Trait
Angioedema
Rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues of the skin of the face, normally around the mouth, and the mucosa of the mouth and/or throat, as well as the tongue during a period of minutes to several hours. The swelling can also occur elsewhere, typically in the hands. Angioedema is similar to urticaria, but the swelling is subcutaneous rather than on the epidermis.
Summary
- Also called
- Angioneurotic edema, Angioneurotic oedema, Angiooedema, Quincke edema, Quincke oedema
Reference genomeGRCh38hg38
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Get my Genome Test13 genes linked to Angioedema
Changes in these genes cause rare conditions in which Angioedema is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ANGPT1angiopoietin 1 | Always | In 1 condition |
| KNG1kininogen 1 | Always | In 1 condition |
| MYOFmyoferlin | Always | In 1 condition |
| XPNPEP2X-prolyl aminopeptidase 2 | Always | In 2 conditions |
| DNASE1L3deoxyribonuclease 1L3 | Often (30–79%) | In 1 condition |
| PLCG2phospholipase C gamma 2 | Often (30–79%) | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Sometimes (5–29%) | In 2 conditions |
| KITKIT proto-oncogene, receptor tyrosine kinase | Rarely (1–4%) | In 1 condition |
| CPN1carboxypeptidase N subunit 1 | Not recorded | In 1 condition |
| F12coagulation factor XII | Not recorded | In 1 condition |
| HS3ST6heparan sulfate-glucosamine 3-sulfotransferase 6 | Not recorded | In 1 condition |
| PLGplasminogen | Not recorded | In 1 condition |
| SERPING1serpin family G member 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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