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Gene

LAMA5

laminin subunit alpha 5

Summary

Cytogenetic location
20q13.33
Coordinates
Chromosome 20: 62,309,065–62,367,312 (GRCh38)
Exons
80 exons across 58.2 kb
Protein
3,695 amino acids
MANE Select transcript
ENST00000252999.7NM_005560.6
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Nephrotic Syndrome

    • Nephrosis

      Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.

      • 1 GenCC submitter rates it definitive or strong

How LAMA5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 20, with a bracket where LAMA5 sits. LAMA5 and 18 genes near it on chromosome 20, from 61,838,189 to 62,838,188.Chromosome 2020q13.33p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3362 Mb62.2 Mb62.4 Mb62.6 Mb62.8 MbCDH4: 61,252,208–61,940,617, forward strandCDH4TAF4: 61,953,469–62,065,881, reverse strandTAF4LSM14B: 62,122,417–62,136,728, forward strandLSM14BPSMA7: 62,136,725–62,143,470, reverse strandPSMA7SS18L1: 62,143,606–62,182,514, forward strandSS18L1MTG2: 62,183,005–62,203,571, forward strandMTG2HRH3: 62,214,960–62,220,303, reverse strandHRH3OSBPL2: 62,231,922–62,296,213, forward strandOSBPL2ADRM1: 62,302,046–62,308,867, forward strandADRM1LAMA5: 62,309,065–62,367,312, reverse strandLAMA5RPS21: 62,365,598–62,388,680, forward strandRPS21CABLES2: 62,388,630–62,407,319, reverse strandCABLES2RBBP8NL: 62,410,143–62,427,548, reverse strandRBBP8NLGATA5: 62,463,481–62,476,094, reverse strandGATA5SLCO4A1: 62,642,440–62,685,785, forward strandSLCO4A1NTSR1: 62,708,427–62,762,771, forward strandNTSR1MRGBP: 62,796,452–62,801,729, forward strandMRGBPOGFR: 62,804,178–62,814,000, forward strandOGFRCOL9A3: 62,816,244–62,841,164, forward strandCOL9A3Diagram of LAMA5: 80 exons on the reverse strand of chromosome 20Exon 78: 1 known disease-causing siteExon 71: 1 known disease-causing siteExon 62: 2 known disease-causing sitesExon 59: 1 known disease-causing siteExon 53: 1 known disease-causing siteExon 52: 2 known disease-causing sitesExon 51: 1 known disease-causing siteExon 48: 1 known disease-causing siteExon 47: 1 known disease-causing siteExon 44: 1 known disease-causing siteExon 41: 1 known disease-causing siteExon 38: 1 known disease-causing siteExon 34: 3 known disease-causing sitesExon 26: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 80: 62,309,065–62,309,475, 411 basesExon 79: 62,309,716–62,309,835, 120 basesExon 78: 62,309,988–62,310,081, 94 basesExon 77: 62,310,178–62,310,311, 134 basesExon 76: 62,310,419–62,310,572, 154 basesExon 75: 62,310,665–62,310,829, 165 basesExon 74: 62,310,902–62,311,094, 193 basesExon 73: 62,311,162–62,311,307, 146 basesExon 72: 62,311,401–62,311,536, 136 basesExon 71: 62,311,614–62,311,784, 171 basesExon 70: 62,311,920–62,312,050, 131 basesExon 69: 62,312,173–62,312,316, 144 basesExon 68: 62,312,400–62,312,532, 133 basesExon 67: 62,312,632–62,312,780, 149 basesExon 66: 62,312,888–62,313,010, 123 basesExon 65: 62,313,088–62,313,250, 163 basesExon 64: 62,313,327–62,313,460, 134 basesExon 63: 62,313,649–62,313,802, 154 basesExon 62: 62,314,304–62,314,440, 137 basesExon 61: 62,314,555–62,314,725, 171 basesExon 60: 62,314,799–62,314,947, 149 basesExon 59: 62,315,028–62,315,207, 180 basesExon 58: 62,315,948–62,316,058, 111 basesExon 57: 62,316,671–62,316,773, 103 basesExon 56: 62,316,882–62,317,023, 142 basesExon 55: 62,317,345–62,317,499, 155 basesExon 54: 62,317,662–62,317,778, 117 basesExon 53: 62,318,454–62,318,650, 197 basesExon 52: 62,318,843–62,319,013, 171 basesExon 51: 62,319,684–62,319,795, 112 basesExon 50: 62,320,559–62,320,669, 111 basesExon 49: 62,320,739–62,320,890, 152 basesExon 48: 62,322,019–62,322,168, 150 basesExon 47: 62,322,269–62,322,449, 181 basesExon 46: 62,322,658–62,322,758, 101 basesExon 45: 62,323,456–62,323,670, 215 basesExon 44: 62,323,776–62,323,856, 81 basesExon 43: 62,324,080–62,324,204, 125 basesExon 42: 62,324,441–62,324,554, 114 basesExon 41: 62,325,316–62,325,546, 231 basesExon 40: 62,326,677–62,326,760, 84 basesExon 39: 62,326,865–62,326,966, 102 basesExon 38: 62,327,233–62,327,406, 174 basesExon 37: 62,327,529–62,327,669, 141 basesExon 36: 62,327,866–62,328,010, 145 basesExon 35: 62,328,241–62,328,445, 205 basesExon 34: 62,328,844–62,329,055, 212 basesExon 33: 62,329,138–62,329,253, 116 basesExon 32: 62,329,777–62,329,916, 140 basesExon 31: 62,330,488–62,330,614, 127 basesExon 30: 62,330,743–62,330,944, 202 basesExon 29: 62,331,032–62,331,129, 98 basesExon 28: 62,332,372–62,332,480, 109 basesExon 27: 62,332,557–62,332,717, 161 basesExon 26: 62,333,090–62,333,243, 154 basesExon 25: 62,333,375–62,333,481, 107 basesExon 24: 62,333,564–62,333,706, 143 basesExon 23: 62,333,901–62,334,039, 139 basesExon 22: 62,334,186–62,334,342, 157 basesExon 21: 62,334,522–62,334,621, 100 basesExon 20: 62,335,021–62,335,126, 106 basesExon 19: 62,335,217–62,335,269, 53 basesExon 18: 62,336,340–62,336,445, 106 basesExon 17: 62,336,734–62,336,786, 53 basesExon 16: 62,337,590–62,337,727, 138 basesExon 15: 62,337,804–62,337,938, 135 basesExon 14: 62,338,016–62,338,150, 135 basesExon 13: 62,338,232–62,338,369, 138 basesExon 12: 62,338,468–62,338,608, 141 basesExon 11: 62,345,818–62,345,877, 60 basesExon 10: 62,346,081–62,346,215, 135 basesExon 9: 62,346,506–62,346,596, 91 basesExon 8: 62,346,682–62,346,800, 119 basesExon 7: 62,346,913–62,347,028, 116 basesExon 6: 62,351,704–62,351,801, 98 basesExon 5: 62,351,909–62,352,079, 171 basesExon 4: 62,352,242–62,352,360, 119 basesExon 3: 62,353,134–62,353,251, 118 basesExon 2: 62,362,400–62,362,552, 153 basesExon 1: 62,366,949–62,367,312, 364 bases807060504030201015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 11.4 kb of the gene's 58.2 kb; 11,088 of those bases code for the protein.

How a genome test reads LAMA5

24

positions in LAMA5 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 58.2 kb of LAMA5, introns included, not only the 11.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LAMA5 gene: laminin subunit alpha 5. Retrieved 17 October 2026, from https://dantelabs.com/genes/lama5

Vancouver

Dante Labs. LAMA5 gene: laminin subunit alpha 5 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lama5

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