Gene
ZEB1
zinc finger E-box binding homeobox 1
- HGNC 11642(opens in a new tab)
- Ensembl gene ENSG00000148516(opens in a new tab)
- NCBI Gene 6935(opens in a new tab)
Summary
- Cytogenetic location
- 10p11.22
- Coordinates
- Chromosome 10: 31,319,216–31,529,804 (GRCh38)
- Exons
- 9 exons across 210.6 kb
- Protein
- 1,125 amino acids
- Also known as
- BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a, FECD6
- Previous symbols
- TCF8, PPCD3
- MANE Select transcript
- ENST00000424869.6NM_001174096.2
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read ZEB1, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome TestCurated report relevant to this gene
Hereditary Corneal Dystrophies
- Corneal Dystrophy
A group of inherited conditions affecting one or more layers of the cornea, including Fuchs endothelial dystrophy (often linked to a TCF4 repeat expansion), TGFBI-related granular and lattice dystrophies, and rarer types caused by genes such as SLC4A11, COL8A2, ZEB1 and CHST6.
- 3 GenCC submitters rate it definitive or strong
What knowing changes
Carriers of TGFBI variants are generally advised to avoid laser refractive surgery (LASIK or PRK), which can make deposits worse; corneal transplant can restore vision in advanced disease.
How ZEB1 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 5.9 kb of the gene's 210.6 kb; 3,378 of those bases code for the protein.
How a genome test reads ZEB1
15
positions in ZEB1 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 210.6 kb of ZEB1, introns included, not only the 5.9 kb of exons.
Traits linked to ZEB1
The Human Phenotype Ontology lists these as features of the rare conditions ZEB1 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the eye
- Bulging cornea
- Corneal dystrophy
- Decreased clarity of vision
- Displaced pupil
- Abnormal corneal endothelium morphology
- Abnormal Descemet membrane morphology
- Corneal opacity
- Reduced number of corneal endothelial cells
Show 19 more traits
- Difficulties with night vision
- Eye movement-induced pain
- Visual loss
- Anterior synechiae of the anterior chamber
- Astigmatism
- Increased corneal curvature
- Lazy eye
- Uveal ectropion
- Very low visual acuity
- Abnormality of tear production
- Blurred vision
- Chorioretinal atrophy
- Extreme sensitivity of the eyes to light
- Eye pain
- Glaucoma
- High eye pressure
- Inward turning cross eyed
- Corneal guttata
- Corneal inflammation
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). ZEB1 gene: zinc finger E-box binding homeobox 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/zeb1
Dante Labs. ZEB1 gene: zinc finger E-box binding homeobox 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/zeb1
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks