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Gene

ALG8

ALG8 alpha-1,3-glucosyltransferase

Summary

Cytogenetic location
11q14.1
Coordinates
Chromosome 11: 78,100,946–78,139,626 (GRCh38)
Exons
13 exons across 38.7 kb
Protein
526 amino acids
Inheritance
Autosomal dominant
Also known as
MGC2840
MANE Select transcript
ENST00000299626.10NM_024079.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Polycystic Kidney Disease

    • A usually autosomal dominant and less frequently autosomal recessive genetic disorder characterized by the presence of numerous cysts in the kidneys leading to end-stage renal failure. The autosomal dominant trait is associated with abnormalities on the short arm of chromosome 16. Symptoms in patients with the autosomal dominant trait usually appear at middle age and include abdominal pain, hematuria, and high blood pressure. Patients may develop brain aneurysms and liver cysts. Patients with the autosomal recessive trait present with progressive renal failure early in life and symptoms resulting from hepatic fibrosis. The autosomal recessive trait is associated with abnormalities of chromosome 6. Polycystic kidney disease may also result as a side effect in patients on renal dialysis.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Tolvaptan (Jynarque, FDA 2018) for rapidly progressive ADPKD; blood pressure control (target <110/75); pain management; cyst infection treatment; brain MRA screening for intracranial aneurysms; kidney transplantation for ESRD

  • Polycystic Liver Disease (1 and 2)

    • Polycystic Liver Disease 3Autosomal dominant

      A dominantly inherited condition caused by ALG8 variants, with multiple liver cysts and sometimes kidney cysts.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing can prompt liver and kidney imaging when symptoms arise.

Broader groupings

  • Congenital Disorders of Glycosylation

    • Congenital Disorders of Glycosylation (CDG)

      One of 98 genes linked to it

      A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How ALG8 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where ALG8 sits. ALG8 and 13 genes near it on chromosome 11, from 77,620,286 to 78,620,285.Chromosome 1111q14.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2577.8 Mb78 Mb78.2 Mb78.4 Mb78.6 MbCLNS1A: 77,514,936–77,637,813, reverse strandCLNS1AAQP11: 77,589,391–77,635,772, forward strandAQP11RSF1: 77,660,009–77,821,020, reverse strandRSF1AAMDC: 77,821,100–77,918,693, forward strandAAMDCINTS4: 77,874,418–77,994,874, reverse strandINTS4KCTD14: 78,015,715–78,046,191, reverse strandKCTD14NDUFC2-KCTD14: 78,016,971–78,079,865, reverse strandNDUFC2-KCTD14THRSP: 78,063,660–78,068,351, forward strandTHRSPNDUFC2: 78,068,297–78,081,871, reverse strandNDUFC2ALG8: 78,100,946–78,139,626, reverse strandALG8KCTD21: 78,171,233–78,188,644, reverse strandKCTD21USP35: 78,188,797–78,215,232, forward strandUSP35GAB2: 78,215,293–78,418,348, reverse strandGAB2NARS2: 78,435,539–78,575,194, reverse strandNARS2Diagram of ALG8: 13 exons on the reverse strand of chromosome 11Exon 13: 2 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 10: 6 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 8: 6 known disease-causing sitesExon 7: 5 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 3: 4 known disease-causing sitesExon 2: 6 known disease-causing sitesExon 13: 78,100,946–78,101,195, 250 basesExon 12: 78,103,980–78,104,052, 73 basesExon 11: 78,104,356–78,104,453, 98 basesExon 10: 78,106,807–78,106,946, 140 basesExon 9: 78,109,442–78,109,581, 140 basesExon 8: 78,112,650–78,112,770, 121 basesExon 7: 78,113,886–78,113,989, 104 basesExon 6: 78,114,266–78,114,392, 127 basesExon 5: 78,119,182–78,119,249, 68 basesExon 4: 78,121,065–78,121,174, 110 basesExon 3: 78,124,021–78,124,214, 194 basesExon 2: 78,127,358–78,127,436, 79 basesExon 1: 78,139,494–78,139,626, 133 bases131210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 38.7 kb; 1,581 of those bases code for the protein.

How a genome test reads ALG8

50

positions in ALG8 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 38.7 kb of ALG8, introns included, not only the 1.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ALG8 gene: ALG8 alpha-1,3-glucosyltransferase. Retrieved 17 October 2026, from https://dantelabs.com/genes/alg8

Vancouver

Dante Labs. ALG8 gene: ALG8 alpha-1,3-glucosyltransferase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/alg8

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