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Gene

INF2

inverted formin 2

Summary

Cytogenetic location
14q32.33
Coordinates
Chromosome 14: 104,689,618–104,722,535 (GRCh38)
Exons
23 exons across 32.9 kb
Protein
1,249 amino acids
Also known as
MGC13251
Previous symbols
C14orf151, C14orf173
MANE Select transcript
ENST00000392634.9NM_022489.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Focal Segmental Glomerulosclerosis

    • A renal disorder characterized by sclerotic lesions in the glomeruli. Causes include drugs, viruses, and malignancies (lymphomas), or it may be idiopathic. It presents with asymptomatic proteinuria or nephritic syndrome and it may lead to renal failure.

      • 2 GenCC submitters rate it definitive or strong

  • Glomerulosclerosis

    • A hardening of the kidney glomerulus caused by scarring of the blood vessels.

      • 2 GenCC submitters rate it definitive or strong

Broader groupings

  • Charcot-Marie-Tooth Disease

    • One of 62 genes linked to it

      A group of inherited peripheral neuropathies causing progressive weakness and wasting of the distal muscles and loss of sensation, mainly in the feet and hands.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Genetic counseling, subtype-specific monitoring, physical therapy, orthotics, neurotoxic drug avoidance, gene-specific clinical trials, surveillance for associated features

How INF2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where INF2 sits. INF2 and 14 genes near it on chromosome 14, from 104,206,077 to 105,206,076.Chromosome 1414q32.33p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.33104.4 Mb104.6 Mb104.8 Mb105 Mb105.2 MbTMEM179: 104,474,678–104,605,647, reverse strandTMEM179C14orf180: 104,579,550–104,590,515, forward strandC14orf180INF2: 104,689,618–104,722,535, forward strandINF2ADSS1: 104,724,174–104,747,523, forward strandADSS1SIVA1: 104,753,122–104,768,494, forward strandSIVA1AKT1: 104,769,348–104,799,934, reverse strandAKT1ZBTB42: 104,799,415–104,804,712, forward strandZBTB42CEP170B: 104,864,498–104,896,770, forward strandCEP170BPLD4: 104,924,713–104,937,784, forward strandPLD4AHNAK2: 104,937,244–104,978,374, reverse strandAHNAK2CLBA1: 104,985,758–105,010,482, forward strandCLBA1CDCA4: 105,008,532–105,033,828, reverse strandCDCA4GPR132: 105,048,658–105,065,940, reverse strandGPR132JAG2: 105,140,982–105,168,919, reverse strandJAG2NUDT14: 105,172,937–105,181,323, reverse strandNUDT14Diagram of INF2: 23 exons on the forward strand of chromosome 14Exon 2: 20 known disease-causing sitesExon 3: 6 known disease-causing sitesExon 4: 10 known disease-causing sitesExon 6: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 1: 104,689,618–104,689,739, 122 basesExon 2: 104,701,357–104,701,756, 400 basesExon 3: 104,703,105–104,703,220, 116 basesExon 4: 104,703,295–104,703,454, 160 basesExon 5: 104,703,916–104,703,949, 34 basesExon 6: 104,706,035–104,706,176, 142 basesExon 7: 104,706,910–104,707,051, 142 basesExon 8: 104,707,253–104,708,002, 750 basesExon 9: 104,708,436–104,708,587, 152 basesExon 10: 104,708,671–104,708,732, 62 basesExon 11: 104,709,281–104,709,383, 103 basesExon 12: 104,709,620–104,709,705, 86 basesExon 13: 104,710,088–104,710,188, 101 basesExon 14: 104,710,937–104,711,007, 71 basesExon 15: 104,711,079–104,711,186, 108 basesExon 16: 104,711,629–104,711,699, 71 basesExon 17: 104,712,433–104,712,553, 121 basesExon 18: 104,712,828–104,712,992, 165 basesExon 19: 104,713,207–104,713,309, 103 basesExon 20: 104,713,445–104,713,606, 162 basesExon 21: 104,714,203–104,714,856, 654 basesExon 22: 104,715,284–104,715,340, 57 basesExon 23: 104,718,795–104,722,535, 3,741 bases15101520235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.6 kb of the gene's 32.9 kb; 3,750 of those bases code for the protein.

How a genome test reads INF2

39

positions in INF2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 32.9 kb of INF2, introns included, not only the 7.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). INF2 gene: inverted formin 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/inf2

Vancouver

Dante Labs. INF2 gene: inverted formin 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/inf2

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