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Gene

EMP2

epithelial membrane protein 2

Summary

Cytogenetic location
16p13.13
Coordinates
Chromosome 16: 10,528,422–10,580,598 (GRCh38)
Exons
5 exons across 52.2 kb
Protein
167 amino acids
Also known as
XMP
MANE Select transcript
ENST00000359543.8NM_001424.6
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Nephrotic Syndrome

    • Nephrosis

      Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.

      • 1 GenCC submitter rates it definitive or strong

How EMP2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where EMP2 sits. EMP2 and 8 genes near it on chromosome 16, from 10,054,510 to 11,054,509.Chromosome 1616p13.13p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.310.2 Mb10.4 Mb10.6 Mb10.8 Mb11 MbGRIN2A: 9,753,404–10,183,495, reverse strandGRIN2AATF7IP2: 10,326,434–10,483,640, forward strandATF7IP2EMP2: 10,528,422–10,580,598, reverse strandEMP2TEKT5: 10,627,501–10,694,930, reverse strandTEKT5NUBP1: 10,743,786–10,769,812, forward strandNUBP1TVP23A: 10,760,919–10,818,794, reverse strandTVP23ACIITA: 10,866,222–10,943,021, forward strandCIITADEXI: 10,928,891–10,942,481, reverse strandDEXICLEC16A: 10,944,508–11,189,745, forward strandCLEC16ADiagram of EMP2: 5 exons on the reverse strand of chromosome 16Exon 3: 1 known disease-causing siteExon 5: 10,528,422–10,533,092, 4,671 basesExon 4: 10,537,928–10,538,074, 147 basesExon 3: 10,543,570–10,543,660, 91 basesExon 2: 10,547,540–10,547,677, 138 basesExon 1: 10,580,549–10,580,598, 50 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.1 kb of the gene's 52.2 kb; 504 of those bases code for the protein.

Sequencing EMP2

2Low

How hard EMP2 is to sequence with short reads, out of 100

  • Mappability0.6%
  • Homology0%
  • Repeats5.7%
  • GC content6.7%
  • Reference coverage0%

2

positions in EMP2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 52.2 kb of EMP2, introns included, not only the 5.1 kb of exons.

Genes linked to the same conditions

Traits linked to EMP2

The Human Phenotype Ontology lists these as features of the rare conditions EMP2 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). EMP2 gene: epithelial membrane protein 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/emp2

Vancouver

Dante Labs. EMP2 gene: epithelial membrane protein 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/emp2

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