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Gene

NRAP

nebulin related anchoring protein

Summary

Cytogenetic location
10q25.3
Coordinates
Chromosome 10: 113,588,714–113,664,041 (GRCh38)
Exons
42 exons across 75.3 kb
Protein
1,730 amino acids
MANE Select transcript
ENST00000359988.4NM_198060.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Dilated Cardiomyopathy

    • Enlargement and weakening of the left ventricle not explained by coronary artery or valve disease; inherited forms involve TTN, LMNA, RBM20, FLNC, BAG3, DSP, MYH7, TNNT2, DES, PLN and many other genes, and include Barth syndrome and the Emery-Dreifuss muscular dystrophies.

      • ClinGen rates the link strong
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing a genetic cause supports earlier heart monitoring and family screening, and for genes with a high arrhythmia risk such as LMNA, FLNC and RBM20 it informs decisions about rhythm monitoring and implantable defibrillators.

How NRAP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 10, with a bracket where NRAP sits. NRAP and 8 genes near it on chromosome 10, from 113,126,378 to 114,126,377.Chromosome 1010q25.3p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.3113.2 Mb113.4 Mb113.6 Mb113.8 Mb114 MbTCF7L2: 112,950,015–113,167,678, forward strandTCF7L2HABP2: 113,550,837–113,592,878, forward strandHABP2NRAP: 113,588,714–113,664,041, reverse strandNRAPCASP7: 113,679,158–113,731,668, forward strandCASP7PLEKHS1: 113,751,262–113,783,429, forward strandPLEKHS1DCLRE1A: 113,834,725–113,854,417, reverse strandDCLRE1ANHLRC2: 113,854,475–113,917,194, forward strandNHLRC2ADRB1: 114,043,866–114,046,904, forward strandADRB1CCDC186: 114,120,862–114,174,237, reverse strandCCDC186Diagram of NRAP: 42 exons on the reverse strand of chromosome 10Exon 42: 113,588,714–113,589,079, 366 basesExon 41: 113,589,666–113,589,797, 132 basesExon 40: 113,590,578–113,590,889, 312 basesExon 39: 113,592,194–113,592,301, 108 basesExon 38: 113,595,623–113,595,727, 105 basesExon 37: 113,597,086–113,597,184, 99 basesExon 36: 113,597,969–113,598,073, 105 basesExon 35: 113,604,609–113,604,920, 312 basesExon 34: 113,605,762–113,605,869, 108 basesExon 33: 113,606,178–113,606,282, 105 basesExon 32: 113,608,414–113,608,512, 99 basesExon 31: 113,610,459–113,610,563, 105 basesExon 30: 113,612,234–113,612,431, 198 basesExon 29: 113,614,183–113,614,296, 114 basesExon 28: 113,614,839–113,614,946, 108 basesExon 27: 113,615,712–113,615,816, 105 basesExon 26: 113,617,455–113,617,553, 99 basesExon 25: 113,620,604–113,620,708, 105 basesExon 24: 113,621,869–113,622,180, 312 basesExon 23: 113,623,529–113,623,636, 108 basesExon 22: 113,624,826–113,624,930, 105 basesExon 21: 113,626,047–113,626,145, 99 basesExon 20: 113,628,917–113,629,021, 105 basesExon 19: 113,629,588–113,629,785, 198 basesExon 18: 113,631,509–113,631,610, 102 basesExon 17: 113,631,857–113,631,964, 108 basesExon 16: 113,633,084–113,633,188, 105 basesExon 15: 113,634,112–113,634,210, 99 basesExon 14: 113,640,227–113,640,331, 105 basesExon 13: 113,641,365–113,641,472, 108 basesExon 12: 113,642,934–113,643,038, 105 basesExon 11: 113,645,825–113,645,941, 117 basesExon 10: 113,646,923–113,647,027, 105 basesExon 9: 113,650,037–113,650,141, 105 basesExon 8: 113,650,438–113,650,545, 108 basesExon 7: 113,651,803–113,651,907, 105 basesExon 6: 113,652,935–113,653,039, 105 basesExon 5: 113,654,021–113,654,125, 105 basesExon 4: 113,657,470–113,657,574, 105 basesExon 3: 113,662,679–113,662,766, 88 basesExon 2: 113,663,352–113,663,446, 95 basesExon 1: 113,663,811–113,664,041, 231 bases4240353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.6 kb of the gene's 75.3 kb; 5,193 of those bases code for the protein.

Genes linked to the same conditions

Traits linked to NRAP

The Human Phenotype Ontology lists these as features of the rare conditions NRAP can cause. Each trait's page lists the other genes linked to it.

Abnormality of the cardiovascular system

Show 19 more traits

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NRAP gene: nebulin related anchoring protein. Retrieved 17 October 2026, from https://dantelabs.com/genes/nrap

Vancouver

Dante Labs. NRAP gene: nebulin related anchoring protein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nrap

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