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Gene

ARHGDIA

Rho GDP dissociation inhibitor alpha

Summary

Cytogenetic location
17q25.3
Coordinates
Chromosome 17: 81,867,721–81,871,337 (GRCh38)
Exons
6 exons across 3.6 kb
Protein
204 amino acids
Also known as
RHOGDI
Previous symbols
GDIA1
MANE Select transcript
ENST00000269321.12NM_004309.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Nephrotic Syndrome

    • Nephrosis

      Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong

How ARHGDIA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 17, with a bracket where ARHGDIA sits. ARHGDIA and 43 genes near it on chromosome 17, from 81,369,529 to 82,369,528.Chromosome 1717q25.3p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.381.4 Mb81.6 Mb81.8 Mb82 Mb82.2 MbBAHCC1: 81,395,450–81,466,331, forward strandBAHCC1ACTG1: 81,509,413–81,523,847, reverse strandACTG1FSCN2: 81,528,372–81,542,415, forward strandFSCN2FAAP100: 81,539,885–81,553,961, reverse strandFAAP100NPLOC4: 81,556,887–81,648,465, reverse strandNPLOC4TSPAN10: 81,637,171–81,648,754, forward strandPDE6G: 81,650,459–81,663,112, reverse strandOXLD1: 81,665,033–81,666,635, reverse strandCCDC137: 81,666,698–81,673,904, forward strandARL16: 81,681,160–81,683,797, reverse strandHGS: 81,683,326–81,703,138, forward strandHGSMRPL12: 81,703,357–81,711,112, forward strandMRPL12: 81,703,371–81,720,539, forward strandSLC25A10: 81,711,951–81,721,969, forward strandSLC25A10GCGR: 81,803,105–81,814,023, forward strandGCGRMCRIP1: 81,821,790–81,833,302, reverse strandMCRIP1PPP1R27: 81,833,488–81,835,056, reverse strandP4HB: 81,843,158–81,860,856, reverse strandP4HBARHGDIA: 81,867,721–81,871,337, reverse strandARHGDIAALYREF: 81,887,830–81,891,835, reverse strandALYREFANAPC11: 81,890,669–81,900,991, forward strandANAPC11NPB: 81,900,745–81,902,905, forward strandNPBPCYT2: 81,900,958–81,911,507, reverse strandSIRT7: 81,911,939–81,921,323, reverse strandMAFG: 81,918,270–81,927,769, reverse strandPYCR1: 81,932,378–81,942,412, reverse strandMYADML2: 81,939,645–81,947,233, reverse strandNOTUM: 81,952,507–81,963,328, reverse strandNOTUMASPSCR1: 81,976,807–82,018,698, forward strandASPSCR1CENPX: 82,018,590–82,024,107, reverse strandCENPXLRRC45: 82,023,269–82,031,153, forward strandLRRC45RAC3: 82,031,192–82,034,218, forward strandRAC3DCXR: 82,035,136–82,037,777, reverse strandRFNG: 82,047,902–82,051,871, reverse strandGPS1: 82,050,691–82,058,063, forward strandDUS1L: 82,057,506–82,066,206, reverse strandFASN: 82,076,900–82,098,294, reverse strandFASNCCDC57: 82,101,458–82,212,885, reverse strandCCDC57SLC16A3: 82,217,878–82,261,176, forward strandSLC16A3CSNK1D: 82,239,023–82,273,730, reverse strandCSNK1DCD7: 82,313,564–82,317,625, reverse strandCD7SECTM1: 82,321,024–82,335,518, reverse strandSECTM1TEX19: 82,359,246–82,363,775, forward strandTEX19UTS2R: 82,368,266–82,377,709, forward strandUTS2RDiagram of ARHGDIA: 6 exons on the reverse strand of chromosome 17Exon 6: 1 known disease-causing siteExon 6: 81,867,721–81,869,075, 1,355 basesExon 5: 81,869,173–81,869,236, 64 basesExon 4: 81,869,330–81,869,406, 77 basesExon 3: 81,869,542–81,869,625, 84 basesExon 2: 81,869,741–81,869,957, 217 basesExon 1: 81,871,298–81,871,337, 40 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.8 kb of the gene's 3.6 kb; 615 of those bases code for the protein.

How a genome test reads ARHGDIA

1

position in ARHGDIA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.6 kb of ARHGDIA, introns included, not only the 1.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ARHGDIA gene: Rho GDP dissociation inhibitor alpha. Retrieved 17 October 2026, from https://dantelabs.com/genes/arhgdia

Vancouver

Dante Labs. ARHGDIA gene: Rho GDP dissociation inhibitor alpha [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/arhgdia

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