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Gene

ANLN

anillin, actin binding protein

Summary

Cytogenetic location
7p14.2
Coordinates
Chromosome 7: 36,389,862–36,453,791 (GRCh38)
Exons
24 exons across 63.9 kb
Protein
1,124 amino acids
Also known as
ANILLIN, Scraps, scra
MANE Select transcript
ENST00000265748.7NM_018685.5
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

  • Focal Segmental Glomerulosclerosis

    • A renal disorder characterized by sclerotic lesions in the glomeruli. Causes include drugs, viruses, and malignancies (lymphomas), or it may be idiopathic. It presents with asymptomatic proteinuria or nephritic syndrome and it may lead to renal failure.

      • 1 GenCC submitter rates it definitive or strong

  • Glomerulosclerosis

    • A hardening of the kidney glomerulus caused by scarring of the blood vessels.

      • 1 GenCC submitter rates it definitive or strong

How ANLN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where ANLN sits. ANLN and 4 genes near it on chromosome 7, from 35,921,827 to 36,921,826.Chromosome 77p14.2p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.336 Mb36.2 Mb36.4 Mb36.6 Mb36.8 MbEEPD1: 36,153,075–36,301,557, forward strandEEPD1MATCAP2: 36,323,935–36,390,125, reverse strandMATCAP2ANLN: 36,389,862–36,453,791, forward strandANLNAOAH: 36,509,308–36,724,549, reverse strandAOAHELMO1: 36,852,906–37,449,435, reverse strandELMO1Diagram of ANLN: 24 exons on the forward strand of chromosome 7Exon 7: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 1: 36,389,862–36,390,044, 183 basesExon 2: 36,396,266–36,396,419, 154 basesExon 3: 36,399,079–36,399,393, 315 basesExon 4: 36,406,181–36,406,566, 386 basesExon 5: 36,407,734–36,407,956, 223 basesExon 6: 36,410,514–36,410,704, 191 basesExon 7: 36,411,059–36,411,166, 108 basesExon 8: 36,415,758–36,415,884, 127 basesExon 9: 36,417,080–36,417,190, 111 basesExon 10: 36,419,244–36,419,479, 236 basesExon 11: 36,420,169–36,420,314, 146 basesExon 12: 36,420,597–36,420,744, 148 basesExon 13: 36,421,857–36,421,992, 136 basesExon 14: 36,422,633–36,422,809, 177 basesExon 15: 36,423,817–36,423,943, 127 basesExon 16: 36,424,545–36,424,593, 49 basesExon 17: 36,424,686–36,424,742, 57 basesExon 18: 36,425,702–36,425,740, 39 basesExon 19: 36,426,015–36,426,036, 22 basesExon 20: 36,426,916–36,427,028, 113 basesExon 21: 36,439,204–36,439,290, 87 basesExon 22: 36,443,755–36,443,862, 108 basesExon 23: 36,449,665–36,449,837, 173 basesExon 24: 36,452,477–36,453,791, 1,315 bases15101520245′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.7 kb of the gene's 63.9 kb; 3,375 of those bases code for the protein.

Sequencing ANLN

2

positions in ANLN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 63.9 kb of ANLN, introns included, not only the 4.7 kb of exons.

Genes linked to the same conditions

Traits linked to ANLN

The Human Phenotype Ontology lists these as features of the rare conditions ANLN can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). ANLN gene: anillin, actin binding protein. Retrieved 17 October 2026, from https://dantelabs.com/genes/anln

Vancouver

Dante Labs. ANLN gene: anillin, actin binding protein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/anln

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