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Gene

LAMA4

laminin subunit alpha 4

Summary

Cytogenetic location
6q21
Coordinates
Chromosome 6: 112,107,931–112,254,567 (GRCh38)
Exons
39 exons across 146.6 kb
Protein
1,823 amino acids
Also known as
LAMA3
MANE Select transcript
ENST00000230538.12NM_001105206.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Dilated Cardiomyopathy

    • Enlargement and weakening of the left ventricle not explained by coronary artery or valve disease; inherited forms involve TTN, LMNA, RBM20, FLNC, BAG3, DSP, MYH7, TNNT2, DES, PLN and many other genes, and include Barth syndrome and the Emery-Dreifuss muscular dystrophies.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing a genetic cause supports earlier heart monitoring and family screening, and for genes with a high arrhythmia risk such as LMNA, FLNC and RBM20 it informs decisions about rhythm monitoring and implantable defibrillators.

How LAMA4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where LAMA4 sits. LAMA4 and 6 genes near it on chromosome 6, from 111,681,249 to 112,681,248.Chromosome 66q21p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27111.8 Mb112 Mb112.2 Mb112.4 Mb112.6 MbFYN: 111,660,332–111,873,479, reverse strandFYNCCN6: 112,043,815–112,069,686, forward strandCCN6TUBE1: 112,070,660–112,087,569, reverse strandTUBE1FAM229B: 112,087,122–112,104,326, forward strandFAM229BLAMA4: 112,107,931–112,254,567, reverse strandLAMA4: 112,236,806–112,350,094, forward strandRFPL4B: 112,347,330–112,351,294, forward strandRFPL4BDiagram of LAMA4: 39 exons on the reverse strand of chromosome 6Exon 35: 1 known disease-causing siteExon 28: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 39: 112,107,931–112,109,582, 1,652 basesExon 38: 112,114,076–112,114,195, 120 basesExon 37: 112,114,663–112,114,756, 94 basesExon 36: 112,115,863–112,115,993, 131 basesExon 35: 112,117,739–112,117,898, 160 basesExon 34: 112,119,156–112,119,311, 156 basesExon 33: 112,120,283–112,120,472, 190 basesExon 32: 112,122,014–112,122,201, 188 basesExon 31: 112,128,922–112,129,075, 154 basesExon 30: 112,129,876–112,130,040, 165 basesExon 29: 112,130,968–112,131,101, 134 basesExon 28: 112,132,753–112,132,890, 138 basesExon 27: 112,133,349–112,133,487, 139 basesExon 26: 112,134,467–112,134,609, 143 basesExon 25: 112,136,123–112,136,254, 132 basesExon 24: 112,139,120–112,139,291, 172 basesExon 23: 112,139,752–112,139,885, 134 basesExon 22: 112,140,760–112,140,922, 163 basesExon 21: 112,141,358–112,141,503, 146 basesExon 20: 112,142,119–112,142,292, 174 basesExon 19: 112,144,794–112,144,933, 140 basesExon 18: 112,148,157–112,148,336, 180 basesExon 17: 112,150,511–112,150,627, 117 basesExon 16: 112,154,851–112,154,947, 97 basesExon 15: 112,155,565–112,155,706, 142 basesExon 14: 112,158,732–112,158,880, 149 basesExon 13: 112,165,160–112,165,276, 117 basesExon 12: 112,172,611–112,172,804, 194 basesExon 11: 112,175,313–112,175,480, 168 basesExon 10: 112,178,121–112,178,232, 112 basesExon 9: 112,185,237–112,185,347, 111 basesExon 8: 112,187,450–112,187,601, 152 basesExon 7: 112,189,110–112,189,205, 96 basesExon 6: 112,191,636–112,191,850, 215 basesExon 5: 112,201,608–112,201,688, 81 basesExon 4: 112,207,021–112,207,145, 125 basesExon 3: 112,216,368–112,216,469, 102 basesExon 2: 112,253,956–112,254,291, 336 basesExon 1: 112,254,459–112,254,567, 109 bases39353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.2 kb of the gene's 146.6 kb; 5,472 of those bases code for the protein.

How a genome test reads LAMA4

3

positions in LAMA4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 146.6 kb of LAMA4, introns included, not only the 7.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LAMA4 gene: laminin subunit alpha 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/lama4

Vancouver

Dante Labs. LAMA4 gene: laminin subunit alpha 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/lama4

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