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Gene

NEXN

nexilin F-actin binding protein

Summary

Cytogenetic location
1p31.1
Coordinates
Chromosome 1: 77,888,624–77,943,895 (GRCh38)
Exons
13 exons across 55.3 kb
Protein
675 amino acids
Also known as
nexilin, NELIN
MANE Select transcript
ENST00000334785.12NM_144573.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Dilated Cardiomyopathy

    • Enlargement and weakening of the left ventricle not explained by coronary artery or valve disease; inherited forms involve TTN, LMNA, RBM20, FLNC, BAG3, DSP, MYH7, TNNT2, DES, PLN and many other genes, and include Barth syndrome and the Emery-Dreifuss muscular dystrophies.

      • ClinGen rates the link strong
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing a genetic cause supports earlier heart monitoring and family screening, and for genes with a high arrhythmia risk such as LMNA, FLNC and RBM20 it informs decisions about rhythm monitoring and implantable defibrillators.

How NEXN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where NEXN sits. NEXN and 8 genes near it on chromosome 1, from 77,416,260 to 78,416,259.Chromosome 11p31.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4477.6 Mb77.8 Mb78 Mb78.2 Mb78.4 MbAK5: 77,281,853–77,559,966, forward strandAK5ZZZ3: 77,562,416–77,683,550, reverse strandZZZ3USP33: 77,694,724–77,759,904, reverse strandUSP33MIGA1: 77,779,619–77,879,595, forward strandMIGA1NEXN: 77,888,624–77,943,895, forward strandNEXNFUBP1: 77,944,055–77,979,527, reverse strandFUBP1DNAJB4: 77,979,070–78,019,864, forward strandDNAJB4GIPC2: 77,979,542–78,138,463, forward strandGIPC2PTGFR: 78,303,884–78,540,701, forward strandPTGFRDiagram of NEXN: 13 exons on the forward strand of chromosome 1Exon 3: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 8: 6 known disease-causing sitesExon 9: 3 known disease-causing sitesExon 10: 7 known disease-causing sitesExon 11: 4 known disease-causing sitesExon 12: 3 known disease-causing sitesExon 1: 77,888,624–77,888,759, 136 basesExon 2: 77,916,055–77,916,133, 79 basesExon 3: 77,917,566–77,917,757, 192 basesExon 4: 77,917,960–77,918,038, 79 basesExon 5: 77,918,125–77,918,273, 149 basesExon 6: 77,925,188–77,925,229, 42 basesExon 7: 77,926,414–77,926,611, 198 basesExon 8: 77,926,716–77,926,892, 177 basesExon 9: 77,929,316–77,929,504, 189 basesExon 10: 77,933,282–77,933,479, 198 basesExon 11: 77,935,823–77,936,044, 222 basesExon 12: 77,942,023–77,942,208, 186 basesExon 13: 77,942,461–77,943,895, 1,435 bases1510135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.3 kb of the gene's 55.3 kb; 2,028 of those bases code for the protein.

How a genome test reads NEXN

39

positions in NEXN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 55.3 kb of NEXN, introns included, not only the 3.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NEXN gene: nexilin F-actin binding protein. Retrieved 17 October 2026, from https://dantelabs.com/genes/nexn

Vancouver

Dante Labs. NEXN gene: nexilin F-actin binding protein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nexn

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