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Gene

TCAP

titin-cap

Summary

Cytogenetic location
17q12
Coordinates
Chromosome 17: 39,665,349–39,666,554 (GRCh38)
Exons
2 exons across 1.2 kb
Protein
167 amino acids
Inheritance
Autosomal dominant
Also known as
T-cap, TELE, telethonin, CMD1N
Previous symbols
LGMD2G
MANE Select transcript
ENST00000309889.3NM_003673.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Dilated Cardiomyopathy

    • Enlargement and weakening of the left ventricle not explained by coronary artery or valve disease; inherited forms involve TTN, LMNA, RBM20, FLNC, BAG3, DSP, MYH7, TNNT2, DES, PLN and many other genes, and include Barth syndrome and the Emery-Dreifuss muscular dystrophies.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing a genetic cause supports earlier heart monitoring and family screening, and for genes with a high arrhythmia risk such as LMNA, FLNC and RBM20 it informs decisions about rhythm monitoring and implantable defibrillators.

  • Limb-Girdle Muscular Dystrophy

    • Limb-girdle Muscular Dystrophy is defined as a collection of numerous subtypes with differing inheritance patterns (with diagnostic sufficiency being varied too). Carriers of variants related to the condition should seek guidance from a muscular-skeletal specialist for a definitive diagnosis.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

Broader groupings

  • Hypertrophic Cardiomyopathy

    • Autosomal dominant

      One of 62 genes linked to it

      A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How TCAP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 17, with a bracket where TCAP sits. TCAP and 28 genes near it on chromosome 17, from 39,165,952 to 40,165,951.Chromosome 1717q12p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.339.2 Mb39.4 Mb39.6 Mb39.8 Mb40 MbARL5C: 39,156,894–39,167,484, reverse strandARL5CCACNB1: 39,173,453–39,197,877, reverse strandCACNB1RPL19: 39,200,282–39,204,840, forward strandRPL19STAC2: 39,210,540–39,225,945, reverse strandSTAC2FBXL20: 39,252,663–39,402,523, reverse strandFBXL20MED1: 39,404,253–39,451,306, reverse strandMED1CDK12: 39,461,437–39,567,559, forward strandCDK12NEUROD2: 39,603,536–39,609,777, reverse strandNEUROD2PPP1R1B: 39,626,740–39,636,626, forward strandSTARD3: 39,637,058–39,664,201, forward strandSTARD3TCAP: 39,665,349–39,666,554, forward strandTCAPPNMT: 39,667,981–39,670,484, forward strandPNMTPGAP3: 39,671,120–39,696,797, reverse strandPGAP3ERBB2: 39,687,914–39,730,426, forward strandERBB2MIEN1: 39,728,496–39,730,555, reverse strandMIEN1GRB7: 39,737,490–39,747,292, forward strandGRB7IKZF3: 39,757,715–39,864,368, reverse strandIKZF3ZPBP2: 39,868,202–39,877,896, forward strandZPBP2GSDMB: 39,904,595–39,919,854, reverse strandGSDMBORMDL3: 39,919,927–39,982,186, reverse strandORMDL3LRRC3C: 39,927,725–39,946,538, forward strandLRRC3CGSDMA: 39,953,263–39,977,875, forward strandGSDMAPSMD3: 39,980,800–39,997,960, forward strandPSMD3CSF3: 40,015,361–40,017,816, forward strandCSF3MED24: 40,019,097–40,061,215, reverse strandMED24THRA: 40,058,290–40,093,867, forward strandTHRANR1D1: 40,092,793–40,100,630, reverse strandNR1D1MSL1: 40,121,637–40,136,935, forward strandMSL1CASC3: 40,140,278–40,177,001, forward strandCASC3Diagram of TCAP: 2 exons on the forward strand of chromosome 17Exon 1: 15 known disease-causing sitesExon 2: 9 known disease-causing sitesExon 1: 39,665,349–39,665,469, 121 basesExon 2: 39,665,716–39,666,554, 839 bases125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1 kb of the gene's 1.2 kb; 504 of those bases code for the protein.

How a genome test reads TCAP

27

positions in TCAP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 1.2 kb of TCAP, introns included, not only the 1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TCAP gene: titin-cap. Retrieved 16 October 2026, from https://dantelabs.com/genes/tcap

Vancouver

Dante Labs. TCAP gene: titin-cap [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tcap

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