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Gene

USP8

ubiquitin specific peptidase 8

Summary

Cytogenetic location
15q21.2
Coordinates
Chromosome 15: 50,424,405–50,514,421 (GRCh38)
Exons
20 exons across 90 kb
Protein
1,118 amino acids
Also known as
HumORF8, KIAA0055, UBPY, SPG59
MANE Select transcript
ENST00000307179.9NM_005154.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads USP8 yet. The test sequences your whole genome, so your data includes it all the same.

How USP8 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 15, with a bracket where USP8 sits. USP8 and 9 genes near it on chromosome 15, from 49,969,413 to 50,969,412.Chromosome 1515q21.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.350 Mb50.2 Mb50.4 Mb50.6 Mb50.8 MbATP8B4: 49,858,238–50,182,947, reverse strandATP8B4SLC27A2: 50,182,196–50,236,450, forward strandSLC27A2HDC: 50,241,947–50,265,965, reverse strandHDCGABPB1: 50,275,389–50,355,440, reverse strandGABPB1USP8: 50,424,405–50,514,421, forward strandUSP8USP50: 50,494,018–50,546,708, reverse strandUSP50TRPM7: 50,552,473–50,686,845, reverse strandTRPM7: 50,648,802–50,686,717, reverse strandSPPL2A: 50,702,266–50,765,948, reverse strandSPPL2AAP4E1: 50,908,668–51,005,899, forward strandAP4E1Diagram of USP8: 20 exons on the forward strand of chromosome 15Exon 1: 50,424,405–50,424,514, 110 basesExon 2: 50,439,009–50,439,177, 169 basesExon 3: 50,441,349–50,441,493, 145 basesExon 4: 50,449,400–50,449,485, 86 basesExon 5: 50,459,000–50,459,162, 163 basesExon 6: 50,462,280–50,462,322, 43 basesExon 7: 50,465,047–50,465,191, 145 basesExon 8: 50,471,633–50,471,795, 163 basesExon 9: 50,476,849–50,476,993, 145 basesExon 10: 50,477,276–50,477,499, 224 basesExon 11: 50,481,481–50,482,065, 585 basesExon 12: 50,484,275–50,484,361, 87 basesExon 13: 50,489,801–50,489,881, 81 basesExon 14: 50,490,263–50,490,525, 263 basesExon 15: 50,492,701–50,492,913, 213 basesExon 16: 50,494,070–50,494,280, 211 basesExon 17: 50,495,848–50,496,084, 237 basesExon 18: 50,497,089–50,497,231, 143 basesExon 19: 50,498,596–50,498,728, 133 basesExon 20: 50,498,903–50,514,421, 15,519 bases124681012141618205′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 18.9 kb of the gene's 90 kb; 3,357 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). USP8 gene: ubiquitin specific peptidase 8. Retrieved 16 October 2026, from https://dantelabs.com/genes/usp8

Vancouver

Dante Labs. USP8 gene: ubiquitin specific peptidase 8 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/usp8

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