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Gene

ALB

albumin

Summary

Cytogenetic location
4q13.3
Coordinates
Chromosome 4: 73,404,287–73,421,482 (GRCh38)
Exons
15 exons across 17.2 kb
Protein
609 amino acids
MANE Select transcript
ENST00000295897.9NM_000477.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hyperthyroidism

    • Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong

  • Thyroid Cancer

    • Hyperthyroxinemia

      Abnormally elevated thyroxine level in the blood.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong
    • Hyperthyroidism

      Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong
    • Thyroid Gland Disorder

      A disease involving the thyroid gland.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong

How ALB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where ALB sits. ALB and 9 genes near it on chromosome 4, from 72,912,885 to 73,912,884.Chromosome 44q13.3p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.273 Mb73.2 Mb73.4 Mb73.6 Mb73.8 MbCOX18: 73,052,362–73,069,755, reverse strandCOX18ANKRD17: 73,073,376–73,259,169, reverse strandANKRD17ALB: 73,404,287–73,421,482, forward strandALBAFP: 73,431,138–73,456,174, forward strandAFPAFM: 73,481,659–73,504,173, forward strandAFMRASSF6: 73,571,550–73,620,631, reverse strandRASSF6CXCL8: 73,740,519–73,747,379, forward strandCXCL8CXCL6: 73,836,622–73,849,064, forward strandCXCL6PF4V1: 73,853,292–73,854,483, forward strandPF4V1CXCL1: 73,868,963–73,871,388, forward strandCXCL1Diagram of ALB: 15 exons on the forward strand of chromosome 4Exon 7: 2 known disease-causing sitesExon 1: 73,404,287–73,404,406, 120 basesExon 2: 73,405,116–73,405,173, 58 basesExon 3: 73,406,629–73,406,761, 133 basesExon 4: 73,408,594–73,408,805, 212 basesExon 5: 73,409,355–73,409,487, 133 basesExon 6: 73,410,312–73,410,409, 98 basesExon 7: 73,411,996–73,412,125, 130 basesExon 8: 73,413,420–73,413,634, 215 basesExon 9: 73,415,035–73,415,167, 133 basesExon 10: 73,416,256–73,416,353, 98 basesExon 11: 73,417,531–73,417,669, 139 basesExon 12: 73,418,088–73,418,311, 224 basesExon 13: 73,419,507–73,419,639, 133 basesExon 14: 73,420,254–73,420,321, 68 basesExon 15: 73,421,092–73,421,482, 391 bases1234567891011121314155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 17.2 kb; 1,830 of those bases code for the protein.

How a genome test reads ALB

2

positions in ALB where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 17.2 kb of ALB, introns included, not only the 2.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ALB gene: albumin. Retrieved 17 October 2026, from https://dantelabs.com/genes/alb

Vancouver

Dante Labs. ALB gene: albumin [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/alb

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