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Gene

STX11

syntaxin 11

Summary

Cytogenetic location
6q24.2
Coordinates
Chromosome 6: 144,150,517–144,191,939 (GRCh38)
Exons
2 exons across 41.4 kb
Protein
287 amino acids
Inheritance
Autosomal recessive
MANE Select transcript
ENST00000367568.5NM_003764.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Familial Hemophagocytic Lymphohistiocytosis

    • Familial hemophagocytic lymphohistiocytosis type 4 (STX11)Autosomal recessive

      Caused by changes in the STX11 gene, which is involved in the release of killing granules from immune cells.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Early recognition allows prompt treatment and planning for a stem cell transplant, which is the only cure.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How STX11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where STX11 sits. STX11 and 8 genes near it on chromosome 6, from 143,671,228 to 144,671,227.Chromosome 66q24.2p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27143.8 Mb144 Mb144.2 Mb144.4 Mb144.6 MbPHACTR2: 143,536,582–143,831,185, forward strandPHACTR2: 143,807,092–143,844,617, forward strandLTV1: 143,843,302–143,864,329, forward strandLTV1: 143,857,318–143,938,471, forward strandZC2HC1B: 143,864,436–143,940,363, forward strandZC2HC1BPLAGL1: 143,940,300–144,064,714, reverse strandPLAGL1SF3B5: 144,094,884–144,095,573, reverse strandSF3B5STX11: 144,150,517–144,191,939, forward strandSTX11UTRN: 144,284,852–144,853,034, forward strandUTRNDiagram of STX11: 2 exons on the forward strand of chromosome 6Exon 2: 25 known disease-causing sitesExon 1: 144,150,517–144,150,703, 187 basesExon 2: 144,186,623–144,191,939, 5,317 bases125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.5 kb of the gene's 41.4 kb; 864 of those bases code for the protein.

How a genome test reads STX11

25

positions in STX11 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 41.4 kb of STX11, introns included, not only the 5.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). STX11 gene: syntaxin 11. Retrieved 16 October 2026, from https://dantelabs.com/genes/stx11

Vancouver

Dante Labs. STX11 gene: syntaxin 11 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/stx11

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