinting Disorders: Prader-Willi, Silver-Russell and Beckwith-Wiedemann

    • Prader-Willi syndrome

      A condition caused by loss of the paternally inherited 15q11-q13 region, causing low muscle tone and feeding difficulties in infancy followed by excessive appetite, obesity, short stature, hypogonadism and learning difficulties.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Early diagnosis allows growth hormone treatment, dietary management and hormone monitoring.

How MAGEL2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 15, with a bracket where MAGEL2 sits. MAGEL2 and 5 genes near it on chromosome 15, from 23,145,708 to 24,145,707.Chromosome 1515q11.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.323.2 Mb23.4 Mb23.6 Mb23.8 Mb24 MbGOLGA6L26: 23,324,535–23,334,196, reverse strandGOLGA6L26GOLGA8S: 23,354,748–23,368,341, forward strandGOLGA8SGOLGA6L2: 23,439,038–23,447,245, reverse strandGOLGA6L2MKRN3: 23,565,674–23,630,075, forward strandMKRN3MAGEL2: 23,643,549–23,647,867, reverse strandMAGEL2NDN: 23,685,400–23,687,305, reverse strandNDNDiagram of MAGEL2: one exon on the reverse strand of chromosome 15Exon 1: 56 known disease-causing sitesExon 1: 23,643,549–23,647,867, 4,319 bases15′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.3 kb of the gene's 4.3 kb; 3,750 of those bases code for the protein.

How a genome test reads MAGEL2

56

positions in MAGEL2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 4.3 kb of MAGEL2, introns included, not only the 4.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MAGEL2 gene: MAGE family member L2. Retrieved 17 October 2026, from https://dantelabs.com/genes/magel2

Vancouver

Dante Labs. MAGEL2 gene: MAGE family member L2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/magel2

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