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Gene

TXNRD2

thioredoxin reductase 2

Summary

Cytogenetic location
22q11.21
Coordinates
Chromosome 22: 19,875,522–19,941,818 (GRCh38)
Exons
18 exons across 66.3 kb
Protein
524 amino acids
Inheritance
Autosomal recessive
Also known as
TR, TRXR2, TR3, SELZ, TXNR2
MANE Select transcript
ENST00000400521.7NM_006440.5
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How TXNRD2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 22, with a bracket where TXNRD2 sits. TXNRD2 and 23 genes near it on chromosome 22, from 19,408,670 to 20,408,669.Chromosome 2222q11.21p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3319.6 Mb19.8 Mb20 Mb20.2 Mb20.4 MbHIRA: 19,330,185–19,447,450, reverse strandHIRAC22orf39: 19,351,368–19,447,714, reverse strandC22orf39MRPL40: 19,431,837–19,436,078, forward strandMRPL40UFD1: 19,449,899–19,479,695, reverse strandUFD1CDC45: 19,479,457–19,520,612, forward strandCDC45CLDN5: 19,517,452–19,527,545, reverse strandCLDN5SEPTIN5: 19,714,117–19,724,781, forward strandSEPTIN5: 19,717,220–19,724,772, forward strandGP1BB: 19,723,539–19,724,776, forward strandGP1BBTBX1: 19,756,703–19,783,593, forward strandTBX1GNB1L: 19,781,243–19,854,947, reverse strandGNB1LRTL10: 19,846,138–19,854,939, reverse strandRTL10TXNRD2: 19,875,522–19,941,818, reverse strandTXNRD2COMT: 19,941,371–19,969,975, forward strandCOMTARVCF: 19,969,866–20,016,862, reverse strandARVCFTANGO2: 20,016,615–20,067,962, forward strandTANGO2DGCR8: 20,080,025–20,111,877, forward strandDGCR8TRMT2A: 20,111,866–20,117,392, reverse strandTRMT2ARANBP1: 20,115,877–20,128,037, forward strandRANBP1ZDHHC8: 20,129,456–20,148,007, forward strandZDHHC8CCDC188: 20,146,381–20,151,059, reverse strandRTN4R: 20,241,415–20,283,246, reverse strandRTN4RDGCR6L: 20,312,140–20,320,085, reverse strandDGCR6LZNF74: 20,394,115–20,409,406, forward strandZNF74Diagram of TXNRD2: 18 exons on the reverse strand of chromosome 22Exon 15: 1 known disease-causing siteExon 18: 19,875,522–19,875,807, 286 basesExon 17: 19,877,040–19,877,234, 195 basesExon 16: 19,878,090–19,878,187, 98 basesExon 15: 19,878,366–19,878,437, 72 basesExon 14: 19,880,179–19,880,271, 93 basesExon 13: 19,880,622–19,880,717, 96 basesExon 12: 19,883,325–19,883,461, 137 basesExon 11: 19,895,407–19,895,581, 175 basesExon 10: 19,898,039–19,898,130, 92 basesExon 9: 19,899,049–19,899,068, 20 basesExon 8: 19,911,377–19,911,447, 71 basesExon 7: 19,915,214–19,915,276, 63 basesExon 6: 19,915,765–19,915,843, 79 basesExon 5: 19,918,143–19,918,217, 75 basesExon 4: 19,918,860–19,919,004, 145 basesExon 3: 19,919,543–19,919,599, 57 basesExon 2: 19,931,030–19,931,098, 69 basesExon 1: 19,941,701–19,941,818, 118 bases1816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 66.3 kb; 1,575 of those bases code for the protein.

How a genome test reads TXNRD2

1

position in TXNRD2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 66.3 kb of TXNRD2, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TXNRD2 gene: thioredoxin reductase 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/txnrd2

Vancouver

Dante Labs. TXNRD2 gene: thioredoxin reductase 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/txnrd2

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