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Gene

CRB2

crumbs cell polarity complex component 2

Summary

Cytogenetic location
9q33.3
Coordinates
Chromosome 9: 123,356,197–123,378,753 (GRCh38)
Exons
13 exons across 22.6 kb
Protein
1,285 amino acids
Also known as
FLJ38464, FLJ16786
MANE Select transcript
ENST00000373631.8NM_173689.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Focal Segmental Glomerulosclerosis

    • A renal disorder characterized by sclerotic lesions in the glomeruli. Causes include drugs, viruses, and malignancies (lymphomas), or it may be idiopathic. It presents with asymptomatic proteinuria or nephritic syndrome and it may lead to renal failure.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong

  • Glomerulosclerosis

    • A hardening of the kidney glomerulus caused by scarring of the blood vessels.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong

How CRB2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 9, with a bracket where CRB2 sits. CRB2 and 7 genes near it on chromosome 9, from 122,867,475 to 123,867,474.Chromosome 99q33.3p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.3123 Mb123.2 Mb123.4 Mb123.6 Mb123.8 MbRC3H2: 122,844,556–122,905,513, reverse strandRC3H2ZBTB6: 122,908,053–122,913,333, reverse strandZBTB6ZBTB26: 122,915,548–122,931,565, reverse strandZBTB26RABGAP1: 122,940,833–123,163,067, forward strandRABGAP1GPR21: 123,033,650–123,038,690, forward strandGPR21STRBP: 123,109,494–123,269,102, reverse strandSTRBPCRB2: 123,356,197–123,378,753, forward strandCRB2DENND1A: 123,379,648–123,930,154, reverse strandDENND1ADiagram of CRB2: 13 exons on the forward strand of chromosome 9Exon 2: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 7: 3 known disease-causing sitesExon 8: 4 known disease-causing sitesExon 9: 1 known disease-causing siteExon 10: 8 known disease-causing sitesExon 12: 1 known disease-causing siteExon 1: 123,356,197–123,356,354, 158 basesExon 2: 123,362,865–123,363,188, 324 basesExon 3: 123,365,917–123,366,112, 196 basesExon 4: 123,366,227–123,366,366, 140 basesExon 5: 123,367,172–123,367,357, 186 basesExon 6: 123,367,573–123,367,686, 114 basesExon 7: 123,370,108–123,370,980, 873 basesExon 8: 123,371,070–123,371,578, 509 basesExon 9: 123,372,177–123,372,342, 166 basesExon 10: 123,373,134–123,373,920, 787 basesExon 11: 123,374,579–123,374,695, 117 basesExon 12: 123,375,217–123,375,343, 127 basesExon 13: 123,376,838–123,378,753, 1,916 bases124681012135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.6 kb of the gene's 22.6 kb; 3,858 of those bases code for the protein.

How a genome test reads CRB2

23

positions in CRB2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 22.6 kb of CRB2, introns included, not only the 5.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CRB2 gene: crumbs cell polarity complex component 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/crb2

Vancouver

Dante Labs. CRB2 gene: crumbs cell polarity complex component 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/crb2

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