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Gene

WT1

WT1 transcription factor

Summary

Cytogenetic location
11p13
Coordinates
Chromosome 11: 32,387,775–32,435,539 (GRCh38)
Exons
10 exons across 47.8 kb
Protein
522 amino acids
Also known as
WAGR, WIT-2, AWT1, NPHS4, WT-1
Previous symbols
GUD
MANE Select transcript
ENST00000452863.10NM_024426.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • 46,XY Differences of Sex Development and Gonadal Dysgenesis

    • 46,XY differences of sex development

      Conditions in people with XY chromosomes in which gonadal or genital development is atypical, caused by variants in genes such as SRD5A2, HSD17B3, NR5A1, MAP3K1, DHH, WT1, CYP11A1 and LHCGR.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Diagnosis informs hormone treatment, fertility counselling and, where dysgenetic gonads carry Y material, assessment of gonadal tumour risk.

  • Hereditary Wilms Tumour

    • Inherited susceptibility to Wilms tumour (nephroblastoma), including WT1- and REST-related forms.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      • On the ACMG secondary findings list
      What knowing changes

      Regular kidney ultrasound in early childhood allows tumours to be found early; WT1 carriers may also need kidney-function and gonadal checks.

How WT1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
  • Variants with a page
Chromosome 11, with a bracket where WT1 sits. WT1 and 6 genes near it on chromosome 11, from 31,911,657 to 32,911,656.Chromosome 1111p13p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2532 Mb32.2 Mb32.4 Mb32.6 Mb32.8 Mb: 31,812,391–32,104,665, forward strandRCN1: 32,090,968–32,107,639, forward strandRCN1WT1: 32,387,775–32,435,539, reverse strandWT1EIF3M: 32,583,742–32,606,264, forward strandEIF3MCCDC73: 32,602,246–32,795,367, reverse strandCCDC73PRRG4: 32,829,675–32,858,120, forward strandPRRG4QSER1: 32,892,811–32,993,316, forward strandQSER1Diagram of WT1: 10 exons on the reverse strand of chromosome 11Exon 10: 5 known disease-causing sitesExon 9: 19 known disease-causing sitesExon 8: 12 known disease-causing sitesExon 7: 14 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 3: 5 known disease-causing sitesExon 2: 6 known disease-causing sitesExon 1: 29 known disease-causing sitesExon 10: 32,387,775–32,389,179, 1,405 bases. 1 variant with a page in exon 10. List themExon 9: 32,391,972–32,392,064, 93 bases. 5 variants with a page in exon 9. List themExon 8: 32,392,666–32,392,755, 90 bases. 4 variants with a page in exon 8. List themExon 7: 32,396,257–32,396,407, 151 bases. 2 variants with a page in exon 7. List themExon 6: 32,399,948–32,400,044, 97 basesExon 5: 32,416,490–32,416,540, 51 basesExon 4: 32,417,577–32,417,654, 78 basesExon 3: 32,427,956–32,428,058, 103 bases. 1 variant with a page in exon 3. List themExon 2: 32,428,497–32,428,619, 123 basesExon 1: 32,434,700–32,435,539, 840 bases. 2 variants with a page in exon 1. List them10864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3 kb of the gene's 47.8 kb; 1,569 of those bases code for the protein.

How a genome test reads WT1

112

positions in WT1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 47.8 kb of WT1, introns included, not only the 3 kb of exons.

Variants with a page (19)

The WT1 variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.

VariantHGVS c.Exon or intronPosition (GRCh38)ClinVar classificationReview status
c.965+1G>AIntron 432,417,576Likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
c.1447+4C>T1432+4C>TIntron 932,391,968Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
c.1447+5G>A1432+5G>AIntron 932,391,967Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
c.1448-1G>AIntron 932,389,180Likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
G152Afs*11c.455delExon 132,434,905Pathogenic/likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
H446Qc.1338C>AExon 832,392,682Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
H450Yc.1348C>TExon 832,392,672Pathogenic/likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
P137Rfs*26c.410delExon 132,434,950Pathogenic/likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
Q462Xc.1384C>TExon 932,392,035Likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
R374Xc.1120C>TExon 732,396,401Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts

See all 19 WT1 variants →

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). WT1 gene: WT1 transcription factor. Retrieved 16 October 2026, from https://dantelabs.com/genes/wt1

Vancouver

Dante Labs. WT1 gene: WT1 transcription factor [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/wt1

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