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Gene

SGCD

sarcoglycan delta

Summary

Cytogenetic location
5q33.2-q33.3
Coordinates
Chromosome 5: 156,327,164–156,767,788 (GRCh38)
Exons
9 exons across 440.6 kb
Protein
290 amino acids
Also known as
DAGD, LGMD2F, CMD1L
MANE Select transcript
ENST00000337851.9NM_000337.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

  • Dilated Cardiomyopathy

    • Enlargement and weakening of the left ventricle not explained by coronary artery or valve disease; inherited forms involve TTN, LMNA, RBM20, FLNC, BAG3, DSP, MYH7, TNNT2, DES, PLN and many other genes, and include Barth syndrome and the Emery-Dreifuss muscular dystrophies.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing a genetic cause supports earlier heart monitoring and family screening, and for genes with a high arrhythmia risk such as LMNA, FLNC and RBM20 it informs decisions about rhythm monitoring and implantable defibrillators.

  • Limb-Girdle Muscular Dystrophy

    • Limb-girdle Muscular Dystrophy is defined as a collection of numerous subtypes with differing inheritance patterns (with diagnostic sufficiency being varied too). Carriers of variants related to the condition should seek guidance from a muscular-skeletal specialist for a definitive diagnosis.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

How SGCD is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
  • Variants with a page
Chromosome 5, with a bracket where SGCD sits. SGCD and 7 genes near it on chromosome 5, from 155,886,539 to 157,208,413.Chromosome 55q33.2-q33.3p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3156 Mb156.2 Mb156.4 Mb156.6 Mb156.8 Mb157 Mb157.2 MbSGCD: 156,327,164–156,767,788, forward strandSGCDPPP1R2B: 156,850,295–156,852,528, forward strandPPP1R2BTIMD4: 156,918,639–156,963,230, reverse strandTIMD4HAVCR1: 157,025,939–157,069,396, reverse strandHAVCR1HAVCR2: 157,085,422–157,142,869, reverse strandHAVCR2MED7: 157,134,848–157,159,019, reverse strandMED7ITK: 157,142,933–157,255,185, forward strandITKGARIN3: 157,161,846–157,166,264, reverse strandGARIN3Diagram of SGCD: 9 exons on the forward strand of chromosome 5Exon 3: 12 known disease-causing sitesExon 4: 8 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 6: 9 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 8: 3 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 1: 156,327,164–156,327,232, 69 basesExon 2: 156,329,534–156,329,579, 46 basesExon 3: 156,344,489–156,344,677, 189 basesExon 4: 156,508,601–156,508,702, 102 bases. 1 variant with a page in exon 4. List themExon 5: 156,589,231–156,589,318, 88 basesExon 6: 156,594,932–156,595,051, 120 bases. 1 variant with a page in exon 6. List themExon 7: 156,647,464–156,647,536, 73 basesExon 8: 156,757,581–156,757,704, 124 basesExon 9: 156,759,217–156,767,788, 8,572 bases1595′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.4 kb of the gene's 440.6 kb; 873 of those bases code for the protein.

How a genome test reads SGCD

47

positions in SGCD where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 440.6 kb of SGCD, introns included, not only the 9.4 kb of exons.

Variants with a page (2)

The SGCD variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.

VariantHGVS c.Exon or intronPosition (GRCh38)ClinVar classificationReview status
R97Xc.289C>TExon 4156,508,697Pathogenic3 stars out of 4 reviewed by expert panel
R165Xc.493C>TExon 6156,595,042Pathogenic3 stars out of 4 reviewed by expert panel

Genes linked to the same conditions

Traits linked to SGCD

The Human Phenotype Ontology lists these as features of the rare conditions SGCD can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SGCD gene: sarcoglycan delta. Retrieved 17 October 2026, from https://dantelabs.com/genes/sgcd

Vancouver

Dante Labs. SGCD gene: sarcoglycan delta [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/sgcd

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