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Gene

LAMA3

laminin subunit alpha 3

Summary

Cytogenetic location
18q11.2
Coordinates
Chromosome 18: 23,689,453–23,955,066 (GRCh38)
Exons
75 exons across 265.6 kb
Protein
3,333 amino acids
Inheritance
Autosomal recessive
Also known as
nicein-150kDa, kalinin-165kDa, BM600-150kDa, epiligrin
Previous symbols
LAMNA
MANE Select transcript
ENST00000313654.14NM_198129.4
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Epidermolysis Bullosa

    • Epidermolysis Bullosa, Junctional 2a, IntermediateAutosomal recessive
      • 1 GenCC submitter rates it definitive or strong
    • Epidermolysis Bullosa, Junctional 2b, SevereAutosomal recessive
      • 1 GenCC submitter rates it definitive or strong
    • Inherited epidermolysis bullosa

      All inherited forms of skin fragility with blistering, including simplex, junctional and dystrophic epidermolysis bullosa and Kindler syndrome.

      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Recessive dystrophic forms need regular skin cancer surveillance, and gene-based wound therapy is now available for dystrophic EB.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How LAMA3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 18, with a bracket where LAMA3 sits. LAMA3 and 8 genes near it on chromosome 18, from 23,322,260 to 24,322,259.Chromosome 1818q11.2p11.32p11.31p11.23p11.22p11.21p11.1q11.1q11.2q12.1q12.2q12.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q2323.4 Mb23.6 Mb23.8 Mb24 Mb24.2 MbSLC35D4: 23,197,144–23,437,976, reverse strandSLC35D4RIOK3: 23,453,265–23,486,603, forward strandRIOK3RMC1: 23,503,460–23,533,181, forward strandRMC1NPC1: 23,506,184–23,586,969, reverse strandNPC1ANKRD29: 23,598,926–23,663,558, reverse strandANKRD29LAMA3: 23,689,453–23,955,066, forward strandLAMA3TTC39C: 23,992,773–24,135,970, forward strandTTC39CCABYR: 24,138,961–24,161,603, forward strandCABYROSBPL1A: 24,162,045–24,397,908, reverse strandOSBPL1ADiagram of LAMA3: 75 exons on the forward strand of chromosome 18Exon 17: 1 known disease-causing siteExon 33: 1 known disease-causing siteExon 34: 1 known disease-causing siteExon 35: 1 known disease-causing siteExon 39: 2 known disease-causing sitesExon 40: 3 known disease-causing sitesExon 44: 4 known disease-causing sitesExon 46: 1 known disease-causing siteExon 47: 3 known disease-causing sitesExon 48: 2 known disease-causing sitesExon 49: 2 known disease-causing sitesExon 50: 4 known disease-causing sitesExon 51: 1 known disease-causing siteExon 53: 1 known disease-causing siteExon 56: 2 known disease-causing sitesExon 57: 1 known disease-causing siteExon 59: 2 known disease-causing sitesExon 60: 1 known disease-causing siteExon 61: 1 known disease-causing siteExon 62: 1 known disease-causing siteExon 63: 3 known disease-causing sitesExon 64: 3 known disease-causing sitesExon 66: 2 known disease-causing sitesExon 67: 2 known disease-causing sitesExon 68: 1 known disease-causing siteExon 69: 1 known disease-causing siteExon 71: 2 known disease-causing sitesExon 72: 3 known disease-causing sitesExon 74: 1 known disease-causing siteExon 75: 1 known disease-causing siteExon 1: 23,689,453–23,689,977, 525 basesExon 2: 23,713,920–23,714,072, 153 basesExon 3: 23,747,943–23,748,060, 118 basesExon 4: 23,749,428–23,749,546, 119 basesExon 5: 23,750,918–23,751,088, 171 basesExon 6: 23,753,721–23,753,812, 92 basesExon 7: 23,758,396–23,758,511, 116 basesExon 8: 23,763,405–23,763,523, 119 basesExon 9: 23,773,497–23,773,587, 91 basesExon 10: 23,775,792–23,775,923, 132 basesExon 11: 23,777,557–23,777,619, 63 basesExon 12: 23,784,023–23,784,157, 135 basesExon 13: 23,810,366–23,810,503, 138 basesExon 14: 23,813,057–23,813,103, 47 basesExon 15: 23,814,403–23,814,502, 100 basesExon 16: 23,815,188–23,815,240, 53 basesExon 17: 23,815,468–23,815,573, 106 basesExon 18: 23,816,388–23,816,487, 100 basesExon 19: 23,819,841–23,819,997, 157 basesExon 20: 23,822,252–23,822,375, 124 basesExon 21: 23,824,423–23,824,565, 143 basesExon 22: 23,826,702–23,826,799, 98 basesExon 23: 23,827,314–23,827,467, 154 basesExon 24: 23,833,828–23,833,988, 161 basesExon 25: 23,836,981–23,837,089, 109 basesExon 26: 23,838,781–23,838,878, 98 basesExon 27: 23,839,785–23,839,929, 145 basesExon 28: 23,842,395–23,842,521, 127 basesExon 29: 23,842,611–23,842,750, 140 basesExon 30: 23,845,009–23,845,124, 116 basesExon 31: 23,846,297–23,846,508, 212 basesExon 32: 23,847,464–23,847,668, 205 basesExon 33: 23,857,844–23,857,988, 145 basesExon 34: 23,858,689–23,858,829, 141 basesExon 35: 23,861,646–23,861,807, 162 basesExon 36: 23,864,785–23,864,883, 99 basesExon 37: 23,867,834–23,867,917, 84 basesExon 38: 23,871,431–23,871,661, 231 basesExon 39: 23,876,294–23,876,407, 114 basesExon 40: 23,881,936–23,882,045, 110 basesExon 41: 23,884,773–23,884,853, 81 basesExon 42: 23,890,011–23,890,117, 107 basesExon 43: 23,894,298–23,894,348, 51 basesExon 44: 23,894,907–23,895,058, 152 basesExon 45: 23,898,738–23,898,848, 111 basesExon 46: 23,898,954–23,899,065, 112 basesExon 47: 23,899,288–23,899,455, 168 basesExon 48: 23,901,127–23,901,323, 197 basesExon 49: 23,903,009–23,903,125, 117 basesExon 50: 23,903,933–23,904,087, 155 basesExon 51: 23,904,553–23,904,694, 142 basesExon 52: 23,905,522–23,905,624, 103 basesExon 53: 23,907,550–23,907,666, 117 basesExon 54: 23,907,756–23,907,935, 180 basesExon 55: 23,909,153–23,909,295, 143 basesExon 56: 23,912,711–23,912,881, 171 basesExon 57: 23,914,410–23,914,561, 152 basesExon 58: 23,914,698–23,914,860, 163 basesExon 59: 23,915,289–23,915,422, 134 basesExon 60: 23,916,551–23,916,695, 145 basesExon 61: 23,920,935–23,921,054, 120 basesExon 62: 23,921,452–23,921,585, 134 basesExon 63: 23,928,123–23,928,240, 118 basesExon 64: 23,928,625–23,928,765, 141 basesExon 65: 23,931,062–23,931,201, 140 basesExon 66: 23,932,160–23,932,291, 132 basesExon 67: 23,933,782–23,933,935, 154 basesExon 68: 23,939,223–23,939,386, 164 basesExon 69: 23,943,788–23,943,971, 184 basesExon 70: 23,946,144–23,946,284, 141 basesExon 71: 23,949,765–23,949,924, 160 basesExon 72: 23,950,029–23,950,159, 131 basesExon 73: 23,951,684–23,951,777, 94 basesExon 74: 23,952,990–23,953,109, 120 basesExon 75: 23,954,503–23,955,066, 564 bases110203040506070755′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.7 kb of the gene's 265.6 kb; 10,002 of those bases code for the protein.

How a genome test reads LAMA3

88

positions in LAMA3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 265.6 kb of LAMA3, introns included, not only the 10.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LAMA3 gene: laminin subunit alpha 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/lama3

Vancouver

Dante Labs. LAMA3 gene: laminin subunit alpha 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lama3

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