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Gene

KRT2

keratin 2

Summary

Cytogenetic location
12q13.13
Coordinates
Chromosome 12: 52,644,558–52,652,211 (GRCh38)
Exons
9 exons across 7.7 kb
Protein
639 amino acids
Inheritance
Autosomal recessive
Also known as
KRTE
Previous symbols
KRT2A
MANE Select transcript
ENST00000309680.4NM_000423.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Ichthyoses

    • Autosomal recessive congenital ichthyosisAutosomal recessive

      A group of recessive ichthyoses, including harlequin ichthyosis and lamellar ichthyosis, usually present at birth, often with a collodion membrane.

      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Early diagnosis guides neonatal care, emollient and keratolytic regimens, and heat-intolerance precautions.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How KRT2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 12, with a bracket where KRT2 sits. KRT2 and 31 genes near it on chromosome 12, from 52,148,385 to 53,148,384.Chromosome 1212q13.13p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3352.2 Mb52.4 Mb52.6 Mb52.8 Mb53 MbKRT80: 52,168,996–52,192,311, reverse strandKRT80KRT7: 52,232,520–52,252,186, forward strandKRT7KRT86: 52,249,300–52,309,163, forward strandKRT86KRT81: 52,285,913–52,291,534, reverse strandKRT81KRT83: 52,314,301–52,321,398, reverse strandKRT83KRT85: 52,360,006–52,367,481, reverse strandKRT85KRT84: 52,377,812–52,385,652, reverse strandKRT84KRT82: 52,393,931–52,406,335, reverse strandKRT82KRT75: 52,424,070–52,434,380, reverse strandKRT75KRT6B: 52,446,651–52,452,154, reverse strandKRT6BKRT6C: 52,468,516–52,473,805, reverse strandKRT6CKRT6A: 52,487,176–52,493,265, reverse strandKRT6AKRT5: 52,514,575–52,520,530, reverse strandKRT5KRT71: 52,543,909–52,553,145, reverse strandKRT71KRT74: 52,565,151–52,573,843, reverse strandKRT74KRT72: 52,585,589–52,601,538, reverse strandKRT72KRT73: 52,607,570–52,618,559, reverse strandKRT73KRT2: 52,644,558–52,652,211, reverse strandKRT2KRT1: 52,674,736–52,680,407, reverse strandKRT1KRT77: 52,689,626–52,703,524, reverse strandKRT77KRT76: 52,768,155–52,777,345, reverse strandKRT76KRT3: 52,789,685–52,796,117, reverse strandKRT3KRT4: 52,806,549–52,814,116, reverse strandKRT4KRT79: 52,821,408–52,834,312, reverse strandKRT79KRT78: 52,837,804–52,849,092, reverse strandKRT78KRT8: 52,897,182–52,949,954, reverse strandKRT8KRT18: 52,945,688–52,952,911, forward strandKRT18EIF4B: 53,006,263–53,042,230, forward strandEIF4BTNS2: 53,046,969–53,064,621, forward strandTNS2SPRYD3: 53,064,316–53,079,414, reverse strandSPRYD3IGFBP6: 53,097,436–53,102,345, forward strandIGFBP6SOAT2: 53,103,457–53,124,538, forward strandSOAT2Diagram of KRT2: 9 exons on the reverse strand of chromosome 12Exon 7: 2 known disease-causing sitesExon 1: 2 known disease-causing sitesExon 9: 52,644,558–52,645,434, 877 basesExon 8: 52,645,535–52,645,569, 35 basesExon 7: 52,646,740–52,646,960, 221 basesExon 6: 52,647,730–52,647,855, 126 basesExon 5: 52,648,173–52,648,337, 165 basesExon 4: 52,649,007–52,649,102, 96 basesExon 3: 52,649,914–52,649,974, 61 basesExon 2: 52,650,339–52,650,553, 215 basesExon 1: 52,651,558–52,652,211, 654 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 7.7 kb; 1,920 of those bases code for the protein.

How a genome test reads KRT2

4

positions in KRT2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.7 kb of KRT2, introns included, not only the 2.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KRT2 gene: keratin 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/krt2

Vancouver

Dante Labs. KRT2 gene: keratin 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/krt2

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