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Gene

CRYAB

crystallin alpha B

Summary

Cytogenetic location
11q23.1
Coordinates
Chromosome 11: 111,908,564–111,911,770 (GRCh38)
Exons
3 exons across 3.2 kb
Protein
175 amino acids
Also known as
HSPB5
Previous symbols
CRYA2
MANE Select transcript
ENST00000650687.2NM_001289808.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Distal Myopathies

    • Distal myopathy

      A group of inherited muscle disorders in which weakness starts in the hands, forearms, lower legs or feet, caused by genes such as TTN, DYSF, FLNC, MYH7, ADSS1, SMPX and MATR3.

      • 2 GenCC submitters rate it definitive or strong

  • Hereditary Congenital & Juvenile Cataract

    • Early-Onset Non-Syndromic Cataract

      Cataract that appears at birth or early in life without other features, caused by changes in lens genes such as the crystallins (CRYAA, CRYBB2, CRYGD and others), GJA3, GJA8 and MIP.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Early detection and surgery in children help prevent permanent vision loss from amblyopia, and family members can be offered eye checks.

  • Myofibrillar Myopathies

    • Myofibrillar myopathy

      A group of muscle disorders in which the contractile structure of muscle fibers breaks down, caused by genes such as DES, CRYAB, MYOT, LDB3, FLNC and BAG3.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Because the heart is often involved, regular heart checks (such as ECG and echocardiography) are recommended even without symptoms.

How CRYAB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 11, with a bracket where CRYAB sits. CRYAB and 25 genes near it on chromosome 11, from 111,410,167 to 112,410,166.Chromosome 1111q23.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25111.6 Mb111.8 Mb112 Mb112.2 Mb112.4 MbPOU2AF1: 111,352,255–111,455,630, reverse strandPOU2AF1BTG4: 111,467,526–111,514,367, reverse strandBTG4HOATZ: 111,514,763–111,537,043, forward strandHOATZLAYN: 111,540,280–111,565,625, forward strandLAYNSIK2: 111,602,383–111,730,855, forward strandSIK2PPP2R1B: 111,726,908–111,766,713, reverse strandPPP2R1BALG9: 111,782,195–111,872,405, reverse strand: 111,786,286–111,879,425, reverse strandFDXACB1: 111,873,947–111,881,243, reverse strandCFAP68: 111,878,935–111,885,975, forward strandCRYAB: 111,908,564–111,911,770, reverse strandCRYABHSPB2: 111,912,159–111,915,098, forward strandHSPB2HSPB2-C11orf52: 111,912,736–111,926,871, forward strandHSPB2-C11orf52C11orf52: 111,918,032–111,926,873, forward strandC11orf52DIXDC1: 111,927,144–112,023,091, forward strandDLAT: 112,025,033–112,064,404, forward strandDLATPIH1D2: 112,052,485–112,074,274, reverse strandPIH1D2NKAPD1: 112,074,086–112,085,152, forward strandNKAPD1TIMM8B: 112,082,730–112,086,799, reverse strandTIMM8BSDHD: 112,086,361–112,120,016, forward strandSDHD: 112,086,903–112,193,805, forward strandIL18: 112,142,701–112,164,391, reverse strandIL18TEX12: 112,167,313–112,173,057, forward strandTEX12BCO2: 112,175,472–112,225,895, forward strandBCO2PTS: 112,226,059–112,270,449, forward strandPTSPLET1: 112,248,153–112,260,860, reverse strandPLET1Diagram of CRYAB: 3 exons on the reverse strand of chromosome 11Exon 3: 4 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 8 known disease-causing sitesExon 3: 111,908,564–111,908,967, 404 basesExon 2: 111,910,327–111,910,449, 123 basesExon 1: 111,911,524–111,911,770, 247 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.8 kb of the gene's 3.2 kb; 528 of those bases code for the protein.

How a genome test reads CRYAB

13

positions in CRYAB where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.2 kb of CRYAB, introns included, not only the 0.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CRYAB gene: crystallin alpha B. Retrieved 16 October 2026, from https://dantelabs.com/genes/cryab

Vancouver

Dante Labs. CRYAB gene: crystallin alpha B [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cryab

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